US10378069B2
The invention is directed to compositions, kits, and methods for amplifying and detecting a Zika virus nucleic acid sequence in a sample, which comprises a variety of combinations of forward oligonucleotide primers, reverse oligonucleotide primers, and oligonucleotide probes.
US10378068B2
Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment that does not include a Trk inhibitor, methods of determining the likelihood that a subject having a cancer will have a positive response to a treatment with a Trk inhibitor, methods of predicting the efficacy of a Trk inhibitor in a subject having cancer, methods of determining a subject's risk for developing a Trk inhibitor-resistant cancer, and methods of determining the presence of a Trk inhibitor-resistant cancer in a subject, based on the detection of a cell from a sample from the subject that has at least one of the point mutations in NTRK1 and/or NTRK2 and/or NTRK3.
US10378067B2
The present invention provides a primer set and a kit containing same for analyzing a sequence of an MLH1 DNA, an MLH1 mRNA, and/or a cDNA sequence derived from said MLH1 mRNA of a subject to identify a V384 alteration of an MLH1 gene encoded protein.
US10378057B2
The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.
US10378056B2
The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more single nucleotide polymorphism associated with increased risk of altered effectiveness of beta blocker therapy.
US10378047B2
Provided is a method for analyzing the prognosis of cervical cancer according to the human papillomavirus (HPV) DNA integration pattern. The method of analyzing the prognosis of cervical cancer according to the human papillomavirus DNA integration pattern of the present invention enables an observation of the HPV DNA integration pattern with accuracy and convenience via in situ hybridization (ISH) compared to qPCR analysis. Since the prognosis of cervical cancer having the tumors with an episomal pattern and an integrated pattern can be significantly distinguished when the HPV DNA integration patterns are classified by the above method, the survival rate after radiotherapy of cervical cancer, and in particular invasive cervical cancer, can be more accurately analyzed.
US10378045B2
A disposable cartridge for preparing a nucleic acid sample including a stationary cartridge body and a cylindrical rotor rotationally mounted to the cartridge body. The cartridge body includes: (i) a cylindrical surface defining a fixed port and (ii) a syringe barrel defining a bore in fluid communication with the fixed port. When the disposable cartridge is disposed in combination with an assay system, syringe barrel is configured to receive a moveable plunger, i.e., to stroke the plunger into and out of the barrel. The rotor is seated within a cavity of the cartridge body such that a mating surface thereof slideably engages a cylindrical surface of the cavity. The rotor comprises a plurality of chambers fluidly connecting to a plurality of ports along the mating surface at different radial positions such that at least one of the chambers is fluidly connected to one of the ports by a connecting channel. Rotation of the rotor aligns one of the rotor ports with the fixed port such that fluid may be moved into and out of the chambers in response to axial displacement of the moveable plunger.
US10378042B2
An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection medium downstream from the moisture exchange device and configured to collect the bioparticles. The method includes delivering bioparticles in a gas stream, humidifying or dehumidifying the bioparticles in the gas stream by transport of water across a partition member and into a vapor phase of the gas stream, and collecting the bioparticles by a collection medium.
US10378041B2
A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
US10378040B2
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
US10378035B2
Methods of in vitro transcription using cyanophage Syn5 RNA polymerase (RNAP) or mutants thereof and transcription conditions are provided.
US10378034B2
The present invention provides to methods for the production of neuraminic acid or derivatives thereof under alkaline conditions and to the use of neuraminate lyases showing improved characteristics under alkaline conditions in the production of neuraminic acid or its derivatives. More particularly, the present invention employs inter alia a N-acetylneuraminate lyase which has been isolated from the psychrophilic bacterium Aliivibrio salmonicida LFI1238 and has shown to have improved characteristics under alkaline conditions.
US10378029B2
A method produces a chemical product by continuous fermentation including filtering a culture liquid of a microorganism(s) through a separation membrane, retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid, adding a fermentation feedstock to the culture liquid, and recovering a product in the filtrate, wherein the microorganism(s) is/are a microorganism(s) that undergo(es) catabolite repression, and the fermentation feedstock comprises hexose and pentose.
US10378022B2
The present invention includes a seed, a plant, a protoplast, a hybrid and methods of making the same of a cotton cultivar recombinantly modified overexpresses at least one of AtRAV1, AtRAV2 to confer longer fibers to transgenic cotton plants under drought conditions without an effect on yield.
US10378019B2
Methods of pre-methylation of foreign DNA to improve genetic transformation in cyanobacterium. Two Type II methyltransferase-encoding genes, i.e., M (sll0729) and C (slr0214), were cloned from the chromosome of Synechocystis sp. PCC 6803 (hereafter Synechocystis 6803) and expressed in E. coli that harbors the integrative plasmid pBS-SPtK or pJU105. After pre-methylation in E. coli, the integrative plasmids were extracted and used for transformation of Synechocystis 6803. The results showed that expression of slr0214 in the integrative-plasmid-harboring E. coli cells before DNA preparation resulted in orders of magnitude higher efficiency in the following integrative transformation of Synechocystis 6803.
US10378011B2
An oligonucleotide having improved affinity for AGO2 is disclosed. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) wherein X1 is an oxygen atom or the like, R1 is formula (IIA), wherein R5A is halogen or the like, and R6A is a hydrogen atom or the like, or formula (IVA) wherein Y3A is a nitrogen atom or the like, and Y4A is CH or the like, or the like, R2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and R3 is a hydrogen atom or the like at the 5′ end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. A method for improving the knockdown activity of an oligonucleotide wherein the oligonucleotide has a knockdown activity against an mRNA encoding a protein involved in a disease.
US10378009B2
Aspects of the invention include methods and compositions for microbial enhanced oil recovery (MEOR). In particular, the invention focuses on new, efficient, economical and environmentally safe microbial methods to enhance oil recovery in existing oil reservoirs, as well as microorganisms useful in such methods.
US10378004B2
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.
US10377999B2
The present invention relates to mixtures comprising a polypeptide or a plurality of polypeptides having biomass-degrading activity that is solubilized from an inclusion body, and retaining biomass-degrading activity, and methods for producing and using the same. The invention described herein provides methods for increasing the yield of recombinant protein with biomass-degrading activity that can be isolated from host cells.
US10377991B2
This invention provides a method for stably producing airway epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing airway epithelial cells from pluripotent stem cells comprising steps: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3β inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGFβ inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3β inhibitor; (5) subjecting the cells obtained after Step (3) to three-dimensional culture in a medium containing a GSK3β inhibitor, FGF10, and a ROCK inhibitor; and (6) subjecting the proximal airway epithelial progenitor cells obtained in Step (5) to three-dimensional culture in a medium containing a ROCK inhibitor.
