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    Systems and methods for avoiding neural stimulation habituation
    2.
    发明授权
    Systems and methods for avoiding neural stimulation habituation 有权

    公开(公告)号：US10799699B2

    公开(公告)日：2020-10-13

    申请号：US15943916

    申请日：2018-04-03

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Imad Libbus ,  Andrew P. Kramer

    IPC: A61N1/36 ,  A61N1/372

    Abstract: An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.

    Neural stimulation system for cardiac fat pads
    5.
    发明授权
    Neural stimulation system for cardiac fat pads 有权

    公开(公告)号：US09339652B2

    公开(公告)日：2016-05-17

    申请号：US14571809

    申请日：2014-12-16

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Julia Moffitt ,  Imad Libbus

    IPC: A61N1/39 ,  A61N1/36 ,  A61N1/05 ,  A61N1/365

    CPC classification number: A61N1/36114 ,  A61N1/0551 ,  A61N1/056 ,  A61N1/0587 ,  A61N1/36135 ,  A61N1/36514 ,  A61N1/3962 ,  A61N1/3987

    Abstract: Various aspects relate to a device which, in various embodiments, comprises a header, a neural stimulator, a detector and a controller. The header includes at least one port to connect to at least one lead, and includes first and second channels for use to provide neural stimulation to first and second neural stimulation sites for a heart. The controller is connected to the detector and the neural stimulator to selectively deliver a therapy based on the feedback signal. A first therapy signal is delivered to the first neural stimulation site to selectively control contractility and a second therapy signal is delivered to the second neural stimulation site to selectively control one of a sinus rate and an AV conduction. Other aspects and embodiments are provided herein.

    VAGAL NERVE STIMULATOR WITH MODE SWITCHING
    7.
    发明申请
    VAGAL NERVE STIMULATOR WITH MODE SWITCHING 审中-公开
    带模式切换的VAGAL神经刺激仪

    公开(公告)号：US20140316487A1

    公开(公告)日：2014-10-23

    申请号：US14318785

    申请日：2014-06-30

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Imad Libbus ,  Andrew P. Kramer ,  William J. Linder ,  Jeffrey E. Stahmann

    IPC: A61N1/36

    CPC classification number: A61N1/36128 ,  A61M5/1723 ,  A61N1/3605 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3688

    Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.

    Abstract translation: 本主题的各个方面涉及可植入装置。 各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗 一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。 响应于触发事件，控制器适于在至少两种模式之间切换。 本文提供了其它方面和实施例。

    UNIDIRECTIONAL NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS
    8.
    发明申请
    UNIDIRECTIONAL NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 审中-公开
    非线性神经刺激系统，设备和方法

    公开(公告)号：US20140243932A1

    公开(公告)日：2014-08-28

    申请号：US14271779

    申请日：2014-05-07

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Imad Libbus ,  Avram Scheiner

    IPC: A61N1/36

    CPC classification number: A61N1/36057 ,  A61B5/021 ,  A61B5/024 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/37217 ,  A61N1/37282 ,  A61N1/37288

    Abstract: An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.

    Abstract translation: 一个实施方案涉及用于递送单向传入神经刺激治疗的方法。 传递测试神经刺激，并监测对测试神经刺激的生理反应。 如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。 如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。 使用至少一个治疗参数递送单向传入神经刺激。

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