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公开(公告)号：US08623599B2
公开(公告)日：2014-01-07
申请号：US12451943
申请日：2008-06-06
Applicant: Theo Devos , Cathy Lofton-Day , Andrew Sledziewski , Fabian Model , Michael Krouse , Jesse Ho , Matthias Schuster , Juergen Distler , Reimo Tetzner
Inventor： Theo Devos , Cathy Lofton-Day , Andrew Sledziewski , Fabian Model , Michael Krouse , Jesse Ho , Matthias Schuster , Juergen Distler , Reimo Tetzner
IPC: C12Q1/68
CPC classification number: C12Q1/6813 , C12Q1/6806 , C12Q1/6827 , C12Q1/6844 , C12Q2523/125
Abstract: Aspects of the invention relate to composition and methods for the providing of DNA for methylation analysis that is in particular suitable to be applied in reference laboratories. Further 5 aspects of the invention relate to composition and methods for the highly specific and sensitive methylation analysis of the Septin 9 gene also in particular suitable to be applied in reference laboratories.
Abstract translation: 本发明的方面涉及提供用于甲基化分析的DNA的组合物和方法，其特别适用于参考实验室。 本发明的另外5个方面涉及用于Septin 9基因的高度特异性和敏感的甲基化分析的组合物和方法，特别适用于参考实验室。
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2.发明授权公开(公告)号：US07749702B2
公开(公告)日：2010-07-06
申请号：US11405322
申请日：2006-04-17
Applicant: Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
Inventor： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
Abstract translation: 本发明提供用于检测或检测和鉴别肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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3.发明申请Methods and computer program products for the quality control of nucleic acid assay 审中-公开方法和计算机程序产品，用于核酸测定的质量控制公开(公告)号：US20050255467A1
公开(公告)日：2005-11-17
申请号：US10509449
申请日：2003-03-28
Applicant: Peter Adorjan , Fabian Model , Thomas Konig , Christian Piepenbrock , Klaus Junemann , Matthias Burger , Susanne Schwenke
Inventor： Peter Adorjan , Fabian Model , Thomas Konig , Christian Piepenbrock , Klaus Junemann , Matthias Burger , Susanne Schwenke
Abstract: The disclosed invention provides methods and computer program products for the improved verification and controlling of assays for the analysis of nucleic acid variations by means of statistical process control. The invention is characterised in that variables of each experiment are monitored by measuring deviations of said variables from a reference data set and wherein said experiments or batches thereof are indicated as unsuitable for further interpretation if they exceed predetermined limits.
Abstract translation: 所公开的发明提供了用于通过统计过程控制来改进对核酸变异分析的测定的验证和控制的方法和计算机程序产品。 本发明的特征在于，通过测量所述变量与参考数据集的偏差来监测每个实验的变量，并且其中所述实验或其批次被指示为不适合进一步解释，如果它们超过预定限度。
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公开(公告)号：US10731215B2
公开(公告)日：2020-08-04
申请号：US11910887
申请日：2006-04-17
Applicant: Matthias Ballhause , Kurt Berlin , Theo De Vos , Dimo Dietrich , Volker Liebenberg , Catherine Lofton-Day , Joe Lograsso , Jennifer Maas , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner
Inventor： Matthias Ballhause , Kurt Berlin , Theo De Vos , Dimo Dietrich , Volker Liebenberg , Catherine Lofton-Day , Joe Lograsso , Jennifer Maas , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner
IPC: C12Q1/68 , C12Q1/6883 , C12N15/10 , C12Q1/6806 , C07H21/04
Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA. Other aspects provide methods for determining the presence or absence of methylation of at least one cytosine, or a series of cytosines in cis, in human DNA of a blood sample, a plasma sample, a serum sample or a urine sample from a human individual.
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公开(公告)号：US07381808B2
公开(公告)日：2008-06-03
申请号：US10172086
申请日：2002-06-13
Applicant: Juergen Distler , Fabian Model , Peter Adorjan
Inventor： Juergen Distler , Fabian Model , Peter Adorjan
CPC classification number: C12Q1/6827 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C12Q1/6886 , C12Q2600/154 , C40B40/06 , C12Q2565/627 , C12Q2523/125
Abstract: The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in characterisation, classification, differentiation, diagnosis and therapy of prostate lesions.