US10377983B2
The invention relates to methods of producing a diatom biomass. More particularly, the invention relates to methods to produce a diatom biomass using a continuous culture to produce a volumetric production rate of biomass of at least 20 g dry weight/L/day, wherein the culture medium is designed to provide the essential nutrients to maintain the diatom in log phase growth. In a preferred cmbodimcnt the biomass comprises highly unsaturated fatty acid.
US10377974B2
A hand dishwashing detergent composition having a surfactant system a lipase at least 0.05% by weight of the composition of at least one monovalent, divalent or trivalent cation or a mixture thereof.
US10377971B2
Detergent compositions effective for controlling hard water scale accumulation are disclosed. Detergent compositions employing phosphinosuccinic acid and mono-, bis- and oligomeric phosphinosuccinic acid (PSO) derivatives with alkali metal carbonate and/or alkali metal hydroxide reduce had water scale accumulation on treated surfaces at alkaline conditions between about pH of 9 and 12.5. Methods employing the detergent compositions and preventing hard water scale accumulation are also provided.
US10377966B2
A composition including a plurality of particles, the particles including about 25% to about 94% by weight a water soluble carrier; about 5% to about 45% by weight a quaternary ammonium compound; about 1% to about 40% by weight a fatty acid; and about 0.5% to about 10% by weight a cationic polymer; wherein each of the particles has a mass from about 1 mg to about 1 g.
US10377965B2
The present invention relates to a delivery system based on photosensitive acetal or ketal compounds capable of liberating upon exposure to light an active volatile carbonyl compound in a controlled manner from a surface into the surrounding. The delivery system can be used to release active substances such as flavors, fragrances, malodor counteractants, insect attractants or insect repellents. The invention also relates to the use of said acetal or ketal compounds in perfumery, as well as in perfuming compositions or perfumed consumer articles.
US10377964B2
The invention provides a magneto-rheological grease composition which contains (a) a base oil including at least 30% by mass of an ether type synthetic oil; (b) an aliphatic diurea thickener; and (c) magnetic particles in an amount of 45 to 95% by mass based on the total mass of the composition. The magneto-rheological grease composition can show superior thermal stability, dispersion stability and magneto-rheological properties.
US10377961B2
A lubricating oil including a lubricating oil base stock as a major component; and a mixture of (i) one or more protected lubricating oil additives having a first performance function, and (ii) one or more unprotected lubricating oil additives having a second performance function, as a minor component. The first performance function and the second performance function are the same. The one or more protected lubricating oil additives are inactive with respect to their performance function. The one or more protected lubricating oil additives are converted into one or more unprotected lubricating oil additives in the lubricating oil in-service in an engine or other mechanical component. A method for controlled release of one or more lubricating oil additives into a lubricating oil. A method for improving oxidative stability of a lubricating oil and extending performance life of one or more lubricating oil additives.
US10377959B2
Unleaded aviation gasoline. An unleaded aviation gasoline includes a blend of high octane alkylate, an effective amount of selected alkyl benzenes, and selected aromatic amines sufficient to improve the functional engine performance to avoid harmful detonation sufficient to meet or exceed selected standards for detonation performance requirements in full scale aircraft piston spark ignition engines designed for use with Grade 100LL avgas. Suitable alkylated benzenes may include a mixture of xylene isomers. Selected aromatic amines, such as N-methyl-p-toluidine, are used to increase performance. The high octane alkylate may be an aviation alkylate, or iso-octane, or both, and may utilize high octane alkylates having a motor octane number of between about ninety-seven (97) and about one hundred (100). Suitable amounts of iso-pentane, n-butane, and iso-butane may be used for providing vapor pressure in a commercially acceptable range.
US10377955B2
The present invention describes a device for controlling cooling of a heat transfer solid supplying or withdrawing heat to or from a unit carrying out globally endothermic or exothermic reactions respectively. The exchange bundle of said device is in a triangular pattern.
US10377953B2
The present disclosure relates to processes and systems that convert biomass to stable intermediate hydrocarbon products that having a greatly decreased oxygen content. This stabilized intermediate hydrocarbon product may be easily be stored for an extended period of time, further refined into liquid transportation fuels (either alone or mixed with petroleum-derived hydrocarbons), or blended with petroleum-derived blendstocks to produce a finished liquid transportation fuel.
US10377948B2
An etching composition selectively removes a titanium nitride film from a stacked conductive film structure including a titanium nitride (TiN) film and a tantalum nitride (TaN) film. The etching composition configured to etch titanium nitride (TiN) includes 5 wt % to 30 wt % of hydrogen peroxide, 15 wt % to 50 wt % of acid compound, and 0.001 wt % to 5 wt % of corrosion inhibitor, with respect to a total weight of the etching composition, wherein the acid compound includes at least one of phosphoric acid (H3PO4), nitric acid (HNO3), hydrochloric acid (HCl), hydroiodic acid (HI), hydrobromic acid (HBr), perchloric acid (HNO4), silicic acid (H2SiO3), boric acid (H3BO3), acetic acid (CH3COOH), propionic acid (C2H5COOH), lactic acid (CH3CH(OH)COOH), and glycolic acid (HOCH2COOH).
US10377945B2
Mixed halide scintillation materials of the general formula AB(1-y)MyX′wX″(3-w), where 0≤y≤1, 0.05≤w≤1, A may be an alkali metal, B may be an alkali earth metal, and X′ and X″ may be two different halogen atoms, and of the general formula A(1-y)BMyX′wX″(3-w), where 0≤y≤1, 0.05≤w≤1, A maybe an alkali metal, B may be an alkali earth metal, and X′ and X″ are two different halogen atoms. The scintillation materials of formula (1) include a divalent external activator, M, such as Eu2+ or Yb2+. The scintillation materials of formula (2) include a monovalent external activator, M, such as Tl+, Na+ and In+.
US10377943B2
Disclosed is a redox-complementary electrochromic device exhibiting black-to-transmissive switching, wherein the device comprises an electrochromic layer and a redox-active material layer sandwiched between a transparent first electrode and a transparent secondary electrode, the electrochromic layer comprising an electrochromic Co-based metallo-supramolecular polymer represented by the formula (I), and the redox active material being capable of reacting with the electrochromic material to change the electrochromic material from black state into colorless transmissive state, where in the formula (I), X represents a counter anion, R represents a single bond or a spacer comprising a carbon atom and a hydrogen atom, each of R1 to R4 independently represents a hydrogen atom or a substituent group, and n represents an integer of from 2 to 5000, which indicates a degree of polymerization.
