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公开(公告)号：US20170036027A1
公开(公告)日：2017-02-09
申请号：US15278186
申请日：2016-09-28
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen B. Ruble , Jason J. Hamann
CPC classification number: A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
Abstract translation: 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。
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公开(公告)号：US09061136B2
公开(公告)日：2015-06-23
申请号：US14151302
申请日：2014-01-09
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen B. Ruble , Jason J. Hamann
CPC classification number: A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
Abstract translation: 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。
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公开(公告)号：US09014819B2
公开(公告)日：2015-04-21
申请号：US14077524
申请日：2013-11-12
Applicant: Cardiac Pacemakers, Inc.
Inventor： Kent Lee , Quan Ni , Jesse W. Hartley , Jeffrey E. Stahmann
IPC: A61N1/00 , A61N1/36 , A61B5/08 , A61B5/113 , A61M16/00 , A61N1/365 , A61B5/00 , A61M16/06 , A61N1/362
CPC classification number: A61N1/36135 , A61B5/0809 , A61B5/113 , A61B5/4035 , A61B5/4519 , A61B5/4806 , A61B5/4809 , A61M16/0051 , A61M16/024 , A61M16/06 , A61M2205/054 , A61M2205/3569 , A61M2205/3592 , A61M2230/04 , A61M2230/10 , A61M2230/60 , A61M2230/63 , A61N1/3601 , A61N1/362 , A61N1/36514
Abstract: Various approaches to detecting arousals from sleep involve generating signals modulated by muscle tone, brainwave activity, and/or other nervous system activity associated with a patient's autonomic arousal response. Generating the signals and/or detecting autonomic arousals from sleep may be performed using an implantable device. Arousal information may be useful to identify sleep disorder events associated with arousals from sleep, for diagnostic purposes, and/or for therapy adjustment.
Abstract translation: 从睡眠中检测觉醒的各种方法涉及产生由肌肉紧张度，脑波活动和/或与患者的自主觉醒反应相关的其他神经系统活动调制的信号。 可以使用可植入装置来执行从睡眠产生信号和/或检测自主觉醒。 唤醒信息可用于鉴定与睡眠觉醒，诊断目的和/或治疗调整相关的睡眠障碍事件。
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公开(公告)号：US20130053705A1
公开(公告)日：2013-02-28
申请号：US13663647
申请日：2012-10-30
Applicant: Cardiac Pacemakers, Inc.
IPC: A61B5/0205 , A61N1/36 , A61B5/08
CPC classification number: A61B5/0205 , A61N1/3601 , A61N1/36521 , A61N1/37211
Abstract: A system comprising implantable device, the implantable medical device including an intrinsic cardiac signal sensor, an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, and a processor coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit. The processor is configured to initiate sampling of a transthoracic voltage signal in a specified time relation to a fiducial marker in a sensed intrinsic cardiac signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal, and determine lung respiration using the sampled transthoracic voltage signal.
Abstract translation: 一种包括可植入装置的系统，所述可植入医疗装置包括固有心脏信号传感器，阻抗测量电路，被配置为将特定电流施加到受试者的经胸部区域，并且对由指定电流产生的经胸电压进行采样， 到内在的心脏信号传感器和阻抗测量电路。 该处理器被配置为开始以感测的本征心脏信号中的基准标记指定的时间关系中的经胸廓电压信号的采样，其中所述采样衰减或去除经胸廓电压信号的心脏搏动体积的变化，并且使用 采样经胸电压信号。
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公开(公告)号：US10702698B2
公开(公告)日：2020-07-07
申请号：US15849989
申请日：2017-12-21
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen B. Ruble , Jason J. Hamann
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
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Patent Agency Ranking
公开(公告)号：US09849290B2
公开(公告)日：2017-12-26
申请号：US15278186
申请日：2016-09-28
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen B. Ruble , Jason J. Hamann
CPC classification number: A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
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公开(公告)号：US20140128953A1
公开(公告)日：2014-05-08
申请号：US14151302
申请日：2014-01-09
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen B. Ruble , Jason J. Hamann
IPC: A61N1/05
CPC classification number: A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
Abstract translation: 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。
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公开(公告)号：US08630707B2
公开(公告)日：2014-01-14
申请号：US13796401
申请日：2013-03-12
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen Ruble , Jason J. Hamann
IPC: A61N1/05
CPC classification number: A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
Abstract translation: 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。
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9.发明申请COORDINATED USE OF RESPIRATORY AND CARDIAC THERAPIES FOR SLEEP DISOREDERED BREATHING 审中-公开协调使用呼吸和心脏治疗用于睡眠呼吸道呼吸公开(公告)号：US20130333696A1
公开(公告)日：2013-12-19
申请号：US14015407
申请日：2013-08-30
Applicant: Cardiac Pacemakers, Inc.
Inventor： Kent Lee , Jesse W. Hartley , Jeffrey E. Stahmann , Quan Ni
CPC classification number: A61M16/00 , A61M16/0009 , A61M16/026 , A61M2205/3523 , A61M2230/00 , A61M2230/60 , A61N1/3601 , A61N1/36514
Abstract: Methods and systems involve coordinating therapies used for treating disordered breathing. Disordered breathing therapies may include cardiac electrical stimulation therapy and external respiratory therapy as well as other therapies for treating disordered breathing in a patient. The therapies delivered to the patient may be coordinated to enhance effectiveness of the therapy, to reduce therapy interactions, to improve patient sleep, or to achieve other therapeutic goals.
Abstract translation: 方法和系统涉及协调用于治疗无序呼吸的治疗。 无序呼吸治疗可能包括心脏电刺激治疗和外部呼吸治疗以及治疗患者无序呼吸的其他疗法。 可以协调递送给患者的治疗以增强治疗的有效性，减少治疗相互作用，改善患者睡眠或实现其他治疗目标。
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公开(公告)号：US08442633B2
公开(公告)日：2013-05-14
申请号：US13663647
申请日：2012-10-30
Applicant: Cardiac Pacemakers, Inc.
IPC: A61N1/365
CPC classification number: A61B5/0205 , A61N1/3601 , A61N1/36521 , A61N1/37211
Abstract: A system comprising implantable device, the implantable medical device including an intrinsic cardiac signal sensor, an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, and a processor coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit. The processor is configured to initiate sampling of a transthoracic voltage signal in a specified time relation to a fiducial marker in a sensed intrinsic cardiac signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal, and determine lung respiration using the sampled transthoracic voltage signal.
Abstract translation: 一种包括可植入装置的系统，所述可植入医疗装置包括固有心脏信号传感器，阻抗测量电路，被配置为将特定电流施加到受试者的经胸部区域，并且对由指定电流产生的经胸电压进行采样， 到内在的心脏信号传感器和阻抗测量电路。 该处理器被配置为开始以感测的本征心脏信号中的基准标记指定的时间关系中的经胸廓电压信号的采样，其中所述采样衰减或去除经胸廓电压信号的心脏搏动体积的变化，并且使用 采样经胸电压信号。
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