公开(公告)号：US08415340B2

公开(公告)日：2013-04-09

申请号：US12670257

申请日：2008-07-24

Applicant: Upender Velaparthi ,  Peiying Liu ,  Mark D. Wittman ,  David R. Langley

Inventor： Upender Velaparthi ,  Peiying Liu ,  Mark D. Wittman ,  David R. Langley

IPC: A61K31/53 ,  A61K31/535 ,  A61K31/55 ,  A61K31/54 ,  A61K31/554 ,  C07D403/04 ,  C07D279/10 ,  C07D267/02 ,  C07D243/08 ,  C07D417/04 ,  C07D413/04

CPC classification number: C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08 ,  C07D491/08 ,  C07D493/08

Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂。

公开(公告)号：US07879855B2

公开(公告)日：2011-02-01

申请号：US12411724

申请日：2009-03-26

Applicant: Mark D. Wittman ,  Harold Mastalerz ,  Kurt Zimmermann ,  Mark G. Saulnier ,  Upender Velaparthi ,  Dolatrai M. Vyas ,  Guifen Zhang ,  Walter Lewis Johnson ,  David B. Frennesson ,  Xiaopeng Sang ,  Peiying Liu ,  David R. Langley

Inventor： Mark D. Wittman ,  Harold Mastalerz ,  Kurt Zimmermann ,  Mark G. Saulnier ,  Upender Velaparthi ,  Dolatrai M. Vyas ,  Guifen Zhang ,  Walter Lewis Johnson ,  David B. Frennesson ,  Xiaopeng Sang ,  Peiying Liu ,  David R. Langley

IPC: A61K31/53 ,  A61P35/00 ,  C07D487/04 ,  C07D401/14 ,  A61P19/02

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。

公开(公告)号：US20100120770A1

公开(公告)日：2010-05-13

申请号：US12595065

申请日：2008-04-09

Applicant: Anne Marinier ,  Marco Dodier ,  Stephan Roy ,  Kurt Zimmermann ,  Xiaopeng Sang ,  Mark D. Wittman ,  David R. Langley ,  Ramkumar Rajamani

Inventor： Anne Marinier ,  Marco Dodier ,  Stephan Roy ,  Kurt Zimmermann ,  Xiaopeng Sang ,  Mark D. Wittman ,  David R. Langley ,  Ramkumar Rajamani

IPC: A61K31/4545 ,  A61K31/444 ,  A61K31/5377 ,  A61P35/00

CPC classification number: C07D417/14

Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's disease.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I噻唑基化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。

公开(公告)号：US20090239838A1

公开(公告)日：2009-09-24

申请号：US12411724

申请日：2009-03-26

Applicant: Mark D. Wittman ,  Harold Mastalerz ,  Kurt Zimmermann ,  Mark G. Saulnier ,  Upender Velaparthi ,  Dolatrai M. Vyas ,  Guifen Zhang ,  Walter Lewis Johnson ,  David B. Frennesson ,  Xiaopeng Sang ,  Peiying Liu ,  David R. Langley

Inventor： Mark D. Wittman ,  Harold Mastalerz ,  Kurt Zimmermann ,  Mark G. Saulnier ,  Upender Velaparthi ,  Dolatrai M. Vyas ,  Guifen Zhang ,  Walter Lewis Johnson ,  David B. Frennesson ,  Xiaopeng Sang ,  Peiying Liu ,  David R. Langley

IPC: A61K31/53 ,  A61P35/00 ,  A61K31/5377

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。

公开(公告)号：US07081454B2

公开(公告)日：2006-07-25

申请号：US10263448

申请日：2002-10-02

Applicant: Mark D. Wittman ,  Neelakantan Balasubramanian ,  Upender Velaparthi ,  Kurt Zimmermann ,  Mark G. Saulnier ,  Peiying Liu ,  Xiaopeng Sang ,  David B. Frennesson ,  Karen M. Stoffan ,  James G. Tarrant ,  Anne Marinier ,  Stephan Roy

Inventor： Mark D. Wittman ,  Neelakantan Balasubramanian ,  Upender Velaparthi ,  Kurt Zimmermann ,  Mark G. Saulnier ,  Peiying Liu ,  Xiaopeng Sang ,  David B. Frennesson ,  Karen M. Stoffan ,  James G. Tarrant ,  Anne Marinier ,  Stephan Roy

IPC: C07D267/10 ,  C07D413/14 ,  A61K31/553 ,  A66K31/5377

CPC classification number: C07D417/14 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶，从而使其成为抗癌剂。 式I化合物还可用于治疗可通过抑制酪氨酸激酶的治疗的其它疾病。

公开(公告)号：US06362217B1

公开(公告)日：2002-03-26

申请号：US09802264

申请日：2001-03-08

Applicant: John F. Kadow ,  Wendy S. Schwartz ,  Paul M. Scola ,  Qiufen May Xue ,  Mark D. Wittman ,  Mu-Jen Wu

Inventor： John F. Kadow ,  Wendy S. Schwartz ,  Paul M. Scola ,  Qiufen May Xue ,  Mark D. Wittman ,  Mu-Jen Wu

IPC: A61K3135

Abstract: The present invention concerns novel 7-deoxy taxane derivatives their use as antitumor agents, and pharmaceutical formulations.

公开(公告)号：US08198438B2

公开(公告)日：2012-06-12

申请号：US12596058

申请日：2008-04-17

Applicant: Anthony J. Sampognaro ,  Mark D. Wittman

Inventor： Anthony J. Sampognaro ,  Mark D. Wittman

IPC: C07D487/04 ,  A61K31/53 ,  A61K35/00

CPC classification number: C07D487/04

Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anti-cancer agents and for the treatment of Alzheimer's Disease.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使其可用作抗癌剂和用于治疗阿尔茨海默病。

公开(公告)号：US20100113454A1

公开(公告)日：2010-05-06

申请号：US12596058

申请日：2008-04-17

Applicant: Anthony J. Sampognaro ,  Mark D. Wittman

Inventor： Anthony J. Sampognaro ,  Mark D. Wittman

IPC: A61K31/53 ,  A61P25/28

CPC classification number: C07D487/04

Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anti-cancer agents and for the treatment of Alzheimer's Disease.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使其可用作抗癌剂和用于治疗阿尔茨海默病。

公开(公告)号：US07470696B2

公开(公告)日：2008-12-30

申请号：US11625973

申请日：2007-01-23

Applicant: Francis Beaulieu ,  Carl Ouellet ,  Kurt Zimmermann ,  Upender Velaparthi ,  Mark D. Wittman

Inventor： Francis Beaulieu ,  Carl Ouellet ,  Kurt Zimmermann ,  Upender Velaparthi ,  Mark D. Wittman

IPC: A61K31/52 ,  C07D473/32

CPC classification number: C07D471/04 ,  C07D473/32 ,  C07D487/04

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶，从而使其成为抗癌剂。

公开(公告)号：US07232826B2

公开(公告)日：2007-06-19

申请号：US10674098

申请日：2003-09-29

Applicant: Upender Velaparthi ,  Mark D. Wittman

Inventor： Upender Velaparthi ,  Mark D. Wittman

IPC: A61K31/496 ,  C07D401/14

CPC classification number: C07D401/04

Abstract: The present invention provides compounds of Formula I or II that are useful as anti-cancer agents and other diseases that can be treated by inhibiting tyrosine kinase enzymes

Abstract translation: 本发明提供了可用作抗癌剂和可通过抑制酪氨酸激酶的治疗的其它疾病的式I或II的化合物