US10377935B2
The use of an alcoholic compound to improve the miscibility of ammonia with 2,3,3,3-tetrafluoropropene, as well as to compositions of ammonia, 2,3,3,3-tetrafluoropropene and an alcoholic compound, and the use thereof, in particular in heat-transfer applications. A composition including 2,3,3,3-tetrafluoropropene, ammonia and an alcoholic compound having a melting point less than or equal to 0° C.
US10377930B2
A polyurethane glass sealant is made by reacting a poly(1,2-butylene oxide) polymer with a chain extender and a polyisocyanate. The poly(1,2-butylene oxide) polymer may be used as a mixture with up to 50% by weight of other polyols, including castor oil. The sealant is especially useful as a secondary sealant for an insulated glass unit (IGU).
US10377915B2
A treated monomer for optical fiber coatings, a coating composition containing the treated monomer, a coating formed from a coating composition containing a treated monomer, and a fiber coated with the coating formed from a coating composition containing a treated monomer. The monomer is an alkoxylated alkyl acrylate and is formed by acrylating a polyol precursor. The monomer may include residual unreacted polyol precursor. The monomer is treated with a derivatizing agent to convert residual unreacted polyol to a derivative form. The derivative form is less susceptible to degradation to the corresponding non-alkoxylated alcohol or other lower alkoxylated alcohol. The treated monomer includes the alkoxylated alkyl acrylate and the derivative form of the polyol.
US10377914B2
The present invention relates to a method of producing emulsion polymer particles having a core-shell structure wherein at least one polyalkylene oxide containing additive is used in the core, and also to their use in paints, paper coatings, foams, crop protection agents, liquid inks and cosmetic compositions.
US10377906B2
The invention relates to a rheology control agent containing i) 15-95% by weight of an amide compound (A), ii) 5-75% by weight of a urea compound (B), iii) 0-50% by weight of an ionogenic compound (C) and iv) 0-35% weight of an organic solvent (D).
US10377897B2
The invention relates to a laser-markable polyamide composition comprising: a first phase comprising Sb2O3 and an aliphatic polyamide with an amide density AD1, and a second phase comprising an aliphatic polyamide with an amide density AD2, wherein AD1-AD2 is at least 0.01, and wherein the amount of Sb2O3 is between 0.1 and 5 wt %, a halogen-free flame retardant in an amount of between 1 to 25 wt %, wherein the amount in weight percentage are based on the total amount of composition. The invention also relates to a process for preparing a laser-markable polyamide composition, as well as laser-marked products comprising the composition.
US10377895B2
The present invention relates to a conductive polymer material of poly(thio- or seleno-)phene type containing at least two distinct species of counteranion, including a first species which is an anionic form of sulphuric acid, and a second species of counteranion selected from triflate, triflimidate, tosylate, mesylate, perchlorate and hexafluorophosphate. The invention also relates to a process for preparing such a material and the use thereof as conductive film. The invention also targets a substrate coated at least partly by a film of a material as defined above, a device comprising a material as defined above as conductive material, and also the use thereof in the organic electronics, organic thermoelectricity, organic photovoltaic and organic photodetector fields.
US10377891B2
Resin compositions, layers, and interlayers comprising two or more poly(vinyl acetal) resins and at least one blending agent or haze reducing agent are provided. Such compositions, layers, and interlayers exhibit enhanced optical properties while retaining other properties, such as impact resistance and acoustic performance.
US10377886B2
A polyethylene for a pipe and a joint of the present invention satisfies the following characteristics (1) to (5): Characteristic (1): a melt flow rate at a temperature of 190° C. and a load of 21.6 kg (HLMFR) is 5 to 20 g/10 minutes, Characteristic (2): a density (D) is 0.954 to 0.960 g/cm3, Characteristic (3): a ratio of weight-average molecular weight (Mw) and number-average molecular weight (Mn) (Mw/Mn) measured by gel permeation chromatography (GPC) is 15 to 27, Characteristic (4): a rupture time at 80° C. and 5 MPa by a full notch creep test (FNCT) is 150 hours or more, and Characteristic (5): a Charpy impact strength (CIS) measured at −20° C. is 8.5 kJ/m2 or more.
US10377883B2
The present invention provides a rubber composition for a tire having improved workability and abrasion resistance. A rubber composition for a tire according to the present invention comprises: a polybutadiene which has: (A) a Mooney viscosity (ML1+4,100° C.) being 43 or more; (B) a ratio (Tcp/ML1+4,100° C.) of 5 wt % toluene solution viscosity (Tcp) to Mooney viscosity (ML1+4,100° C.) being 0.9 to 2.3; (C) a stress relaxation time (T80) being 10.0 to 40.0 seconds, which is a time until a torque is attenuated by 80% when the torque at the end of ML1+4,100° C. measurement is 100%; and (D) a molecular weight distribution (Mw/Mn) being 2.50 to 4.00; another rubber (ii); and a rubber reinforcing material (iii).
US10377879B2
A self-strengthening material is provided, the material comprising a polymer matrix having a plurality of chemical amplifiers dispersed throughout the polymer matrix and a plurality of triggerable reservoirs, the triggerable reservoirs capable of releasing at least one activator of the plurality of chemical amplifiers, wherein the plurality of chemical amplifiers reacts with the at least one activator to produce additional activators capable of changing the mechanical properties of the polymer matrix, and thus strengthening the material.
US10377873B2
Provided are an expanded acrylic resin beads molded article that produces little soot during burning, and has good castabilities and high strength, and an expandable acrylic resin bead and an expanded acrylic resin bead for producing the expanded acrylic resin beads molded article. The expandable acrylic resin bead includes a physical blowing agent and a copolymer. The copolymer is composed of a methyl methacrylate component, an acrylic acid ester component, and a styrene component in a predetermined proportion. The copolymer constitutes a base resin of the expandable acrylic resin beads. The water content of the expandable acrylic resin bead is a 0.5 mass % or less. The expanded acrylic resin bead includes the copolymer and has a bulk density and cell diameters within predetermined ranges, and the expanded acrylic resin beads molded article is produced by in-mold molding of plural expanded beads.