Abstract translation: 本发明涉及化学修饰的基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于确定用于表征，分类的基因的遗传和/或表观遗传学参数的方法 ，前列腺损伤的分化，诊断和治疗。
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Patent Agency Ranking
公开(公告)号：US09695478B2
公开(公告)日：2017-07-04
申请号：US12779856
申请日：2010-05-13
Applicant: Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
Inventor： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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7.发明申请METHOD FOR PREDICTING CLINICAL BENEFIT IN THE TREATMENT OF NEURODEVELOPMENTAL, NEUROLOGICAL OR NEUROPSYCHIATRIC DISORDERS 审中-公开预防神经发育，神经病学或神经病学疾病治疗临床益处的方法公开(公告)号：US20140065610A1
公开(公告)日：2014-03-06
申请号：US13590211
申请日：2012-08-21
Applicant: Laurent Essioux , Carsten Horn , Johann Karl , Peter Kastner , Fabian Model , Giuseppe Palermo , Christina Rabe , Daniel Umbricht , Gabriel Vargas , Anne Vogt
Inventor： Laurent Essioux , Carsten Horn , Johann Karl , Peter Kastner , Fabian Model , Giuseppe Palermo , Christina Rabe , Daniel Umbricht , Gabriel Vargas , Anne Vogt
CPC classification number: G01N33/6896 , C12Q1/6883 , G01N21/76 , G01N33/543 , G01N33/54366
Abstract: An in vitro method of predicting whether a patient, having a neurodevelopmental, neurological or neuropsychiatric disorder, will derive a clinical benefit if treated with a glycine reuptake inhibitor (GRI), via determination of the protein concentration of one, two, three, four five or six members of the complement factor H family or a mixture or a combination thereof and comparison against a representative value, wherein a higher value of the protein concentration in the patient's sample against the representative value is indicative of a patient whom will derive clinical benefit from treatment with GRI.
Abstract translation: 如果用甘氨酸再摄取抑制剂（GRI）进行治疗，预测具有神经发育，神经系统或神经精神障碍的患者是否将获得临床益处的体外方法，通过测定一，二，三，四五 或六个成员的补体因子H家族或其混合物或其组合，并与代表性值进行比较，其中患者样品中的蛋白质浓度的较高值代表代表性值，指示将从 用GRI治疗。
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公开(公告)号：US20110059432A1
公开(公告)日：2011-03-10
申请号：US11910887
申请日：2006-04-17
Applicant: Matthias Ballhause , Kurt Berlin , Theo De Vos , Dimo Dietrich , Volker Liebenberg , Catherine Lofton-Day , Joe Lograsso , Jennifer Maas , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner
Inventor： Matthias Ballhause , Kurt Berlin , Theo De Vos , Dimo Dietrich , Volker Liebenberg , Catherine Lofton-Day , Joe Lograsso , Jennifer Maas , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner
Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA.
Abstract translation: 本发明的方面涉及从远程样品提供DNA片段的组合物和方法。 在特定方面，提供了包含DNA的远程样品，从远程样品中分离DNA，并以允许甲基化和非甲基化胞嘧啶分化的方式处理分离的DNA。 另外，具体实施方案提供了用于从远程样品衍生的DNA的甲基化分析的组合物和方法。 其他方面提供了亚硫酸氢盐处理的DNA的全基因组扩增的组合物和方法。
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9.发明申请公开(公告)号：US20060286576A1
公开(公告)日：2006-12-21
申请号：US11405322
申请日：2006-04-17
Applicant: Cathy Lofton-Day , Andrew Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
Inventor： Cathy Lofton-Day , Andrew Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
Abstract translation: 本发明提供用于检测或检测和鉴别肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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10.发明授权公开(公告)号：US08900829B2
公开(公告)日：2014-12-02
申请号：US13096932
申请日：2011-04-28
Applicant: Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
Inventor： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
Abstract translation: 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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