公开(公告)号：US10825676B2

公开(公告)日：2020-11-03

申请号：US16512812

申请日：2019-07-16

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Wenjian Sun

IPC: H01J49/42 ,  H01J49/06

Abstract: A quadrupole mass analyzer according to the present invention optimizes a stability band formation mode of a quadrupole system, so as to facilitate passing of ions and blocking of excessive ions, thereby improving the mass resolution without reducing the ion transmission efficiency. The solution of the present invention avoids the superimposition of high-frequency AC signals needed in the ion two-direction resonance frequency control in the prior art, and can effectively reduce the risk of quadrupole working performance reduction caused by the non-linear distortion of an RF voltage caused by bandwidth limitation in a fast RF circuit. In addition, a scanning speed of an ion-controlled electric field required by the quadrupole mass spectrometry can also be controlled faster because of reduction of limit bandwidth of various needed AC excitation signals. It is advantageous to obtain high-speed quadrupole scanning mass spectrometry performance.

公开(公告)号：US20200027714A1

公开(公告)日：2020-01-23

申请号：US16512812

申请日：2019-07-16

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Wenjian Sun

IPC: H01J49/42 ,  H01J49/06

Abstract: A quadrupole mass analyzer according to the present invention optimizes a stability band formation mode of a quadrupole system, so as to facilitate passing of ions and blocking of excessive ions, thereby improving the mass resolution without reducing the ion transmission efficiency. The solution of the present invention avoids the superimposition of high-frequency AC signals needed in the ion two-direction resonance frequency control in the prior art, and can effectively reduce the risk of quadrupole working performance reduction caused by the non-linear distortion of an RF voltage caused by bandwidth limitation in a fast RF circuit. In addition, a scanning speed of an ion-controlled electric field required by the quadrupole mass spectrometry can also be controlled faster because of reduction of limit bandwidth of various needed AC excitation signals. It is advantageous to obtain high-speed quadrupole scanning mass spectrometry performance.

公开(公告)号：US10763098B2

公开(公告)日：2020-09-01

申请号：US16088553

申请日：2017-03-30

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Wenjian Sun ,  Yupeng Cheng ,  Xiaoqiang Zhang

IPC: H01J49/42 ,  G01N27/62 ,  H01J49/00 ,  H01J49/40

Abstract: An ion optical device includes one or more pairs of confinement electrode units arranged at two sides of a first direction; a power supply device for applying opposite radio-frequency voltages to the paired confinement electrode units respectively and forming thereon DC potentials distributed in a second direction orthogonal to the first direction to form a potential barrier herein over a length portion of the first direction; one first area and one second area positioned at two sides of the potential barrier in the second direction; and a control device connected with the power supply device for controlling an output thereof to change the potential barrier to manipulate the ions transported/stored in the first area being transferred to the second area through the potential barrier in ways based on the mass to charge ratio or mobility of the ions and continue being transported along the first direction.

公开(公告)号：US10020179B2

公开(公告)日：2018-07-10

申请号：US15511561

申请日：2015-11-19

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Jiaqi Shen ,  Wenjian Sun

IPC: H01J49/06 ,  H01J49/36

CPC classification number: H01J49/063 ,  H01J49/062 ,  H01J49/067 ,  H01J49/36

Abstract: A focusing ion guiding apparatus includes: at least one ion guiding inlet and ion guiding outlet connected to each other via a transport axial line; at least one group of focusing electrode structures comprising at least one smooth and non-concave focusing electrode or focusing electrode array to which a focusing voltage is applied, the focusing electrode structure causing the ions transported in the apparatus to be radially focused for many times under the action of a focusing electric field formed by the focusing electrode structure; and a neutral gas flow transported in the axial direction, a diffusion path of the gas flow in an at least partially radial direction relative to the axial direction being blocked by the focusing electrode or its bearing substrate to increase a transport velocity of the gas flow in the axial direction and reduce retention or turbulence of the transported ions.

公开(公告)号：US20150276676A1

公开(公告)日：2015-10-01

申请号：US14735876

申请日：2015-06-10

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Yupeng Cheng ,  Xiaoqiang Zhang ,  Wenjian Sun

IPC: G01N27/62 ,  H01J49/00 ,  H01J49/22

CPC classification number: G01N27/622 ,  G01N27/624 ,  H01J49/004 ,  H01J49/22

Abstract: An ion mobility analyzer, combination device thereof, and ion mobility analysis method. The ion mobility analyzer comprises an electrode system that surrounds the analytical space and a power device that attaches to the electrode system an ion mobility electric potential field that moves along one space axis. During the process of analyzing mobility of ions to be measured, by always placing the ions to be measured in the moving ion mobility electric potential field, and keeping the movement direction of the ion mobility electric potential field consistent with the direction of the electric field on the ions to be measured within the ion mobility electric potential field, theoretically a mobility path of an infinite length can be formed so as to distinguish ions having mobility or ion cross sections that have very small differences.

