公开(公告)号：US11239065B2

公开(公告)日：2022-02-01

申请号：US17106445

申请日：2020-11-30

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574 ,  B01L3/02 ,  G01N1/40

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20200305723A1

公开(公告)日：2020-10-01

申请号：US16882801

申请日：2020-05-26

Applicant: Board of Regents, The University of Texas System

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  Noah Giese ,  Nitesh Katta

IPC: A61B5/00 ,  G01N33/483 ,  H01J49/04 ,  H01J49/16 ,  A61B1/313 ,  A61B17/34 ,  A61B10/02 ,  A61M25/00 ,  A61B34/30

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20220296102A1

公开(公告)日：2022-09-22

申请号：US17453740

申请日：2021-11-05

Applicant: Board of Regents, The University of Texas System

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  Noah Giese ,  Nitesh Katta

IPC: A61B5/00 ,  A61B34/30 ,  A61B1/313 ,  A61B10/02 ,  A61B17/34 ,  A61M25/00 ,  G01N33/483 ,  H01J49/04 ,  H01J49/16

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20180143147A1

公开(公告)日：2018-05-24

申请号：US15571957

申请日：2016-05-11

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas Milner ,  Austin McElroy ,  Joseph Beaman ,  Scott Fish

IPC: G01N23/203 ,  B29C64/153 ,  B22F3/105 ,  B29C64/386 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y99/00

CPC classification number: G01N23/203 ,  B22F3/105 ,  B22F3/1055 ,  B22F2003/1057 ,  B22F2999/00 ,  B29C64/153 ,  B29C64/386 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y99/00 ,  Y02P10/295 ,  B22F2203/03 ,  B22F2202/11

Abstract: An apparatus and method for detecting defects in an additive manufacturing process is provided. An example method may include depositing a first layer of material, depositing a second layer of material in at least partial contact with the first layer of material, and inducing a phase change between the first and second layers of material via an energy beam. Further, the method may include directing an electromagnetic radiation beam to at least a portion of a subsurface interface between the first and second layers, measuring radiation returned from the material, and based on the measured radiation, determining a location of a refractive index gradient within the material.

公开(公告)号：US11737671B2

公开(公告)日：2023-08-29

申请号：US17453740

申请日：2021-11-05

Applicant: Board of Regents, The University of Texas System

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  Noah Giese ,  Nitesh Katta

IPC: A61B5/00 ,  H01J49/04 ,  H01J49/16 ,  A61B34/30 ,  A61B1/313 ,  A61B10/02 ,  A61B17/34 ,  A61M25/00 ,  G01N33/483 ,  A61B90/00 ,  A61B10/06

CPC classification number: A61B5/0075 ,  A61B1/3132 ,  A61B10/02 ,  A61B17/34 ,  A61B34/30 ,  A61M25/0026 ,  G01N33/4833 ,  H01J49/0431 ,  H01J49/165 ,  A61B10/06 ,  A61B2090/395 ,  A61B2090/3983

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US11756778B2

公开(公告)日：2023-09-12

申请号：US17566192

申请日：2021-12-30

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574 ,  B01L3/02 ,  G01N1/40

CPC classification number: H01J49/0431 ,  A61B10/0045 ,  B01L3/502 ,  G01N1/02 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/04 ,  B01L3/0293 ,  B01L2200/0605 ,  B01L2400/0655 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2560/00

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US12087566B2

公开(公告)日：2024-09-10

申请号：US18227417

申请日：2023-07-28

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC: H01J49/04 ,  A61B10/00 ,  B01L3/00 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/68 ,  H01J49/00 ,  B01L3/02 ,  G01N1/02 ,  G01N1/40

CPC classification number: H01J49/0431 ,  A61B10/0045 ,  B01L3/502 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/04 ,  B01L3/0293 ,  B01L2200/0605 ,  B01L2400/0655 ,  G01N1/02 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2560/00

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20220268784A1

公开(公告)日：2022-08-25

申请号：US17457800

申请日：2021-12-06

Applicant: Board of Regents, The University of Texas System

Inventor： Livia Schiavinato Eberlin ,  Michael T. Breen ,  Jialing Zhang ,  Clara L. Feider ,  John Lin ,  Thomas Milner

IPC: G01N33/68 ,  G16H50/20

Abstract: In a general aspect, methods and devices are provided for using mass spectrometry to identify endometriosis. In some aspects, a fixed or discrete volume of a solvent is applied to a tissue site including possible endometriosis tissue. The applied solvent is collected to obtain a liquid sample. The liquid sample is subjected to mass spectrometry analysis. The liquid sample is collected from a tissue site in vivo during a medical procedure. The mass spectrometry data are analyzed to identify whether the tissue site comprises endometriosis.

公开(公告)号：US10943775B2

公开(公告)日：2021-03-09

申请号：US16817728

申请日：2020-03-13

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC: H01J49/00 ,  H01J49/04 ,  B01L3/00 ,  G01N1/02 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/68 ,  A61B10/00 ,  B01L3/02 ,  G01N1/40

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.