公开(公告)号：US07368479B2

公开(公告)日：2008-05-06

申请号：US10517977

申请日：2003-06-18

Applicant: Martin Eberle ,  Daniel Stierli ,  Urs Müller

Inventor： Martin Eberle ,  Daniel Stierli ,  Urs Müller

IPC: A61K31/275 ,  C07C255/00

CPC classification number: C07D207/27 ,  A01N41/06 ,  A01N43/36 ,  A01N43/40 ,  A01N43/50 ,  A01N43/56 ,  A01N43/653 ,  A01N43/78 ,  C07C311/13 ,  C07C317/20 ,  C07C323/20 ,  C07D213/30 ,  C07D213/643 ,  C07D213/85 ,  C07D231/12 ,  C07D233/54 ,  C07D239/26 ,  C07D239/42 ,  C07D239/60 ,  C07D241/42 ,  C07D249/08 ,  C07D271/10 ,  C07D277/24 ,  C07D277/34 ,  C07D277/36 ,  C07D277/42 ,  C07D285/08 ,  C07D285/12 ,  C07D295/205 ,  C07D295/215

Abstract: The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1, and R2 stand independently of each other for hydrogen, optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R3 designates hydrogen, C3-C5alkenyl, C3-C5alkynyl or optionally substituted C1,-C5alkyl; R4 is optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R7, and R8 are independently of each other hydrogen or optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; W designates a bridge selected from —O— —S(O)m— or —NR3—; X designates a direct bond or a bridge selected from —O—, —S(O)m— or —NR3—; a and b independently of each other stand for a number 1, 2 or 3; and c and m independently of each other stand for a number zero, 1 or 2. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

公开(公告)号：US06326349B1

公开(公告)日：2001-12-04

申请号：US09388020

申请日：1999-09-01

Applicant: Daniel Helmlinger ,  Georg Fráter ,  Urs Müller

Inventor： Daniel Helmlinger ,  Georg Fráter ,  Urs Müller

IPC: A61K746

CPC classification number: C11B9/0038 ,  C07C45/512 ,  C07C45/54 ,  C07C45/65 ,  C07C49/587 ,  C07C69/757 ,  C07C49/607

Abstract: Disclosed are compounds of formula I having a strong musk-like odor: In formula I, R1 and R2 are hydrogen or methyl, with the proviso that when R1 is methyl, R2 is hydrogen, and when R1is hydrogen, R2 is methyl. The compounds of formula I may be in the Z- and/or in the E-form. Methods of making the compounds of formula I and compositions containing such compounds are also disclosed.

Abstract translation: 公开了具有强烈麝香样气味的式I化合物：在式I中，R 1和R 2是氢或甲基，条件是当R 1是甲基时，R 2是氢，当R 1是氢时，R 2是甲基。 式I的化合物可以是Z-和/或E-型。 还公开了制备式I化合物的方法和含有这些化合物的组合物。

公开(公告)号：USD472817S1

公开(公告)日：2003-04-08

申请号：US29147093

申请日：2001-08-22

Applicant: Urs Müller

Designer： Urs Müller

公开(公告)号：US06255276B1

公开(公告)日：2001-07-03

申请号：US09504471

申请日：2000-02-16

Applicant: Georg Frater ,  Daniel Helmlinger ,  Urs Müller

Inventor： Georg Frater ,  Daniel Helmlinger ,  Urs Müller

IPC: A61K746

CPC classification number: C07D315/00 ,  C07D313/00 ,  C11B9/0073

Abstract: The invention is concerned with odorant compositions which contain macrocycles, namely 15- to 17-membered compounds of the formula: wherein the dotted line signifies an optional additional bond, X and Y stand for methylene or C2-12-polymethylene, optionally substituted with an additional methyl group, and A signifies hydrogen or methyl in the case of the unsaturated compounds and methyl in the case of the saturated compounds, with the proviso that the unsaturated compounds are present to more than 80% in the cis form when A signifies hydrogen and are present to more than 50% in the cis form when A signifies methyl, with the exception of Z-oxacyclopentadec-6-en-2-one (15-membered ring), Z-oxacycloheptadec-8-en-2-one (17-membered ring), and Z-oxacycloheptadec-11-en-2-one (17-membered ring), a process for the manufacture of the compounds of formula I and the use of the compounds of formula I as odorants.

Abstract translation: 本发明涉及含有大环化合物的加臭剂组合物，即下式的15至17元化合物：其中虚线表示任选的附加键，X和Y代表亚甲基或C2-12-聚亚甲基，任选地被 在不饱和化合物的情况下，A表示氢或甲基，在饱和化合物的情况下表示甲基，条件是当A表示氢时，不饱和化合物以顺式形式存在于80％以上， 当A表示甲基时，以顺式形式存在超过50％，除了Z-氧杂环十六碳-6-烯-2-酮（15元环），Z-氧杂环庚烷-8-烯-2-酮（ 17元环）和Z-氧杂环庚烯十一-11-烯-2-酮（17元环），制备式I化合物的方法和式I化合物作为气味剂的用途。