US10377870B2
The present invention is a long gas barrier laminate including a base, a functional layer, a smoothing layer, and a gas barrier layer, the functional layer being stacked on one side of the base, the smoothing layer and the gas barrier layer being sequentially stacked on the other side of the base, and a coefficient of static friction between a surface of the functional layer that is situated opposite to the base and a surface of the gas barrier layer that is situated opposite to the base being 0.35 to 0.80; and a method for producing the long gas barrier laminate.
US10377857B2
The present invention relates to thermoplastic polyamides (PA) comprising recurring units derived from a PFPE dicarboxylic acid (PFPA-DA) or a PFPE diamine (PFPE-NN) in a defined weight amount with respect to other units derived from the other monomers used in the course of polymerization. Polyamides (PA) are endowed with improved surface properties, chemical resistance and reduced brittleness and do not require the addiction of impact modifiers.
US10377851B2
A resin does not need to incorporate a fluorescent substance and exhibits fluorescence itself. Also, a liquid crystal polymer is provided which does not contain a bleeding out substance such as hydrophobic silica and barium sulfate and which has an effect of suppressing fibrillation in the resin itself. A liquid crystal polymer includes a copolymer of a polymerizable monomer (A) selected from the group consisting of pyromellitic acid or anhydride thereof and a reactive derivative thereof and a polymerizable monomer (B).
US10377847B2
The present invention relates to improved hydrogel materials using water gellants that are comprised of polymer backbones P to which hydrogen bonding 4H-units are covalently attached via a hydrophobic linker L. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and function and are especially suitable for biomedical applications.
US10377839B2
Solid adducts comprising MgCl2, ethanol and water characterized in that the amount of ethanol ranges from 50% to less than 57% by weight, the amount of water is ranges from 0.5 to 5% by weight, the ethanol/water weight ratio is lower than 60 and the porosity determined with Hg method due to pores with radius up to 1 μm and expressed in cm3/g, is lower than 0.2.
US10377831B2
The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab
US10377826B2
Antigen binding constructs that bind to CD8, for example antibodies, including antibody fragments (such as scFv, minibodies, and cys-diabodies) that bind to CD8, are described herein. Methods of use are described herein.
US10377824B2
The present invention provides isolated monoclonal antibodies that specifically bind LAG-3, and have optimized functional properties compared to previously described anti-LAG-3 antibodies, such as antibody 25F7 (US 2011/0150892 A1). These properties include reduced deamidation sites, while still retaining high affinity binding to human LAG-3, and physical (i.e., thermal and chemical) stability. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided, as well as immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies. The present invention also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody of the invention. Combination therapy, in which the antibodies are co-administered with at least one additional immunostimulatory antibody, is also provided.
US10377820B2
The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
US10377819B2
The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGFβ).
US10377818B2
Methods of treating glioma are provided. Aspects of the invention include administering a therapeutically-effective amount of an agent that inhibits the activity of one or more neuronal activity-regulated proteins selected from: neuroligin-3, brain-derived neurotrophic factor (BDNF), or brevican, to a patient with a glioma. In certain embodiments, the subject methods involve treating a neurological dysfunction, reducing invasion of a glioma cell into brain tissue, and/or reducing the growth rate of a glioma in the patient. Also provided herein are methods for identifying an agent that modulates the mitotic index of a glial cell, and methods for stimulating the proliferation of a glial cell. Kits that find use in practicing the subject methods are also provided.
US10377792B2
This invention is in the field of micro-organism and algal cell processing. The invention relates to a method of maximizing migration of micro-organism and/or algal cells to a solvent fraction while simultaneously displacing water in a separate fraction and subsequent extraction of hydrophobic products from the organisms. The invention further relates to a method of sequestration of protein from an aqueous phase to an organic solvent.
US10377786B2
A green route for preparing a metal organic framework include mixing metal precursor with a ligand precursor to form a solvent-free mixture; adding droplets of water to the mixture; heating the mixture at a first temperature after adding the water; and isolating the metal organic framework material including the metal and the ligand.
US10377780B2
The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
US10377779B2
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.
US10377778B2
The present invention relates complexes comprising a PSMA targeting compound linked to a radionuclide, such as 212Pb or 227Th. These compounds, and pharmaceutical compositions comprising them, can be used for medical applications. These applications include the treatment of prostate cancer, and the complexes allow for dual targeting of cancers.
US10377775B2
A method simply produces a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end without using a heavy metal catalyst. A method for producing a polyalkylene glycol derivative having an amino group at the end by reacting a compound represented by the general formula (V) with an alkylene oxide, then reacting a reaction product with an electrophile represented by the general formula (I), and deprotecting the obtained product without using a heavy metal: RA3O(RA4O)k-1RA4O−M+ (V) wherein RA3 represents a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms; RA4 represents an alkylene group having 2 to 8 carbon atoms; k represents an integer of 2 to 5; and M represents an alkali metal; wherein RA1a and RA1b each independently represent a protective group of the amino group, or one of RA1a and RA1b represents H and the other represents a protective group of the amino group, or RA1a and RA1b bind to each other to form a cyclic protective group, and the protective group is deprotectable without using a heavy metal; RA2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; and X represents a leaving group.
US10377773B2
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.
US10377761B2
Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.
US10377758B2
The present invention relates to co-crystals of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
US10377754B2
An object of the present invention is to develop and provide a novel agricultural and horticultural insecticide in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like.Provided is a hydrazonyl group-containing condensed heterocyclic compound or a salt thereof, preferably a condensed heterocyclic compound represented by the general formula (1): {wherein R1 represents, for example, an alkyl group, R2 represents, for example, a hydrogen atom, R3 and R4 each represent, for example, an alkyl group, a haloalkyl group or an acyl group, A1 represents, for example, a nitrogen atom, A2 represents, for example, N-Me or an oxygen atom, A3 represents, for example, a carbon atom or a nitrogen atom, A4 represents, for example, C—H, m represents, for example, 2, and n represents, for example, 1}, or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.
US10377752B2
A process of synthesizing 2-bromo-LSD or a salt or hydrate thereof comprising the steps of reacting methylergometrine with a brominating agent to produce [(1S)-1-(Hydroxymethyl)propylamino][(6aR,9R)-5-bromo-7-methyl-4,7-diaza-4,6,6a,7,8,9-hexahydroacephenanthrylen-9-yl]formaldehyde as a first intermediate, and then hydrolyzing [(1S)-1-(Hydroxymethyl)propylamino][(6aR,9R)-5-bromo-7-methyl-4,7-diaza-4,6,6a,7,8,9-hexahydroacephenanthrylen-9-yl]formaldehyde to yield bromo-lysergic acid as a second intermediate, wherein bromo-lysergic acid is then amidated to yield 2-bromo-LSD or a salt or hydrate thereof.
