公开(公告)号：US07994280B2

公开(公告)日：2011-08-09

申请号：US11665537

申请日：2005-10-18

Applicant: Stéphane Varray ,  Oleg Werbitzky ,  Thomas Zeiter

Inventor： Stéphane Varray ,  Oleg Werbitzky ,  Thomas Zeiter

IPC: C07K1/04 ,  C07K1/06 ,  C07K1/08

CPC classification number: C07K1/06 ,  C07K1/04

Abstract: A novel compound of formula I is devised.

Abstract translation: 设计出新颖的式I化合物。

公开(公告)号：US20090292106A1

公开(公告)日：2009-11-26

申请号：US12162562

申请日：2007-01-11

Applicant: Oleg Werbitzky ,  Stéphane Varray ,  Matthieu Giraud ,  Carsten Meininghaus

Inventor： Oleg Werbitzky ,  Stéphane Varray ,  Matthieu Giraud ,  Carsten Meininghaus

IPC: C07K14/605

CPC classification number: C07K14/605

Abstract: A new method of synthesizing GLP-1 peptide is devised.

Abstract translation: 设计合成GLP-1肽的新方法。

公开(公告)号：US08445433B2

公开(公告)日：2013-05-21

申请号：US12162562

申请日：2007-01-11

Applicant: Oleg Werbitzky ,  Stéphane Varray ,  Matthieu Giraud ,  Carsten Meininghaus

Inventor： Oleg Werbitzky ,  Stéphane Varray ,  Matthieu Giraud ,  Carsten Meininghaus

IPC: A61K38/26

CPC classification number: C07K14/605

Abstract: A new method of synthesizing GLP-1 peptide is devised.

公开(公告)号：US07939629B2

公开(公告)日：2011-05-10

申请号：US11665541

申请日：2005-10-19

Applicant: Anne-Sophie Droz ,  Jasmine Schnidrig ,  Nicole Studer ,  Stéphane Varray ,  Corinne Wenger ,  Oleg Werbitzky

Inventor： Anne-Sophie Droz ,  Jasmine Schnidrig ,  Nicole Studer ,  Stéphane Varray ,  Corinne Wenger ,  Oleg Werbitzky

IPC: C07K2/00

CPC classification number: C07K14/815

Abstract: A novel method for synthesizing a Hirulog peptide is devised.

Abstract translation: 设计了一种合成Hirulog肽的新方法。

公开(公告)号：US20110046349A1

公开(公告)日：2011-02-24

申请号：US12836411

申请日：2010-07-14

Applicant: Matthieu Giraud ,  Anne-Sophie Droz ,  Stéphane Varray ,  El Djouhar Rekai ,  Marie-Hèléne Brichard ,  Daniel Latassa ,  Christine Devijver ,  Pascal Gilles ,  Jeanne-Marie Cauvin ,  Fernando Albericio ,  Marta Paradis Bas

Inventor： Matthieu Giraud ,  Anne-Sophie Droz ,  Stéphane Varray ,  El Djouhar Rekai ,  Marie-Hèléne Brichard ,  Daniel Latassa ,  Christine Devijver ,  Pascal Gilles ,  Jeanne-Marie Cauvin ,  Fernando Albericio ,  Marta Paradis Bas

IPC: C07K1/06 ,  C07K2/00

CPC classification number: C07K14/605 ,  C07K14/57563

Abstract: Exenatide, a polypeptide having the 39 amino acid sequence H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser- Lys-Gln-Met-15Glu-Glu-Glu--Ala-Val-20Arg-Leu-Phe- Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser- Gly-35Ala--Pro-Pro-Pro-Ser-NH2, respectively its 44-mer analogue H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser- Lys-Gln-Met-15Glu-Glu-Glu--Ala-Val-20Arg-Leu-Phe- Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser- Gly-35Ala--Pro-Pro-Ser-Lys-40Lys-Lys-Lys-Lys-Lys- NH2 is prepared via a convergent four-fragment synthesis strategy from the fragments comprising the amino acid positions 1-10, 11-21, 22-29 and 30-39, respectively 30-44.

Abstract translation: 艾塞那肽，具有39个氨基酸序列H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser-Lys-Gln-Met-15Glu-Glu-Glu-Ala-Val -20Arg-Leu-Phe-Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser-Gly-35Ala-Pro-Pro-Pro-Ser-NH2分别为其44聚体 H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser-Lys-Gln-Met-15Glu-Glu-Glu-Ala-Val-20Arg-Leu-Phe-Ile-Glu -25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser-Gly-35Ala-Pro-Pro-Ser-Lys-40Lys-Lys-Lys-Lys-Lys-NH2通过收敛的四 - 来自包含氨基酸位置1-10,11-21,22-29和30-39的片段的片段合成策略分别为30-44。