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公开(公告)号：US06589961B2
公开(公告)日：2003-07-08
申请号：US09934715
申请日：2001-08-22
Applicant: Jerzy Kazimierz Konopa , Barbara Wysocka-Skrzela , Raj Tiwari
Inventor： Jerzy Kazimierz Konopa , Barbara Wysocka-Skrzela , Raj Tiwari
IPC: A61K31473
CPC classification number: C07D219/10 , C07D219/06 , C07D219/12
Abstract: The invention is directed to novel 9-hydroxyalkylamino-, 9-alkoxyalkylamino-1-nitroacridine derivatives. Methods of preparation, pharmaceutical compositions comprising said derivatives and their medical uses are also encompassed by this invention.
Abstract translation: 本发明涉及新的9-羟基烷基氨基 - ，9-烷氧基烷基氨基-1-硝基吖啶衍生物。 制备方法，包含所述衍生物的药物组合物及其医疗用途也包括在本发明中。
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公开(公告)号：US07622478B2
公开(公告)日：2009-11-24
申请号：US09789496
申请日：2001-02-16
Applicant: Raj Tiwari , Daniel Miller , Jerzy Kazimierz Konopa , Barbara Wysocka-Skrzela
Inventor： Raj Tiwari , Daniel Miller , Jerzy Kazimierz Konopa , Barbara Wysocka-Skrzela
IPC: A61K31/473 , C07D219/10 , C07D219/12
CPC classification number: A61K31/47 , A61K31/473 , A61K31/56 , A61K31/34 , A61K31/335 , A61K31/13 , A61K31/12 , A61K2300/00
Abstract: The invention is directed to 1-nitroacridine derivative(s)/tumor inhibitor(s) compositions as well as methods for using said compositions for inhibiting or preventing tumor growth, particularly, prostate cancer cell growth and metastases.
Abstract translation: 本发明涉及1-硝基吖啶衍生物/肿瘤抑制剂组合物以及使用所述组合物抑制或预防肿瘤生长，特别是前列腺癌细胞生长和转移的方法。
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公开(公告)号：US08088569B2
公开(公告)日：2012-01-03
申请号：US10379462
申请日：2003-03-03
Applicant: Raj Tiwari
Inventor： Raj Tiwari
CPC classification number: C12N15/1037 , A61K39/0011 , A61K2039/6043 , A61K2039/622 , C07K16/3069 , C07K2317/34 , C07K2317/622
Abstract: The present invention relates to prophylactic and therapeutic methods of immunization against neoplastic and infectious diseases. The invention provides a method for identification of novel immunogens and compositions of such immunogens that are useful for eliciting immune responses against antigens associated with neoplastic or infectious diseases.
Abstract translation: 本发明涉及针对肿瘤和感染性疾病的免疫的预防和治疗方法。 本发明提供了用于鉴定可用于引发针对与肿瘤性或感染性疾病相关的抗原的免疫应答的免疫原的新型免疫原和组合物的方法。
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公开(公告)号：US08969012B2
公开(公告)日：2015-03-03
申请号：US13341671
申请日：2011-12-30
Applicant: Raj Tiwari
Inventor： Raj Tiwari
CPC classification number: C12N15/1037 , A61K39/0011 , A61K2039/6043 , A61K2039/622 , C07K16/3069 , C07K2317/34 , C07K2317/622
Abstract: The present invention relates to prophylactic and therapeutic methods of immunization against neoplastic and infectious diseases. The invention provides a method for identification of novel immunogens and compositions of such immunogens that are useful for eliciting immune responses against antigens associated with neoplastic or infectious diseases.
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