US10377750B2
The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treatment of neurodegenerative diseases and disorders, such as Alzheimer's disease.
US10377749B2
The present invention addresses the problem of providing a purification method for a 5-(thiazol-4-yl)indolin-2-one derivative that is useful as a medication. The present invention provides a purification method for a compound represented by formula (1) (in the formula, each n is independently 2, 3, 4, 5, or 6, R1 and R2 are identical or different and each independently represent a C1-6 alkyl group, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 each represent a hydrogen atom, a C1-6 alkyl group, an aryl group, or a heteroaryl group), or a geometric isomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. The purification method includes a purification step performed using a solid-phase support adsorbent in the presence of a purification solvent.
US10377741B2
Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
US10377740B2
The present specification provides a heterocyclic compound and an organic light emitting device including the same.
US10377732B2
The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).
US10377731B2
The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
US10377723B2
A solid-supported catalyst ligand which chelates palladium (II) species to form a complex that functions as a heterogeneous catalyst that is stable and can be recycled without significantly losing any catalytic activity in a variety of chemical transformations, a method for producing the solid-supported catalyst ligand and a method for catalyzing a palladium cross-coupling reaction, such as the Suzuki-Miyaura, Mizoroki-Heck, and Sonagashira reactions.
US10377721B2
Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.
US10377719B2
The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
US10377714B2
A trans-isomeric compound of formula (I) below or a pharmaceutically acceptable salt thereof: in which R1 is C1-C5 alkyl or C3-C5 cycloalkyl and the trans-isomeric compound has a trans:cis ratio of at least 70:30. Further disclosed is a method for preparing the trans-isomeric compound.
US10377707B2
A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm bacteriostatic compositions.
US10377698B2
Diphenethylamine derivatives for use as highly active analgesics, diuretics, anxiolytics, for the treatment of neurodegenerative, psychiatric and neuropsychiatric disorders, and also as anti-itch, anti-addiction, anti-inflammatory, anti-obesity, anti-epileptic, anti-convulsant, anti-seizure, anti-stress, anti-psychotic and anti-depressant medications and their pharmaceutically acceptable salts and easily accessible derivatives thereof (e.g. esters, ethers, amides), processes for their preparation and their application in the manufacture of pharmaceutical products.
US10377696B2
An apparatus for separating dimethyl carbonate using pervaporation includes: an atmospheric distillation column and a high pressure distillation column distilling a mixture containing dimethyl carbonate and methanol and separating dimethyl carbonate from the mixture; and a pervaporation membrane module disposed between the atmospheric distillation column and the high pressure distillation column and allowing for permeation of the methanol to separate the methanol from the mixture, thereby reducing heat consumption and a process cost as compared to the case of only using an existing pressure swing distillation method.
US10377689B2
Process for preparing polyoxymethylene dimethyl ethers having ≥3 oxymethylene units (OMEn≥3), comprising the steps:(i) introduction of formaldehyde, methanol and water into a reactor R and reaction to give a reaction mixture containing formaldehyde, water, methylene glycol, polyoxymethylene glycols, methanol, hemiformals, methylal (OMEn=1) and polyoxymethylene dimethyl ethers (OMEn>1); (ii) introduction of the reaction mixture into a reactive distillation column K1 and separation into a low boiler fraction F1 containing formaldehyde, water, methylene glycol, polyoxymethylene glycols, methanol, hemiformals, methylal (OMEn=1) and polyoxymethylene dimethyl ethers having from 2 to 3 oxymethylene units (OMEn=2-3) and a high boiler fraction F2 containing polyoxymethylene dimethyl ethers having more than two oxymethylene units (OMEn≥3).
US10377679B2
A kitchen waste treatment device in environment-protection-device field comprises a main fermentation barrel comprising a barrel body mounted on supporting brackets and including a feed inlet, a discharge outlet and a material chamber, push plates located within the material chamber to push materials therein to move along barrel body axial direction and further a gas inlet system having gas inlets located at same barrel body end as the discharge outlet and a gas-exhaust system having gas-exhaust ports located at same barrel body end as the feed inlet; a feeding apparatus whose feed end communicates with the feed inlet; and a power apparatus driving the barrel body to rotate around its axis. The gas inlets/gas-exhaust ports communicate with the material chamber. The treatment device has simple compact structure and small occupied area and realizes material horizontal propulsion and repeated rotational-stirring in the barrel body by barrel body rotation, achieving material-degrading-and-fermenting object.
US10377671B2
Conventional sintering processes convert a portion of cBN to hBN which is softer than cBN which negatively affects functional properties of an alumina composite. The invention is directed to method for making an alumina-cubic boron nitride (Al2O3-cBN) composite that contains substantially no hexagonal boron nitride (hBN) by non-conventional spark plasma sintering of cBN with nano-sized alumina particles. The invention is also directed to Al2O3-cBN/Ni composites, which contain substantially no hBN, and which exhibit superior physical and mechanical properties compared to alumina composites containing higher amounts of hBN.
US10377665B2
Embodiments of the disclosure provide an apparatus and methods for localized stress modulation for overlay and substrate distortion using electron or ion implantation directly to a glass substrate. In one embodiment, a process for modifying a bulk property of a glass substrate generally includes identifying a stress pattern of a glass substrate, determining doping parameters to correct a defect (e.g., overlay error or substrate distortion) based on the stress pattern, and providing a treatment recipe to a treatment tool, wherein the treatment recipe is formulated according to the doping parameters. The process may further include performing a doping treatment process on the glass substrate using the treatment recipe to correct the overlay error or substrate distortion. In some embodiments, the treatment recipe is determined by comparing the stress pattern with a database library containing data correlating stress changes in glass substrates to various doping parameters.
US10377661B2
Glass ceramics having SiO2 as main crystal phase and precursors thereof are described which are characterized by very good mechanical and optical properties and in particular can be used as restoration material in dentistry.
US10377660B2
A float glass sheet having a boron- and lithium-free glass composition comprising the following in weight percentage, expressed with respect to the total weight of glass: 65≤SiO2≤78% 5≤Na2O≤20% 1≤K2O<8% 1≤Al2O3<6% 2≤CaO<10% 0≤MgO≤8%; K2O/(K2O+Na2O) ratio which is from 0.1 to 0.7; wherein the glass sheet has: 0.01 < ( Na 2 O ) air ( Na 2 O ) tin - 1.03 ≤ 3. The glass sheet may be a chemically-temperable soda-silica type glass composition suitable for mass production that shows reduced or controlled increased warping effect.
