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    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
    2.
    发明授权
    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis 有权

    公开(公告)号：US11476106B2

    公开(公告)日：2022-10-18

    申请号：US17225622

    申请日：2021-04-08

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/04 ,  G01N1/40 ,  H01J49/16 ,  G01N30/00

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

    Electromagnetic Assemblies for Processing Fluids
    3.
    发明申请
    Electromagnetic Assemblies for Processing Fluids 审中-公开

    公开(公告)号：US20200011773A1

    公开(公告)日：2020-01-09

    申请号：US16480491

    申请日：2018-01-23

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: G01N1/38 ,  G01N1/40 ,  B03C1/01 ,  B03C1/033 ,  B03C1/28 ,  B01F13/08

    Abstract: Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.

    Electromagnetic coil assembly structure for processing fluids and methods for making same
    4.
    发明授权
    Electromagnetic coil assembly structure for processing fluids and methods for making same 有权

    公开(公告)号：US12135969B2

    公开(公告)日：2024-11-05

    申请号：US17261811

    申请日：2019-07-19

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu ,  Stanislaw Potyrala ,  Alex Tsipirovich

    IPC: G06F9/30 ,  B03C1/01 ,  B03C1/28 ,  G01N35/00

    Abstract: Electromagnetic systems and corresponding methods for assembling the electromagnetic systems are described. The electromagnetic systems can be used in fluid processing systems that include a plurality of fluid containers, each configured to define a fluid chamber that receives a fluid and a plurality of magnetic particles, and a plurality of electromagnets configured to generate a magnetic field within at least one of the plurality of the fluid containers. The fluid processing system can also include a PCB board that supplies the electromagnets with electrical current by establishing an electrical connection between electrical contact terminals included on the PCB board and spring loaded connections included on each electromagnet. A control component controls the electromagnetic field generated by each electromagnet to generate a plurality of magnetic field gradients within the at least one fluid container sufficient to magnetically influence the plurality of magnetic particles within the fluid in each fluid container.

    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
    5.
    发明授权
    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis 有权

    公开(公告)号：US11817302B2

    公开(公告)日：2023-11-14

    申请号：US18046986

    申请日：2022-10-17

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/04 ,  G01N1/40 ,  H01J49/16 ,  G01N30/00

    CPC classification number: H01J49/0495 ,  G01N1/405 ,  H01J49/0404 ,  H01J49/165 ,  G01N2030/009

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

    Open port probe interfaces
    7.
    发明授权
    Open port probe interfaces 有权

    公开(公告)号：US11676806B2

    公开(公告)日：2023-06-13

    申请号：US17260734

    申请日：2019-07-17

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold

    IPC: H01J49/04

    CPC classification number: H01J49/0409 ,  H01J49/0459

    Abstract: Integrated system for delivering sample to a mass spectrometer, which includes a chamber extending from a top to bottom end, an open port probe disposed in the chamber such that an open end of the probe, which is configured for receiving a sample, is positioned in proximity to top end of the chamber. The system can further include a solvent inlet port coupled to said chamber for receiving a solvent and directing said solvent to said probe, and a solvent outlet port for receiving a flow of the solvent from the open port probe and directing the received solvent out of the chamber. The system can also include an adapter for receiving a sample holder having an outlet port, the adapter is releasable and replaceable and couple with chamber to align the outlet port of sample holder with open end of probe for delivering sample to the probe.

    Open Port Probe Interfaces
    9.
    发明申请
    Open Port Probe Interfaces 有权

    公开(公告)号：US20210265152A1

    公开(公告)日：2021-08-26

    申请号：US17260734

    申请日：2019-07-17

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold

    IPC: H01J49/04

    Abstract: Integrated system for delivering sample to a mass spectrometer, which includes a chamber extending from a top to bottom end, an open port probe disposed in the chamber such that an open end of the probe, which is configured for receiving a sample, is positioned in proximity to top end of the chamber. The system can further include a solvent inlet port coupled to said chamber for receiving a solvent and directing said solvent to said probe, and a solvent outlet port for receiving a flow of the solvent from the open port probe and directing the received solvent out of the chamber. The system can also include an adapter for receiving a sample holder having an outlet port, the adapter is releasable and replaceable and couple with chamber to align the outlet port of sample holder with open end of probe for delivering sample to the probe.

    System and method for the acoustic loading of an analytical instrument using a continuous flow sampling probe
    10.
    发明授权
    System and method for the acoustic loading of an analytical instrument using a continuous flow sampling probe 有权

    公开(公告)号：US12154776B2

    公开(公告)日：2024-11-26

    申请号：US18121550

    申请日：2023-03-14

    Applicant: LABCYTE INC. ,  DH Technologies Development Pte. Ltd.

    Inventor： Sammy Datwani ,  Don W. Arnold ,  Lucien P. Ghislain ,  Chang Liu ,  Thomas Covey

    IPC: H01J49/04 ,  B01L3/02 ,  G01N29/02 ,  G01N29/22 ,  H01J49/00 ,  H01J49/16

    Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

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