公开(公告)号：US09549956B2

公开(公告)日：2017-01-24

申请号：US14263306

申请日：2014-04-28

Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA

Inventor： Daisuke Fujiwara ,  Kenta Jonai ,  Tetsu Sugimura

IPC: A61K35/74 ,  A61K35/744 ,  A23C9/123 ,  A61K35/747 ,  C12N1/20 ,  A23C19/06 ,  A61K31/711 ,  C12N15/74 ,  C12Q1/68 ,  G01N33/68 ,  A23C19/032

CPC classification number: A61K35/744 ,  A23C9/123 ,  A23C9/1236 ,  A23C19/0323 ,  A23C19/062 ,  A23L33/135 ,  A23Y2240/41 ,  A61K9/0053 ,  A61K31/711 ,  A61K35/747 ,  C12N1/20 ,  C12N15/746 ,  C12Q1/6809 ,  C12R1/01 ,  G01N33/6866

Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

Abstract translation: 本发明提供一种IFN诱导剂，其包含作为活性成分的乳酸菌并能够诱导IFN产生，包含该诱导剂的免疫增强剂或抗病毒感染的预防剂，以及包含该IFN诱导剂的食品或饮品， 诱导活性，免疫增强活性或针对病毒感染的预防活性。 用于诱导IFN产生的药物包括作为活性成分的可激活浆细胞样树突状细胞（pDC）并促进IFN产生的乳酸菌，例如乳球乳杆菌NBRC100934，乳酸乳球菌亚种。 cremoris JCM16167，乳酸乳球菌亚种 cremoris NBRC100676，乳酸乳球菌亚种 大麦草JCM1180，乳酸乳球菌亚种 大麦草JCM11040，乳酸乳球菌亚种 乳酸菌NBRC12007，乳酸乳球菌亚种 乳酸菌NRIC1150，乳酸乳球菌亚种 乳酸菌JCM5805，乳酸乳球菌亚种 乳酸菌JCM20101，乳酸列表克鲁维酵母NBRC12455，乳酸列表氨酸亮氨酸NRIC1540，侏儒球菌JCM5886或嗜热链球菌TA-45。

公开(公告)号：US10220060B2

公开(公告)日：2019-03-05

申请号：US15367649

申请日：2016-12-02

Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA

Inventor： Daisuke Fujiwara ,  Kenta Jonai ,  Tetsu Sugimura

IPC: A61K35/744 ,  A23C19/06 ,  A23C9/123 ,  A61K35/747 ,  C12N1/20 ,  A61K31/711 ,  C12N15/74 ,  C12Q1/6809 ,  G01N33/68 ,  A23C19/032 ,  A23L33/135 ,  A61K9/00 ,  C12R1/01

Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

公开(公告)号：US11224623B2

公开(公告)日：2022-01-18

申请号：US16290581

申请日：2019-03-01

Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA

Inventor： Daisuke Fujiwara ,  Kenta Jonai ,  Tetsu Sugimura

IPC: A61K35/744 ,  A23L33/135 ,  A23C9/123 ,  A61K35/747 ,  C12N1/20 ,  A23C19/032 ,  A23C19/06 ,  A61K31/711 ,  C12N15/74 ,  C12Q1/6809 ,  G01N33/68 ,  A61K9/00 ,  C12R1/01

Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

公开(公告)号：US10603377B2

公开(公告)日：2020-03-31

申请号：US15770869

申请日：2016-10-25

Applicant: Kirin Holdings Kabushiki Kaisha

Inventor： Hiroaki Suzuki ,  Kenta Jounai ,  Daisuke Fujiwara

IPC: A61K35/747 ,  A61K39/12 ,  A61K39/39 ,  A61K39/00 ,  A23L33/135 ,  C12N1/20 ,  A61K39/145 ,  A61K39/02 ,  C12N7/00 ,  A61K9/00 ,  A61K35/00 ,  A23L33/10

Abstract: Provided are a composition and a food or drink, having the effect of enhancing an immune response to an antigen, which is administered by another route such as subcutaneous injection, by orally administering to a subject, lactic acid bacteria, a culture thereof, a treated product thereof, or a composition comprising the same.An oral ingestion composition, which comprises a lactic acid bacterium strain that is Lactococcus lactis subsp. lactis enhancing the proliferation of cytotoxic T lymphocytes (CTL) and the generation of antibodies, or a culture or treated product thereof, and is used in combination with an antigen as a vaccine, wherein the oral ingestion composition is for use in enhancing the proliferation of cytotoxic T lymphocytes (CTL) specific to the antigen and the generation of antibodies specific to the antigen.