US10377648B2
A system containing a reactor vessel including zero valent iron media, a source of a conditioning additive, a source of a reaction additive, and a process control subsystem is disclosed. A method for reducing a concentration of one or more contaminants in contaminated water including contacting zero valent iron media with a conditioning additive, contacting contaminated water with conditioned zero valent iron media, and introducing a reaction additive is also disclosed. The conditioning additive and reaction additive may each contain an aluminum salt.
US10377646B2
The present invention provides a method for producing electrolyzed water composition for use in cleaning and disinfecting of an object. The method comprises preparing an electrolyte solution comprising water, at least one carbonate salt selected from: alkali metal carbonate salts, and at least one chloride salt selected from: alkali metal chloride salts and/or alkali earth metal chloride salts. The method further comprises introducing the aqueous electrolyte solution into an electrolytic cell comprising a plurality of boron-doped diamond electrodes. The method further comprises operating a power supply to apply a predetermined voltage to the electrolyte solution to produce an electrolyzed water composition comprising a plurality of active molecular and ionic species with antimicrobial activity.
US10377642B2
A laser ablation and filtration process and apparatus wherein liquid containing hydrocarbons or other contaminates is purified. The liquid is exposed to laser energy at one or more selected wavelengths wherein the laser energy travels through the liquid and reaches the hydrocarbons or other contaminates and vaporizes, denatures, breaks down, neutralizes, renders inert and/or separates the hydrocarbons or contaminates from the liquid. A laser source is positioned in or on a vessel based on pre-set parameters to maximize exposure of the liquid to the laser energy, including sizing parameters, angle and inclination of the laser, retention time for the laser process to be applied and geometry of the containment for proper inclination. One or more collection chambers, which may include perforated membranes may be included to collect gases, separated hydrocarbons or contaminates and other by-products of the process. The vessel utilized may be submergible in water to pull or flow contaminated water therethough. The vessel may also be utilized outside a body of water wherein contaminated water from a source is introduced within the vessel.
US10377640B2
The present invention provides an electrode mixture, an electrode and a nonaqueous electrolyte secondary battery. The electrode mixture includes a lithium mixed metal oxide represented by formula (1): Liz(Ni1-x-yMnxMy)O2 (1), an electrically conductive material, and a water-dispersible polymeric binder, wherein x is 0.30 or more and less than 1, y is 0 or more and less than 1, x+y is 0.30 or more and less than 1, z is 0.5 or more and 1.5 or less, and M represents one or more members selected from the group consisting of Co, Al, Ti, Mg and Fe.
US10377637B2
In a method for manufacturing an aerogel, an acid is added to a first aqueous high-molar-ratio silicate solution that includes silica particles having a mean particle diameter of from 1 nm to 10 nm and that is alkaline, to produce a gel. The gel is subjected to a dehydration condensation to obtain a hydrogel. The hydrogel is converted into a hydrophobized gel. Then, the hydrophobized gel is dried. According to the method, an aerogel having a pore volume of from 3.00 cc/g to 10 cc/g, a mean pore diameter of from 10 nm to 68 nm, and a specific surface area of from 200 m2/g to 475 m2/g can be prepared.
US10377631B1
In one embodiment, a method of producing an sp3 bonded C3N4 product includes contacting a starting material with a catalyst solvent in a reaction vessel, heating the reaction vessel to a temperature of 900° to 2000° C. under a pressure of 4 to 8 GPa, melting at least some of the catalyst solvent, and transforming at least some of the sp2 bonded C3N4 into sp3 hybridized C3N4. The starting material may include sp2 bonded C3N4. The catalyst solvent may be a solid at room temperature. In one example, the catalyst solvent is a carbo-nitride based catalyst solvent including a first compound having the chemical formula AxByNz and a second compound having the chemical formula DqErCs. In a second example, the catalyst solvent is a metal alloy based catalyst solvent including a compound having the chemical formula GxHy.
US10377628B2
An energy carrier system is provided that produces ammonia with high efficiency and that further produces hydrogen as final product and uses the hydrogen as energy. An energy storage transportation method is further provided that is carried out by using energy carrier system. The energy carrier system includes nitric acid production device, an ammonia production device, and hydrogen production device. The nitric acid production device includes a photo-reactor, a gas supply unit that supplies photo-reactor with gas to be treated containing a nitrogen oxide, water, and oxygen, and light source disposed in the photo-reactor. The light source radiates light including ultraviolet of a wavelength shorter than 175 nm. The energy storage transportation method includes nitric acid production step of producing nitric acid from a nitrogen oxide, ammonia production step of producing ammonia through reduction of nitric acid, and hydrogen production step of producing hydrogen through decomposition of the ammonia.
US10377625B2
An optical device formed of a mirror wafer, a cap wafer, and a glass wafer. The mirror wafer includes a first layer of electrically conductive material, a second layer of electrically conductive material, and a third layer of electrically insulating material between the first layer and the second layer. A mirror element is formed of the second layer of the mirror wafer, and has a reflective surface in the bottom of a cavity opened into at least the first layer. A good optical quality planar glass wafer can be used to enclose the mirror element when the mirror wafer, cap wafer, and glass wafer are bonded to each other.
US10377609B2
A technique facilitates the insertion and/or extraction of an electronics cartridge with respect to a corresponding cartridge housing which may be used in a downhole tool, such as a logging tool. An insertion tool comprises a frame to which the cartridge housing may be coupled to enable insertion of a corresponding electronics cartridge. The insertion tool comprises a cartridge adapter which may be selectively engaged with the electronics cartridge. Additionally, the insertion tool comprises a cable system which may be mounted on the frame and coupled with the cartridge adapter. When a cable of the cable system is pulled by, for example, a cable winch, the cartridge adapter is moved in a direction which forces the insertion of the electronics cartridge into the corresponding cartridge housing. In some embodiments, the cable may be rerouted in the cable system to enable extraction of the electronics cartridge from the cartridge housing.
US10377603B2
A trailing portion of a sheet drawn out of a sheet roll is discharged with a simple configuration. In a case where a trailing portion of the sheet is drawn out of the sheet roll, a driven roller is brought into press-contact with a core of the sheet roll via the trailing portion, whereby the trailing portion is discharged by utilizing the rotation of the core of the sheet roll.
