The invention relates to an integrated installation method for an integral skid-mounted cold box. The method comprises the steps that the foundation in the area affected by the hoisting of the cold box is tamped and leveled, the foundation of the cold box is ground, and a backing plate is arranged; hoisting equipment is in place, the cold box enters the area to be unloaded, and a pump box pipelineis prefabricated; cold box accessories are assembled, and a pump box is assembled in a semi-modularized manner; the cold box is hoisted in place, adjusted and checked, and a base is grouted; a scaffold in the cold box is erected, a bridge cold box is installed, and the pump box and an expansion case are in place; a temporary fixing support is removed, the cold box accessories are installed, and the pump box and an expansion box pipeline are installed; a distributor is adjusted, and the bottom of the cold box is poured with pearlite concrete; process inspection and pipeline pressure test are carried out; the pipeline is swept and the bare cooling is debugged; the scaffold is removed, and a cold insulation plate is installed; and the cold box is filled with the pearlite. According to the integrated installation method, the installation safety and efficiency of the integral skid-mounted cold box can be improved.