Abstract:
This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).
Abstract:
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
Abstract:
FIG. 1 is a front elevational view of an oral cleaning tool showing my new design; FIG. 2 is a rear elevational view thereof; FIG. 3 is a left side view thereof; FIG. 4 is a right side view thereof; FIG. 5 is an enlarged top plan view thereof; FIG. 6 is an enlarged bottom plan view thereof; FIG. 7 is a perspective view thereof; and, FIG. 8 is another perspective view thereof.
Abstract:
A method for managing a power load of a grid includes performing a statistic-based distribution estimation of a composite load model using static and dynamic models with Gibbs sampling; deriving a distribution estimation of load model coefficients; and controlling grid power based on a simulation, a prediction, a stability analysis or a reliability analysis with the load model coefficients.
Abstract:
Data quality of Phasor Measurement Unit (PMU) is receiving increasing attention as it has been identified as one of the limiting factors that affect many wide-area measurement system (WAMS) based applications. In general, existing PMU calibration methods include offline testing and model based approaches. However, in practice, the effectiveness of both is limited due to the very strong assumptions employed. This invention presents a novel framework for online error detection and calibration of PMU measurement using density-based spatial clustering of applications with noise (DBSCAN) based on much relaxed assumptions. With a new problem formulation, the proposed data mining based methodology is applicable across a wide spectrum of practical conditions and one side-product of it is more accurate transmission line parameters for the energy management system (EMS) database and protective relay settings. Case studies are presented to demonstrate the effectiveness of the proposed method.
Abstract:
The invention relates to a compound of formula (I) Wherein R1, R2, R3 and R4 are defined as in the description and in the claims. The said compounds of the invention are preferential agoniste of the Carsonabinocid Receptor 2 and thus useful as medicaments and may be used in treatment of chronic pain, atherosclerosis, ischemic/reperfusion injury and other related diseases.A representative compound of this invention is 6-cyclopropylmethoxy-5-(tetrahydro-pyradine-2-carboxglic acid [1-methyl-1-(5-methyl-(1,2,4]oxadiazol-3-yl)-ethyl)-amide.
Abstract:
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
Abstract:
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.