US10377600B2
A post-processing apparatus includes an ejection tray receiving a recording medium that is ejected, an elastic member urging the ejection tray upward in a vertical direction, a moving mechanism causing the ejection tray to move up and down in the vertical direction, and a driving source driving the moving mechanism.
US10377599B2
A convey path switching module includes a body and a switching mechanism. The body has first, second and third convey paths. The switching mechanism includes a first switching assembly, a first actuator, a second switching assembly and at least one elastic member. The first actuator drives the first switching assembly to pivotally rotate. The second switching assembly is adapted to pivotally rotate and is restored by an elastic force of the elastic member. By pivotally rotating of the first and second switching assemblies, the switching mechanism is switched to a first state to open the first convey path and close the second and third convey paths, is switched to a second state to open the second convey path and close the first and third convey paths, and is switched to a third state to open the third convey path and close the first and second convey paths.
US10377589B2
To enable placement of a regulating member which regulates a position of an end of a paper sheet at a desired position, and stable sheet feeding. A fixing member for standard size (33) is guided to engage with a fixing hole for standard size (42) and, in a state where the fixing member for standard size (33) positions a trailing end regulator (24), a fixing member for non-standard size (34) does not engage with a rack gear (43).
US10377586B2
A vehicle restraint for a loading dock includes a barricade member that is rotationally operable between a stored position, a blocking position and a verification position. The barricade member in the blocking position is adapted to laterally secure a vehicle relative to the loading dock. An operable latch is coupled proximate an outer end in the barricade member. The operable latch is selectively operable between retracted and extended positions. When the barricade member is in the blocking position and the operable latch is in the extended position, the operable latch vertically secures the vehicle relative to the barricade member.
US10377584B1
The retaining system for vertically stacked material is configured for use with a plurality of drywall sheets that are awaiting installation. The retaining system for vertically stacked material is a fastening device that secures the plurality of drywall sheets to a stanchion such that the plurality of drywall sheets will not fall during storage. The retaining system for vertically stacked material comprises a stanchion clip, a drywall clip, a securing strap, and a locating beacon. The stanchion clip attaches to the stanchion. The drywall clip attaches to a drywall sheet selected from the plurality of drywall sheets. The securing strap attaches the drywall clip to the stanchion clip. The locating beacon is a GPS based device that identifies the location and of the retaining system for vertically stacked material.
US10377575B2
A method of recognizing a conveyor belt wear condition is provided. Relationships between an apparent compressive stress in a wear resistance test and surface roughness of a sample and between the surface roughness and amount of wear per unit frictional energy of the sample are acquired. A wear condition of an upper cover rubber is recognized based on an apparent compressive stress generated on the upper cover rubber at a use site, and a database is created based on the relationships. Alternatively, relationships between an average wear pitch calculated from the surface roughness and viscoelastic properties of the sample and between the average wear pitch and an actual amount of wear of the sample are acquired. A wear condition of the upper cover rubber is recognized based on the viscoelastic properties of the upper cover rubber of the use site and a database is created based on the relationships.
US10377570B2
Device for merging at least two piece goods streams arranged at different heights, with an upper feed channel for receiving packages from an upper piece goods stream, and a lower feed channel for receiving packages from a lower piece goods stream, the feed channels extending between a first vertical plane and a parallel second vertical plane, whose distance from each other corresponds to a total channel width, the upper feed channel having a first conveying surface between a first side panel running in the first vertical plane, and a second side panel, the second side panel running in the second vertical plane at least on an upstream-side final section, and a second conveying surface, which downstream joins the first conveying surface adjacent to a third side panel running in the first vertical plane and has a width, which is less than half the total channel width, wherein the second conveying surface loosely ends on a side panel running parallel to the first vertical plane at a vertical distance above the lower feed channel, the lower feed channel having a third conveying surface, which is bordered by a fourth side panel running in the second vertical plane and by a fifth side panel, wherein a width of the third conveying surface at a downstream-side end of the lower feed channel corresponds to the total channel width less the width of the second conveying surface.
US10377569B1
The present invention relates to a horizontal or slopped decking panel for use with a storage rack. The decking panel may include a plurality of laterally spaced parallel structural beams have first and second ends and a metal sheet. The metal sheet may extend around and under the first and second ends of the structural beams to define a first panel edge and a first bottom return sheet portion. The metal sheet may extend around and under the second ends of the structural beams to define a second panel edge and a second bottom return sheet portion. The metal sheet may have a plurality of top perforations. The first and second bottom return sheet portions may have first and second rows, respectively, of bottom perforations. Each of the bottom perforations may be aligned with one of the top perforations so that a post of a divider wall can be received.
US10377568B2
An intermediate container is provided for receiving refuse from a primary refuse container that is configured to be carried by a top-loading refuse collection vehicle lifter. The intermediate container comprises a front wall, a rear wall, opposed sidewalls, and a bottom wall defining a total refuse collection volume. An extension assembly is located substantially beneath the total refuse collection volume intermediate the front wall and the rear wall, with a portion of the extension assembly being movable between a first, retracted position for storage and for dumping a primary refuse collection container and a second, extended position for engaging and releasing the primary refuse collection container at a location laterally spaced from the intermediate container refuse collection vehicle. A mounting base is secured to the extension assembly that is configured for mounting a primary refuse collection container lifter thereon. Further, the intermediate container is free of fork receivers and includes at least one mounting member for non-destructive removable attachment to the collection vehicle lifter.
US10377566B2
A trash collection assembly may include a dumpster housing which may house therein a dumpster to provide a more desirable aesthetic appeal. A garbage truck may be configured to lift the dumpster out of the dumpster housing without the need for the garbage truck driver to get out of the truck. A cover of the dumpster may open and close automatically respectively during the removal of the dumpster from the housing and return of the dumpster to the housing.
US10377558B2
The present disclosure relate to an actuator assembly for an aerosol can. The assembly includes a body attachable to a can and a disc provided with two opposing levers. The disc is hinged to the body and generally overlies a valve provided on the aerosol can. When either lever is depressed, a valve socket on the bottom of the disc engages the valve of the aerosol can to discharge pressurized liquid through a port formed through the disc. One of the levers is provided with a catching member that engages and selectively locks onto a latch provided on the body so that the lever is captured in a depressed position to cause the continuous discharge of liquid from the can. The captured lever can be released to discontinue discharge of liquid by pressing the other lever.