Abstract translation: 离子迁移率分析仪，其组合装置和离子迁移率分析方法。 离子迁移率分析仪包括围绕分析空间的电极系统和附接到电极系统的沿着一个空间轴移动的离子迁移电位场的功率器件。 在分析被测离子的迁移率的过程中，通过总是将待测离子置于移动离子迁移电势场，并保持离子迁移率电位场的移动方向与电场方向一致 在离子迁移电势场内要测量的离子理论上可以形成无限长度的迁移率路径，以区分具有极小差异的迁移率的离子或离子横截面。

公开(公告)号：US10192728B2

公开(公告)日：2019-01-29

申请号：US15736138

申请日：2016-06-20

Applicant: SHIMADZU CORPORATION

Inventor： Xiaoqiang Zhang ,  Gongyu Jiang ,  Yunqing Huang ,  Jiaqi Shen ,  Wenjian Sun

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/04 ,  H01J49/24 ,  H01J49/10 ,  H01J49/26

Abstract: The disclosure relates to a mass spectrometer and a method applied thereby for reducing ion loss and succeeding stage vacuum load. The mass spectrometer includes an ion source connected via vacuum interfaces, a vacuum chamber and a succeeding stage device; wherein a tubular lens is arranged above a Mach disc formed by a gas flow carrying ions at the vacuum interfaces, so that an ion transfer path is restrained and the ions scattering with the gas flow is reduced. In comparison to a sole reliance on a radio-frequency voltage for focusing ions, the efficiency of ion capture in a jet region is improved by using an aerodynamic lens; and the desolvation efficiency of electrically charged droplets is also improved, thereby further improving the sensitivity of the mass spectrometer. Meanwhile the tubular aerodynamic lens is simple in structure and small in size.

公开(公告)号：US09502228B2

公开(公告)日：2016-11-22

申请号：US14389516

申请日：2013-03-26

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Wenjian Sun

IPC: H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/422 ,  H01J49/423 ,  H01J49/424 ,  H01J49/4245 ,  H01J49/427 ,  H01J49/4285

Abstract: An ion trap analyzer, an ion trap mass spectrometry analysis method, and an ion fragmentation method are provided. The ion trap analyzer includes an ion trapping space enclosed by multiple electrodes (101, 102, 103, 11, 12, 214), where a high-frequency voltage is applied on at least a part of the electrodes, so as to generate, within the trapping space, a trapping electric field dominated by a quadratic field. The apparatus is provided with an ion ejection outlet (200) in at least one direction away from the center of the trap; an alternating voltage signal used for resonant excitation of ion motions is overlaid on an electrode part that is on a side of the ion ejection outlet and closest to the ejection outlet, while no voltage signal that is identical in range and phase with the alternating voltage is applied on at least one remaining electrode part in said direction. With the method, or by further applying, to the remaining electrode part in said direction, a voltage signal that is inverted to the alternating voltage, the orientation of an alternating electric field induced by the excitation alternating voltage signal can be limited, thereby improving the resonance ejection efficiency of the ion trap, reducing, in ion motions, motion coupling between an ejection direction and a non-ejection direction, and improving the viability of selecting the ion trap as a mass analyzer.

Abstract translation: 提供离子阱分析仪，离子阱质谱分析方法和离子碎片化方法。 离子阱分析仪包括由多个电极（101,102,103,11,12,214）包围的离子捕获空间，其中在至少一部分电极上施加高频电压，从而在 捕获空间，由二次场主导的捕获电场。 该设备在远离捕集器中心的至少一个方向上设置有离子喷射出口（200）; 用于离子运动的共振激发的交流电压信号覆盖在离子喷射出口侧并且最靠近喷射出口的电极部分上，而在交变电压范围和相位上没有相同的电压信号是 施加在所述方向上的至少一个剩余电极部分上。 通过该方法，或者通过进一步向所述方向上的剩余电极部分施加反向交流电压的电压信号，可以限制由激励交流电压信号感应的交变电场的取向，从而改善 离子阱的共振喷射效率，减少离子运动，喷射方向和非喷射方向之间的运动耦合，以及提高作为质量分析器选择离子阱的可行性。

公开(公告)号：US09429543B2

公开(公告)日：2016-08-30

申请号：US14735876

申请日：2015-06-10

Applicant: SHIMADZU CORPORATION

Inventor： Gongyu Jiang ,  Yupeng Cheng ,  Xiaoqiang Zhang ,  Wenjian Sun

IPC: H01J49/00 ,  H01J49/34 ,  H01J49/40 ,  G01N27/62 ,  H01J49/22

CPC classification number: G01N27/622 ,  G01N27/624 ,  H01J49/004 ,  H01J49/22

Abstract: An ion mobility analyzer, combination device thereof, and ion mobility analysis method. The ion mobility analyzer comprises an electrode system that surrounds the analytical space and a power device that attaches to the electrode system an ion mobility electric potential field that moves along one space axis. During the process of analyzing mobility of ions to be measured, by always placing the ions to be measured in the moving ion mobility electric potential field, and keeping the movement direction of the ion mobility electric potential field consistent with the direction of the electric field on the ions to be measured within the ion mobility electric potential field, theoretically a mobility path of an infinite length can be formed so as to distinguish ions having mobility or ion cross sections that have very small differences.

Abstract translation: 离子迁移率分析仪，其组合装置和离子迁移率分析方法。 离子迁移率分析仪包括围绕分析空间的电极系统和附接到电极系统的沿着一个空间轴移动的离子迁移电位场的功率器件。 在分析被测离子的迁移率的过程中，通过总是将待测离子置于移动离子迁移电势场，并保持离子迁移率电位场的移动方向与电场方向一致 在离子迁移电势场内要测量的离子理论上可以形成无限长度的迁移率路径，以区分具有极小差异的迁移率的离子或离子横截面。