The present invention relates to the technical field of health-care food and discloses potentilla anserina blood supplementing granules and a preparation method thereof. The potentilla anserina blood supplementing granules comprise the following raw materials in parts by weight: 40-60 parts of potentilla anserina, 10-20 parts of red dates, 10-15 parts of red beans, 5-10 parts of longans, 5-10 parts of Chinese wolfberry fruits, 5-10 parts of brown sugar, 1-5 parts of xanthan gums and 0.3-1 part of citric acid. The potentilla anserine is used as a main material, the red dates, red beans, Chinese wolfberry fruits, longans and brown sugar are used as accessory materials, firstly, an ultrasonic wave-bubble-ozone combined washing device is used to conduct washing to remove dirt adhere to the surfaces of the raw materials, then the washed raw materials are successively subjected to aging, the aged raw materials are crushed, and the crushed raw materials are granulated to obtain the potentilla anserina blood supplementing granules suitable for females to eat. The prepared potentilla anserina blood supplementing granules maintain nutritional values and health-care functions of the potentilla anserina, and also have functions of supplementing blood and calcium, reducing fats and weight, enhancing body health and regulating body immunity. In addition, the potentilla anserina blood supplementing granules are rich in raw materials, simple in technology, easy in operation, low in costs, and suitable for home workshops and an industrial scale production.