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1.发明授权Detection of colon or breast cancer by measuring TTK polynucleotide expression 失效通过测量TTK多核苷酸表达检测结肠癌或乳腺癌公开(公告)号：US07501242B2
公开(公告)日：2009-03-10
申请号：US10951389
申请日：2004-09-27
Applicant: Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
Inventor： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
CPC classification number: G01N33/68 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Y207/01037 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/6842 , G01N2500/00
Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
Abstract translation: 本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。 这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。 此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。
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公开(公告)号：US20060089321A1
公开(公告)日：2006-04-27
申请号：US10504487
申请日：2003-02-12
Applicant: Annette Walter , Christoph Reinhard , Anne Jefferson , Blanche-Marie Shamoon
Inventor： Annette Walter , Christoph Reinhard , Anne Jefferson , Blanche-Marie Shamoon
IPC: A61K48/00
CPC classification number: C07K14/4702 , A61K38/00 , C12N15/1136 , C12N2310/11 , C12N2310/12
Abstract: Inhibitors of human Cks1 and human Skp2, including antisense oligonucleotides, methods, and compositions specific for human Cks1 and human Skp2, are provided. Methods of using the compositions for modulating Cks1 expression and Skp2 expression, and for regulating cell growth, particularly tumor cell growth, are also provided.
Abstract translation: 提供人Cks1和人Skp2的抑制剂，包括对人Cks1和人Skp2特异性的反义寡核苷酸，方法和组合物。 还提供了使用组合物调节Cks1表达和Skp2表达以及调节细胞生长，特别是肿瘤细胞生长的方法。
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公开(公告)号：US06809194B1
公开(公告)日：2004-10-26
申请号：US09851670
申请日：2001-05-08
Applicant: Christoph Reinhard , Anne B. Jefferson
Inventor： Christoph Reinhard , Anne B. Jefferson
IPC: C07H2104
CPC classification number: C12N15/1137 , A61K38/00 , C07H21/04 , C12N2310/111 , C12Y207/01037
Abstract: Inhibitors of human Akt3, including antisense oligonucleotides, methods, and compositions specific for human Akt3, are provided. Methods of using the compositions for modulating Akt3 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
Abstract translation: 提供人Akt3的抑制剂，包括反义寡核苷酸，方法和对人Akt3特异的组合物。 还提供了使用组合物调节Akt3表达和调节细胞生长，特别是肿瘤细胞生长的方法。
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4.发明授权Cell transfecting formulations of small interfering RNA related compositions and methods of making and use 有权小干扰RNA相关组合物的细胞转染制剂及制备和使用方法公开(公告)号：US08772255B2
公开(公告)日：2014-07-08
申请号：US12053486
申请日：2008-03-21
Applicant: Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
Inventor： Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
IPC: C12N15/113 , A61K47/48
CPC classification number: A61K47/44 , A61K31/7088 , A61K47/6909 , A61K48/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12Y207/01037 , C12N2310/3521
Abstract: Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
Abstract translation: 包含小干扰核糖核酸（siRNA）和某些基于脂质偶联的聚酰胺化合物的递送载体的组合物，其特别可用于递送siRNA和其它多核苷酸至细胞。 而且，制备和使用组合物的方法。
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5.发明授权Device and method for detecting reflected and/or emitted light of an object 有权用于检测物体的反射和/或发射光的装置和方法公开(公告)号：US08472025B2
公开(公告)日：2013-06-25
申请号：US13144072
申请日：2009-12-04
Applicant: Christoph Reinhard , Reto Schletti
Inventor： Christoph Reinhard , Reto Schletti
IPC: G01N21/55
CPC classification number: G07D7/121
Abstract: A device and a method for detecting reflected and/or emitted light of an object (1) are proposed having at least one illumination device (2) illuminating the object (1) with pulsed light, and having at least one sensor (4, 6) capturing the light reflected and/or emitted by the object (1), and having a transport device transporting the object relative to the illumination device (2) and past the sensor 4, 6) in the direction of transport, and having a power supply (16, 17, 18, 19, 20, 21, 22) for the illumination device (2) providing the illumination device (2) with a current that is a periodic function over time, wherein a period comprises at least two current pulses (23, 24) of different magnitudes.
Abstract translation: 提出了一种用于检测物体（1）的反射和/或发射光的装置和方法，其具有至少一个用脉冲光照射物体（1）的照明装置（2），并且具有至少一个传感器（4,6） ）捕获由物体（1）反射和/或发射的光，并且具有相对于照明装置（2）传送物体并经过传感器4,6的传送装置沿传送方向传送，并具有电力 为照明装置（2）提供具有随时间变化的周期性功能的电流（16,17,18,19,20,21,22），其中周期包括至少两个电流脉冲 （23,24）不同程度。
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Patent Agency Ranking
公开(公告)号：US07855058B2
公开(公告)日：2010-12-21
申请号：US11759726
申请日：2007-06-07
Applicant: Christoph Reinhard
Inventor： Christoph Reinhard
CPC classification number: C12N9/1205 , C07K2319/00
Abstract: A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
Abstract translation: 编码称为hPNQALRE的新型细胞周期蛋白依赖性激酶及其表达产物的人基因可用于提供检测肿瘤的试剂和方法。 还提供了治疗增殖性疾病和瘤形成的组合物和方法。
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公开(公告)号：US07700359B2
公开(公告)日：2010-04-20
申请号：US10948737
申请日：2004-09-22
Applicant: Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
Inventor： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
CPC classification number: C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
Abstract translation: 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
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公开(公告)号：US07605246B2
公开(公告)日：2009-10-20
申请号：US09758575
申请日：2001-01-09
Applicant: Joerg Kaufmann , Greg Harrowe , Christoph Reinhard , Sanmao Kang
Inventor： Joerg Kaufmann , Greg Harrowe , Christoph Reinhard , Sanmao Kang
CPC classification number: C07K14/47 , C07K16/18 , C07K2319/00
Abstract: A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.
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9.发明申请CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA RELATED COMPOSITIONS AND METHODS OF MAKING AND USE 有权小干扰RNA相关组合物的细胞转染制剂及其制备和使用方法公开(公告)号：US20090143322A1
公开(公告)日：2009-06-04
申请号：US12053486
申请日：2008-03-21
Applicant: Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
Inventor： Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
CPC classification number: A61K47/44 , A61K31/7088 , A61K47/6909 , A61K48/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12Y207/01037 , C12N2310/3521
Abstract: Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
Abstract translation: 包含小干扰核糖核酸（siRNA）和某些基于脂质偶联的聚酰胺化合物的递送载体的组合物，其特别可用于递送siRNA和其它多核苷酸至细胞。 而且，制备和使用组合物的方法。
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10.发明授权Determining prognosis of colon or breast cancer by measuring TTK expression 失效通过测量TTK表达来确定结肠癌或乳腺癌的预后公开(公告)号：US07501244B2
公开(公告)日：2009-03-10
申请号：US10951477
申请日：2004-09-27
Applicant: Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
Inventor： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
CPC classification number: G01N33/6842 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N2500/00
Abstract: The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
Abstract translation: 本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。 这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。 此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。
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