公开(公告)号：US07884103B2

公开(公告)日：2011-02-08

申请号：US10569682

申请日：2004-08-27

Applicant: Urs Müller

Inventor： Urs Müller

IPC: C07C303/00 ,  C07C307/06 ,  C07D249/08 ,  C07D295/00 ,  A61K31/145

CPC classification number: C07D213/64 ,  A01N41/06 ,  A01N43/653 ,  C07C311/13 ,  C07D231/12 ,  C07D233/54 ,  C07D239/26 ,  C07D249/08 ,  C07D271/10 ,  C07D273/00 ,  C07D277/24 ,  C07D277/34 ,  C07D285/08 ,  C07D295/185

Abstract: The invention relates to N-sulfonyl-α-amino-acetic acid derivatives of the general formula (I): including the optical isomers thereof and mixtures of such isomers, wherein Ar1 and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1 and R2 stand independently of each other for hydrogen, optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C-2C5alkynyl or optionally substituted C3C6Cycloalkyl; R3 designates hydrogen, C-3C5alkenyl, C3-C5 alkynyl or optionally substituted C1-C5alkyl; R4 is optionally substituted C1-C5alkyl, optionally substituted C-2C5alkenyl, C-2C5aklynyl or optionally substituted C-3C6 cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C-2C5alkynyl or optionally substituted C3-C6cycloalkyl; R7 and R8 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; W designates a bridge selected from —O—, —S—, —SO—, —SO2— or is an —NH— or —N(C1-C5alkyl)-bridge; X designates a direct bond or a bridge selected from —O—, —S—, —SO—, —SO2— or is an —NH or —N(C1C5alkyl)-bridge; Y designates —OR9 or NR10R11; a and b independently of each other stand for a number 1, 2 or 3; and c stands for a number zero, 1 or 2; with R9, R10 and R11 being defined according to the claims. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

Abstract translation: 本发明涉及通式（I）的N-磺酰基-α-氨基 - 乙酸衍生物：包括其旋光异构体和这些异构体的混合物，其中Ar 1和Ar 2彼此独立地表示任选取代的芳基或杂芳基 基团，R 1和R 2彼此独立地为氢，任选取代的C 1 -C 5烷基，任选取代的C 2 -C 5烯基，C 2 -C 5炔基或任选取代的C 3 -C 6环烷基; R 3表示氢，C 3 -C 5烯基，C 3 -C 5炔基或任选取代的C 1 -C 5烷基; R 4是任选取代的C 1 -C 5烷基，任选取代的C 2 -C 5烯基，C 2 -C 5烷酰基或任选取代的C 3 -C 6环烷基; R 5和R 6彼此独立地为氢或任选取代的C 1 -C 5烷基，任选取代的C 2 -C 5烯基，C 2 -C 5炔基或任选取代的C 3 -C 6环烷基; R 7和R 8彼此独立地为氢或任选取代的C 1 -C 5烷基，任选取代的C 2 -C 5烯基，C 2 -C 5炔基或任选取代的C 3 -C 6环烷基; W表示选自-O - ， - S - ， - SO - ， - SO 2 - 或-NH-或-N（C 1 -C 5烷基） - 桥; X表示直接键或选自-O - ， - S - ， - SO - ， - SO 2 - 或者是-NH或-N（C 1 -C 5烷基） - 桥; Y表示-OR9或NR10R11; a和b彼此独立，代表数字1,2或3; c代表数字零，1或2; 其中R 9，R 10和R 11如权利要求所定义。 这些化合物具有有用的植物保护性质，并且可有利地用于农业实践中以控制或防止植物病原微生物特别是真菌侵染植物。

公开(公告)号：US06297211B1

公开(公告)日：2001-10-02

申请号：US09502683

申请日：2000-02-11

Applicant: Georg Frater ,  Philip Kraft ,  Urs Müller

Inventor： Georg Frater ,  Philip Kraft ,  Urs Müller

IPC: A61K746

CPC classification number: C11B9/0015 ,  C07C33/025

Abstract: The invention includes (6E)- and (6Z)-isomers of 3,6-dimethyloct-6-en-1-ols and 6-ethyl-3-methyloct-6-en-1-ols and their mixtures. The mixtures are free from their corresponding oct-5-ene double bond isomers. Processes of preparing odorant compositions containing these compositions are also provided.

Abstract translation: 本发明包括3,6-二甲基-6-烯-1-醇和6-乙基-3-甲基-6-烯-1-醇的（6E） - 和（6Z）异构体及其混合物。 该混合物不含相应的辛-5-烯双键异构体。 还提供了制备含有这些组合物的气味组合物的方法。

公开(公告)号：US06667326B1

公开(公告)日：2003-12-23

申请号：US10130492

申请日：2002-05-16

Applicant: Pierre Ducray ,  Jacques Bouvier ,  Urs Müller

Inventor： Pierre Ducray ,  Jacques Bouvier ,  Urs Müller

IPC: C07D41700

CPC classification number: C07D409/12 ,  C07D417/12

Abstract: The invention relates to compounds of the general formula wherein R1, R2, R3, R4, R5, X1, X2, X3, m and n have the significances given in claim 1, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for the control of pests on domestic and farm animals.

Abstract translation: 本发明涉及通式为R 1，R 2，R 3，R 4，R 5，X 1，X 2，X 3，m和n的化合物具有权利要求1中给出的含义，任选其对映异构体。 活性成分具有有利的杀虫特性。 它们特别适合于控制家畜和农场动物的害虫。

公开(公告)号：USD477231S1

公开(公告)日：2003-07-15

申请号：US29174377

申请日：2003-01-16

Applicant: Urs Müller

Designer： Urs Müller