公开(公告)号：US10067051B2

公开(公告)日：2018-09-04

申请号：US14606812

申请日：2015-01-27

Applicant: CIRECA THERANOSTICS, LLC ,  NORTHEASTERN UNIVERSITY

Inventor： Max Diem ,  Benjamin Bird ,  Milos Miljkovic ,  Stanley H. Remiszewski ,  Clay M. Thompson

IPC: G01N33/48 ,  G01N33/50 ,  G01N21/31 ,  A61B5/00 ,  G01N21/552 ,  G01N21/64 ,  G01N21/65 ,  G06K9/00 ,  G06F19/00 ,  G06T7/30 ,  G01N21/3581 ,  G01N21/35 ,  G06K9/46

CPC classification number: G01N21/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7257 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/552 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2021/6417 ,  G01N2021/653 ,  G01N2201/1293 ,  G01N2201/1296 ,  G06K9/00134 ,  G06K9/00147 ,  G06K2009/4657 ,  G06T7/30 ,  G06T2207/20101 ,  G06T2207/30024 ,  G16H50/20

Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.

公开(公告)号：US09436992B2

公开(公告)日：2016-09-06

申请号：US14678396

申请日：2015-04-03

Applicant: Northeastern University

Inventor： Max Diem ,  Milos Miljkovic ,  Melissa Romeo ,  Benjamin Bird ,  Jennifer Schubert ,  Kostas Papamarkakis

IPC: G06K9/00 ,  G06T7/00 ,  G06T7/40 ,  G06K9/52

CPC classification number: G06T7/0012 ,  G06K9/00147 ,  G06K9/522 ,  G06T7/42 ,  G06T7/90 ,  G06T2207/10056 ,  G06T2207/20021 ,  G06T2207/30004 ,  G06T2207/30024

Abstract: Embodiments of the present disclosure provides improved methods for determining the presence of abnormalities in exfoliated cells. In one embodiment, the present disclosure provides methods for reconstructing cellular spectrum of a cell sample by creating a spectral map of the cellular sample, generating a binary mask of the spectral map, removing edge artifacts from each cell, and co-adding spectral data of each pixel corresponding to the cell to reconstruct the spectrum of each cell.

公开(公告)号：US09047662B2

公开(公告)日：2015-06-02

申请号：US13847591

申请日：2013-03-20

Applicant: Northeastern University

Inventor： Max Diem ,  Milos Miljkovic ,  Melissa Romeo ,  Benjamin Bird ,  Jennifer Schubert ,  Kostas Papamarkakis

IPC: G06K9/00 ,  G06T7/00 ,  G06T7/40

CPC classification number: G06T7/0012 ,  G06K9/00147 ,  G06K9/522 ,  G06T7/42 ,  G06T7/90 ,  G06T2207/10056 ,  G06T2207/20021 ,  G06T2207/30004 ,  G06T2207/30024

Abstract: Embodiments of the present disclosure provides improved methods for determining the presence of abnormalities in exfoliated cells. In one embodiment, the present disclosure provides methods for reconstructing cellular spectrum of a cell sample by creating a spectral map of the cellular sample, generating a binary mask of the spectral map, removing edge artifacts from each cell, and co-adding spectral data of each pixel corresponding to the cell to reconstruct the spectrum of each cell.

Abstract translation: 本公开的实施方案提供了用于确定脱落细胞中异常的存在的改进方法。 在一个实施方案中，本公开提供了通过产生细胞样品的光谱图来重建细胞样品的细胞谱的方法，产生光谱图的二值掩模，从每个细胞去除边缘伪像，以及共同添加光谱数据 每个像素对应于该单元以重建每个单元的频谱。