公开(公告)号：US20100240995A1

公开(公告)日：2010-09-23

申请号：US12726037

申请日：2010-03-17

Applicant: Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Saleh SHEIKH ,  Kevin Tran ,  Brian Athos ,  Mark Kreis

Inventor： Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Saleh SHEIKH ,  Kevin Tran ,  Brian Athos ,  Mark Kreis

IPC: A61B18/14 ,  A61B8/00

CPC classification number: A61B18/1492 ,  A61B8/12 ,  A61B18/1477 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2090/3782

Abstract: Systems and methods for treating tumors on or within internal organs of mammals that have been imaged with endoscopic ultrasound are described. The system uses an expandable bipolar electrode assembly that can be imaged by ultrasound and can penetrate, e.g., the stomach, intestine or bowel wall, etc. and be positioned in or around the tumor on an internal organ while being guided by an operator who visualizes its position with ultrasound imaging. It utilizes an electrode assembly that extends down an internal cavity in the endoscope to allow the operator to spread the electrodes for pulse delivery of a nanosecond pulsed electric field (nsPEF) to the tumor.

Abstract translation: 描述了已经用内窥镜超声成像的用于治疗哺乳动物的内部器官上或内部的肿瘤的系统和方法。 该系统使用可通过超声波成像的可扩张双极电极组件，并且可以穿透例如胃，肠或肠壁等，并且定位在内部器官的肿瘤内或周围，同时由可视化的操作者引导 其位置与超声成像。 它利用沿内窥镜内腔延伸的电极组件，以允许操作者将电极扩展到纳秒脉冲电场（nsPEF）的脉冲输送到肿瘤。

公开(公告)号：US08694088B2

公开(公告)日：2014-04-08

申请号：US12117598

申请日：2008-05-08

Applicant: Richard Nuccitelli ,  Pamela Nuccitelli ,  Shr-Kai Liau ,  Uwe F. Pliquett ,  Changyi Li ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

Inventor： Richard Nuccitelli ,  Pamela Nuccitelli ,  Shr-Kai Liau ,  Uwe F. Pliquett ,  Changyi Li ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

IPC: A61B5/00

CPC classification number: A61B5/444 ,  A61B5/0051 ,  A61B5/04 ,  A61B5/442 ,  A61B5/6844 ,  A61B2560/04 ,  A61B2562/0214

Abstract: The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

Abstract translation: 本发明提供了用于测量哺乳动物皮肤和其它上皮结构中的电场的手持式无创诊断装置。 该装置包括接触皮肤的外壳，提供稳定性并允许装置随着皮肤的轻微移动而移动。 嵌入在外壳内部的探头是用作传感器的探针，用于通过外壳底面的孔来测量皮肤中的电场。 通过在探头振动时应用一系列已知的电压，可以测量皮肤的局部表面电位，并可以从表面电位测量的空间分布计算横向电场。 主动反馈用于保持探头与皮肤表面之间的恒定距离。

公开(公告)号：US20100318082A1

公开(公告)日：2010-12-16

申请号：US12722441

申请日：2010-03-11

Applicant: Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Saleh SHEIKH ,  Kevin TRAN ,  Brian Athos ,  Mark KREIS

Inventor： Richard Lee NUCCITELLI ,  Pamela NUCCITELLI ,  Saleh SHEIKH ,  Kevin TRAN ,  Brian Athos ,  Mark KREIS

IPC: A61B18/04

CPC classification number: A61B18/14 ,  A61B18/1206 ,  A61B18/1477 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00577 ,  A61B2018/00726 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1467

Abstract: Nanosecond pulsed electric field (nsPEF) parameters for destroying tumors with a single treatment are described. A nsPEF generator may be used with an electrode assembly to apply the pulses to one or more tumors where the parameters for the nsPEF are optimized for treating such tumors.

Abstract translation: 描述了用单次处理破坏肿瘤的纳秒脉冲电场（nsPEF）参数。 nsPEF发生器可以与电极组件一起使用以将脉冲施加到一个或多个肿瘤，其中nsPEF的参数被优化用于治疗这样的肿瘤。

公开(公告)号：US20090281411A1

公开(公告)日：2009-11-12

申请号：US12117598

申请日：2008-05-08

Applicant: Richard Nuccitelli ,  Pamela Nuccitelli ,  Shr-Kai Liau ,  Uwe F. Pliquett ,  Changyi Li ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

Inventor： Richard Nuccitelli ,  Pamela Nuccitelli ,  Shr-Kai Liau ,  Uwe F. Pliquett ,  Changyi Li ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

IPC: A61B5/05

CPC classification number: A61B5/444 ,  A61B5/0051 ,  A61B5/04 ,  A61B5/442 ,  A61B5/6844 ,  A61B2560/04 ,  A61B2562/0214

Abstract: The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

Abstract translation: 本发明提供了用于测量哺乳动物皮肤和其它上皮结构中的电场的手持式无创诊断装置。 该装置包括接触皮肤的外壳，提供稳定性并允许装置随着皮肤的轻微移动而移动。 嵌入在外壳内部的探头是用作传感器的探针，用于通过外壳底面的孔来测量皮肤中的电场。 通过在探头振动时应用一系列已知的电压，可以测量皮肤的局部表面电位，并可以从表面电位测量的空间分布计算横向电场。 主动反馈用于保持探头与皮肤表面之间的恒定距离。

公开(公告)号：US08597187B2

公开(公告)日：2013-12-03

申请号：US12484971

申请日：2009-06-15

Applicant: Richard Lee Nuccitelli ,  Pamela Nuccitelli ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

Inventor： Richard Lee Nuccitelli ,  Pamela Nuccitelli ,  Suman Narsing ,  Brian Athos ,  Saleh Sheikh

IPC: A61B5/103

CPC classification number: A61B5/442 ,  A61B5/0051 ,  A61B5/053 ,  A61B5/063 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6886

Abstract: The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

Abstract translation: 本发明提供了用于测量哺乳动物皮肤和其它上皮结构中的电场的手持式无创诊断装置。 该装置包括接触皮肤的外壳，提供稳定性并允许装置随着皮肤的轻微移动而移动。 嵌入在外壳内部的探头是用作传感器的探针，用于通过外壳底面的孔来测量皮肤中的电场。 通过在探头振动时应用一系列已知的电压，可以测量皮肤的局部表面电位，并可以从表面电位测量的空间分布计算横向电场。 主动反馈用于保持探头与皮肤表面之间的恒定距离。