公开(公告)号：US20130131472A1

公开(公告)日：2013-05-23

申请号：US13738905

申请日：2013-01-10

Applicant: Chromologic LLC

Inventor： Naresh Menon

IPC: A61B5/1455 ,  A61B3/00 ,  A61B5/145

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4869

Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

Abstract translation: 一种用于测量受试者中分析物浓度水平的装置。 该装置包括：光源，被配置为用基本上与眼睛表面相切的角度具有基本上宽的照明光谱的入射光来照射被检体的眼睛的前部区域的至少一部分; 被配置为用于检测来自眼睛的前部区域的至少一部分的反射光的光学收集器; 分析器，被配置为分析检测到的反射光; 以及处理器，其被配置为基于所分析的反射光来确定所述对象中的分析物浓度水平。

公开(公告)号：US20180280832A1

公开(公告)日：2018-10-04

申请号：US15943592

申请日：2018-04-02

Applicant: ChromoLogic LLC

Inventor： Naresh Menon ,  Peter Bui ,  Cheryl Tan

IPC: B01D15/36 ,  G01N1/30 ,  G01N1/40 ,  B01D71/16 ,  B01J20/286

CPC classification number: B01D15/362 ,  B01D63/087 ,  B01D69/12 ,  B01D71/027 ,  B01D71/10 ,  B01D71/16 ,  B01D71/28 ,  B01D2313/04 ,  B01D2313/105 ,  B01J20/286 ,  B01L2300/0681 ,  G01N1/30 ,  G01N1/38 ,  G01N1/4005 ,  G01N1/405 ,  G01N2001/2826 ,  G01N2001/381 ,  G01N2001/383 ,  G01N2001/4011 ,  G01N2001/4016

Abstract: An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample. The apparatus includes an assembly having sides forming a hollow shape having a first opening at one end and second opening at the opposite end, a sample mixing chamber positioned adjacent the first opening within the assembly, the sample mixing chamber from which a flow of the biological fluid sample is actuated in a direction from the sample mixing chamber to the first matrix layer, the sample mixing chamber being in a direction downstream of the first opening, a first valve positioned between the sample mixing chamber and the first matrix layer, the first valve configured to control the flow to the first matrix layer, a first input in fluid communication with the sample mixing chamber and positioned upstream of the first valve, a second input positioned between the first matrix layer and the second matrix layer, and a second valve positioned between the second matrix layer and the second opening, the second valve configured to control the flow to the second matrix layer.

公开(公告)号：US10717022B2

公开(公告)日：2020-07-21

申请号：US15943592

申请日：2018-04-02

Applicant: ChromoLogic LLC

Inventor： Naresh Menon ,  Peter Bui ,  Cheryl Tan

IPC: G01N1/40 ,  B01D63/08 ,  B01D15/36 ,  G01N1/30 ,  B01D71/16 ,  B01J20/286 ,  G01N1/38 ,  B01D69/12 ,  B01D71/28 ,  B01D71/02 ,  B01D71/10 ,  G01N1/28

Abstract: An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample. The apparatus includes an assembly having sides forming a hollow shape having a first opening at one end and second opening at the opposite end, a sample mixing chamber positioned adjacent the first opening within the assembly, the sample mixing chamber from which a flow of the biological fluid sample is actuated in a direction from the sample mixing chamber to the first matrix layer, the sample mixing chamber being in a direction downstream of the first opening, a first valve positioned between the sample mixing chamber and the first matrix layer, the first valve configured to control the flow to the first matrix layer, a first input in fluid communication with the sample mixing chamber and positioned upstream of the first valve, a second input positioned between the first matrix layer and the second matrix layer, and a second valve positioned between the second matrix layer and the second opening, the second valve configured to control the flow to the second matrix layer.

公开(公告)号：US08666465B2

公开(公告)日：2014-03-04

申请号：US13738905

申请日：2013-01-10

Applicant: Chromologic LLC

Inventor： Naresh Menon

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4869

Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

Abstract translation: 一种用于测量受试者中分析物浓度水平的装置。 该装置包括：光源，被配置为用基本上与眼睛表面相切的角度具有基本上宽的照明光谱的入射光来照射被检体的眼睛的前部区域的至少一部分; 被配置为用于检测来自眼睛的前部区域的至少一部分的反射光的光学收集器; 分析器，被配置为分析检测到的反射光; 以及处理器，其被配置为基于所分析的反射光来确定所述对象中的分析物浓度水平。

公开(公告)号：US20160349156A9

公开(公告)日：2016-12-01

申请号：US13829824

申请日：2013-03-14

Applicant: ChromoLogic LLC

Inventor： Naresh Menon ,  Peter Bui ,  Cheryl Tan

IPC: G01N1/31

CPC classification number: G01N1/31 ,  G01N1/405

Abstract: An apparatus and method for moiety specific sample extraction from a complex sample matrix in a flow through process is provided. The present invention relates to an integrated membrane for separation and preservation of biomolecules. Classes of biomolecules, for example, those in blood, can be separated and preserved. For blood separation, the apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity thereof. The housing also includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting substantially all cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion. The method includes passing fluid through a matrix; collecting substantially all cells from the fluid in a layer of the matrix; adsorbing protein from the fluid in a layer of the matrix; and adsorbing nucleic acid from the fluid in a layer of the matrix.

