Thread switching prevents pipeline stalls when executing multiple threads. An analysis of a first thread identifies instructions capable of causing pipeline stalls. If pipeline stalls from the identified instructions are likely, thread switching instructions are added to the first thread in place of the identified instructions. Thread switching instructions direct a microprocessor to suspend executing the thread and begin executing a second thread. Thread switching instructions can be added to the second thread to enable the resumption of the first thread at the location specified by the identified instruction. The thread switching instructions are configured to avoid pipeline stalls when switching threads. Thread switching instructions can store and retrieve thread-specific information upon the suspension and resumption of threads. Thread switching instructions can schedule the execution of two or more threads in accordance with load balancing schemes. Threads can be modified using static or dynamic code analysis and modification techniques.