公开(公告)号：US11944657B2

公开(公告)日：2024-04-02

申请号：US17548904

申请日：2021-12-13

Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA

Inventor： Daisuke Fujiwara ,  Kenta Jonai ,  Tetsu Sugimura

IPC: A61K35/744 ,  A23C9/123 ,  A23C19/032 ,  A23C19/06 ,  A23L33/135 ,  A61K9/00 ,  A61K31/711 ,  A61K35/747 ,  C12N1/20 ,  C12N15/74 ,  C12Q1/6809 ,  C12R1/01 ,  G01N33/68

CPC classification number: A61K35/744 ,  A23C9/123 ,  A23C9/1236 ,  A23C19/0323 ,  A23C19/062 ,  A23L33/135 ,  A61K9/0053 ,  A61K31/711 ,  A61K35/747 ,  C12N1/20 ,  C12N1/205 ,  C12N15/746 ,  C12Q1/6809 ,  G01N33/6866 ,  A23V2400/231 ,  C12R2001/01

Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

公开(公告)号：US11890309B2

公开(公告)日：2024-02-06

申请号：US17838698

申请日：2022-06-13

Applicant: Kirin Holdings Kabushiki Kaisha

Inventor： Toshihide Kurihara ,  Yuji Morita ,  Kenta Jonai ,  Daisuke Fujiwara

IPC: A61K35/747 ,  A23L33/135 ,  A61P27/02

CPC classification number: A61K35/747 ,  A23L33/135 ,  A61P27/02

Abstract: An object of the present invention is to provide a composition for preventing visual dysfunction caused by exposure to light, such as so-called blue light. The present invention provides a composition comprising a lactic acid bacterium as an active ingredient for use in suppressing or improving conditions caused by retinal inflammation resulting from light damage. Eye discomfort is an exemplary condition caused by retinal inflammation resulting from light damage.

公开(公告)号：US20140234379A1

公开(公告)日：2014-08-21

申请号：US14263306

申请日：2014-04-28

Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA

Inventor： Daisuke Fujiwara ,  Kenta JONAI ,  Tetsu SUGIMURA

IPC: A61K35/74

CPC classification number: A61K35/744 ,  A23C9/123 ,  A23C9/1236 ,  A23C19/0323 ,  A23C19/062 ,  A23L33/135 ,  A23Y2240/41 ,  A61K9/0053 ,  A61K31/711 ,  A61K35/747 ,  C12N1/20 ,  C12N15/746 ,  C12Q1/6809 ,  C12R1/01 ,  G01N33/6866

Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

Abstract translation: 本发明提供一种IFN诱导剂，其包含作为活性成分的乳酸菌并能够诱导IFN产生，包含该诱导剂的免疫增强剂或抗病毒感染的预防剂，以及包含该IFN诱导剂的食品或饮料，并含有IFN- 诱导活性，免疫增强活性或针对病毒感染的预防活性。 用于诱导IFN产生的药物包括作为活性成分的可激活浆细胞样树突状细胞（pDC）并促进IFN产生的乳酸菌，例如乳球乳杆菌NBRC100934，乳酸乳球菌亚种。 cremoris JCM16167，乳酸乳球菌亚种 cremoris NBRC100676，乳酸乳球菌亚种 大麦草JCM1180，乳酸乳球菌亚种 大麦草JCM11040，乳酸乳球菌亚种 乳酸菌NBRC12007，乳酸乳球菌亚种 乳酸菌NRIC1150，乳酸乳球菌亚种 乳酸菌JCM5805，乳酸乳球菌亚种 乳酸菌JCM20101，乳酸列表克鲁维酵母NBRC12455，乳酸列表氨酸亮氨酸NRIC1540，侏儒球菌JCM5886或嗜热链球菌TA-45。