Abstract translation: 提供了一种用于在流动过程中从复杂样品基质提取部分特异性样品的装置和方法。 本发明涉及用于分离和保存生物分子的一体化膜。 生物分子的类别，例如血液中的那些，可以被分离和保存。 为了分离血液，该装置包括具有矩阵部分的壳体和设置在其内腔内的流体收集部分。 壳体还包括允许进入内腔的孔。 该装置还包括设置在矩阵部分内的矩阵。 基质包括用于从流体中收集基本上所有细胞的第一层，用于蛋白质吸附的第二层和用于核酸吸附的第三层。 流体通过孔进入壳体，穿过基质并进入流体收集部分。 该方法包括使流体通过基质; 在基质层中从流体中收集基本上所有的细胞; 从基质层中的流体吸附蛋白质; 并在基质层中的流体中吸附核酸。

公开(公告)号：US20140272925A1

公开(公告)日：2014-09-18

申请号：US13830065

申请日：2013-03-14

Applicant: CHROMOLOGIC LLC

Inventor： Naresh Menon ,  Gregory Bearman ,  Cheryl Tan ,  Julian Down

IPC: B01L3/00 ,  G01N33/49

CPC classification number: B01L3/5021 ,  B01L2300/087 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0677 ,  G01N33/491

Abstract: A blood fractionating apparatus that enables aseptic fractionation and storing of fractionated blood components, comprises a centrifuge tube including three chambers separated by constricted sealable passages, an open operative upper end chamber, a closed operative lower end chamber and a middle chamber defined between the upper end chamber and the lower end chamber and connected by means of the sealable passages. A stopper with a flapper valve is provided at the opening of the upper end chamber to control flow of fluid to and from the chambers. This apparatus enables separating the chambers to obtain a hermetically sealed operative lower chamber containing the corpuscle component and a hermetically sealed middle chamber containing the plasma component that can be stored at ambient temperature.

Abstract translation: 能够进行无菌分馏和储存分馏血液成分的血液分馏装置包括离心管，其包括由收缩的可密封通道分隔开的三个室，打开的有效上端室，封闭的可操作的下端室和中间室， 室和下端室，并通过可密封通道连接。 具有挡板阀的塞子设置在上端室的开口处，以控制流体进出室的流动。 该装置能够分离室以获得容纳微粒成分的气密操作下室，以及容纳可在环境温度下储存的等离子体组分的气密密封的中间室。

公开(公告)号：US20190380870A1

公开(公告)日：2019-12-19

申请号：US16442260

申请日：2019-06-14

Applicant: ChromoLogic LLC

Inventor： Jawchyng Lormen Lue ,  Juan Pablo Cardenas ,  Ronald Robnett ,  Naresh Menon ,  Evan Tsang ,  Ed Burns

IPC: A61F9/00 ,  A61K9/00 ,  A61F9/007

Abstract: An applicator includes a body defining a cavity configured to receive a container, a nozzle at an upper portion of the body, the nozzle comprising, an outer nozzle portion having a circular shape and defining a plurality of overflow channels, an inner nozzle portion having a circular shape and spaced from the outer nozzle portion by a circular channel, the inner nozzle portion including a ridge around a periphery of the inner nozzle portion and a cleft defining the ridge, the cleft and the ridge each having circular shapes, and a plurality of connectors extending through the channel and connecting the inner nozzle portion to the outer nozzle portion, wherein the overflow channels extend radially outward from the channel, and a plunger including a shaft and a base, the shaft being movable within the cavity and configured to guide the container toward the nozzle.

公开(公告)号：US09933343B2

公开(公告)日：2018-04-03

申请号：US13829824

申请日：2013-03-14

Applicant: ChromoLogic LLC

Inventor： Naresh Menon ,  Peter Bui ,  Cheryl Tan

IPC: G01N1/40 ,  G01N1/31

CPC classification number: G01N1/31 ,  G01N1/405

Abstract: The apparatus of the present invention comprises an integrated membrane for separation and preservation of biomolecules. Biomolecules, such as those in blood, can be separated and preserved. The apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity. The housing further includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion. Cells from the fluid in a layer of the matrix are collected; adsorbing protein from the fluid in a layer of the matrix; and adsorbing nucleic acid from the fluid in a layer of the matrix.

公开(公告)号：US20140273058A1

公开(公告)日：2014-09-18

申请号：US13829824

申请日：2013-03-14

Applicant: ChromoLogic LLC

Inventor： Naresh Menon ,  Peter Bui ,  Cheryl Tan

IPC: G01N1/31

CPC classification number: G01N1/31 ,  G01N1/405

Abstract: An apparatus and method for moiety specific sample extraction from a complex sample matrix in a flow through process is provided. The present invention relates to an integrated membrane for separation and preservation of biomolecules. Classes of biomolecules, for example, those in blood, can be separated and preserved. For blood separation, the apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity thereof. The housing also includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting substantially all cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion. The method includes passing fluid through a matrix; collecting substantially all cells from the fluid in a layer of the matrix; adsorbing protein from the fluid in a layer of the matrix; and adsorbing nucleic acid from the fluid in a layer of the matrix.

Abstract translation: 提供了一种用于在流动过程中从复杂样品基质提取部分特异性样品的装置和方法。 本发明涉及用于分离和保存生物分子的一体化膜。 生物分子的类别，例如血液中的那些，可以被分离和保存。 为了分离血液，该装置包括具有矩阵部分的壳体和设置在其内腔内的流体收集部分。 壳体还包括允许进入内腔的孔。 该装置还包括设置在矩阵部分内的矩阵。 基质包括用于从流体中收集基本上所有细胞的第一层，用于蛋白质吸附的第二层和用于核酸吸附的第三层。 流体通过孔进入壳体，穿过基质并进入流体收集部分。 该方法包括使流体通过基质; 在基质层中从流体中收集基本上所有的细胞; 从基质层中的流体吸附蛋白质; 并在基质层中的流体中吸附核酸。