The invention relates to an oral fast-dissolving film of a xanthophylls-loaded albumin nanoparticle and a preparation method thereof. The preparation method comprises the following steps: preparing the xanthophylls-loaded albumin nanoparticle from xanthophyll by using an anti-solvent precipitation method and then preparing the oral fast-dissolving film of the xanthophylls-loaded albumin nanoparticle by using a solvent casting method. The film prepared in the invention has an intact surface, no bubble, a uniform color and consistent thickness; drug distribution is uniform; and compared with a xanthophyll bulk drug and an oral fast-dissolving film prepared from the xanthophyll bulk drug, the oral fast-dissolving film prepared in the invention is substantially increased in in-vitro release and in-vivo absorption speeds and degrees and obviously improved in bioavailability.