US10377551B2
A blow molded container includes a main member (20) forming a tool cavity. The main member (20) has an inner surface. The main member (20) further contains at least one corner portion (30) and at the corner portion (30), the main member (20) includes at least a first layer (40) and a second layer (42). The first layer (40) forming the inner surface, and the first layer (40) and the second layer (42) are affixed together along a predetermined pattern while being separated from each other elsewhere. The first layer (40) is formed with a first protruding part (143) along the predetermined pattern, and the second layer (42) is formed with a second protruding part (145) along the predetermined pattern. The first protruding part (143) and the second protruding part (145) are affixed together.
US10377549B2
A foldable bag comprises a front sheet and a back sheet which are circumferentially joined to each other. The bag is disposed in a folded condition in which the bag has a reversed T-shape including a bottom and an upward portion extending upwardly from the bottom. In the folded condition of the bag, upward portion side edges are inwardly creased between the front sheet and the back sheet such that they face to each other. At the bottom, an inner bottom edge portion extends substantially within a plane of the upward portion and each of outer bottom edge portions extend substantially parallel above the inner bottom edge portion.
US10377541B1
Embodiments of an illuminated liquid container are disclosed herein. The illuminated liquid container can include a light source that, when activated, emits light, and a switch that activates the light source. Some embodiments of the illuminated liquid container include a bottle for holding a liquid and a cap through which the liquid can be passed.
US10377540B2
A container cap configured to couple to an access opening of a container, and the access opening having a seal configured to cover the access opening. The container cap includes a cap body including a cylindrical-shaped side wall having a bottom edge that defines an opening to an interior of the cap body, and a top wall portion integrated with the cylindrical-shaped side wall and at least partially enclosing the interior of the cap body. The container cap further includes a seal opening assembly integrated with the cap body. The seal opening assembly includes a slot defined in the top wall portion of the cap body, and a seal piercing member formed on a first side of the slot. The seal piercing member is configured to pierce the seal covering the access opening.
US10377537B2
A liquid dispenser (10) for a container of liquid, comprises a spout (12) and a liquid uptake structure (18) aligned to provide liquid to the spout from a container. The liquid uptake structure has first openings (20) radially distributed at the spout end, second openings radially distributed around the container end and a third opening centrally located at the container end. The liquid uptake structure provides an airflow path through the second openings and a principle liquid flow path separate from the airflow path through the third opening, thus separating the two flow paths and providing a smooth pour.
US10377533B2
An elongated tubular housing adapted to receive an adjustable external compression device introduced on one end of the tubular housing distal from the opening releasing the contents, and retained in position by a member engaging a grooved strip that is integrated with and/or retained on the housing surface material with a strip surface of like material, providing a reliable, economic and functional outer compression member retention apparatus and method. Further embodiments according to the present invention include a dispenser having regions provided for ease and comfort of gripping, grooved strip end-stop to retain compression device, and grooved strip dimensional and placement details to provide functional, manufacturable and economic material dispenser.
US10377532B2
Provided is a hybrid-construct bag, comprising a bag body formed by at least a first sheet, the bag body having: a substantially tubular main body portion, a first end portion, a second end portion, a valve section formed at the first end portion and configured to form the channel between the top and bottom walls which are included in the valve section, and a patch section, wherein the main body portion, first end portion and second end portion cooperatively form a cavity operable to receive contents. There are a plurality of perforations formed in the main body portion and used for allowing a gas to pass though and resisting a liquid and/or particulates to pass though. A method of forming the hybrid-construct bag is also disclosed.
US10377528B2
A method, system, apparatus, or device to support or move objects. The apparatus may include a substrate and a rib structure. The rib structure may be disposed at an interior portion of the substrate. The rib structure may include a first chamber extending downwardly from a first plane to a second plane. A wall of the first chamber may taper inwardly to form a first inverted dome. The rib structure may include a second chamber extending downwardly from the first plane to the second plane to form a second inverted dome. A wall of the second chamber may taper inwardly to form a first inverted dome.
US10377520B2
A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.
US10377518B2
A recycling method is disclosed that includes the steps of compacting recyclable material into a fixed bale of recyclable material while concurrently weighing the OCC in the compactor and independently of the force that the compactor applies to the material or to the bale, assigning an individual identifier to the fixed bale in which the identifier includes at least the weight of the bale, and sending the fixed identified bale to a destination selected from the group consisting of shippers, mills, rebalers, or a customers for the baled recyclable material.
US10377517B2
An assembly system for wrapping an outer wrapper to an inner sleeve to form an outer wall of a double-wall container can include a moveable suction arm. The moveable suction arm can be configured to couple to a suction source and can have a portion defining a suction surface. A plurality of suction openings can be provided within the suction surface and fluidly coupled to the suction source. A sealing edge can circumscribe at least a portion of the suction surface.
US10377512B2
A method of metallizing a surface of a structure, and in some embodiments a mirror produced by such method, by the steps of providing a composite support structure; providing a release liner including a metallic layer having a thickness between 1 and 5 microns on a surface thereof; situating the release liner against the surface of the composite support structure so that the metallic layer of the release liner is placed in direct, physical contact with the surface of the support structure; and removing the release liner so that the metallic layer remains attached to the surface of the support structure.
US10377505B2
Passageway including a section that is extendable and retractable, the section including frame, slide track assemblies, and scissor bar assembly. The frame includes upright members on a first side of the frame. The slide track assemblies are disposed proximately to the upright members. Each of the slide track assemblies includes a slide track and a slide block. The slide track has a cavity and a channel. The slide block can ascend, descend, and rotate within the cavity. The slide block includes a guide block that extends from the slide block through the channel. The scissor bar assembly is secured to the upright members and slide blocks of the slide track assemblies such that the upright members are enabled to extend and retract with respect to each other along an arcuate path, wherein the guide block limits rotation of the slide block to rotation of the guide block within the channel.
US10377503B2
An engine assembly comprising an engine and a pod surrounding the engine that is equipped, upstream according to the direction of entry of air into the engine, with a fan provided with blades, the pod having an upstream air intake. The engine assembly also comprises a display unit including at least one light ring arranged in the air intake upstream of the fan, the light ring including at least one row of light-emitting diodes and being configured to emit at least one light beam and to project it on the blades of the fan.
US10377494B2
A divider assembly that includes a main body portion having a lower section and an upper section and a removable panel having front and back surfaces. The upper section tapers in width in an upward direction and the main body portion includes front and back surfaces. The removable panel is removably secured to the upper section on the front surface of the main body portion.
US10377493B2
A mobile galley cart including a wheeled insulated housing having a door configured to open to access to the interior of the housing, a thermoelectric chiller mounted near the bottom of the cart, cold air ducting in fluid communication with the thermoelectric chiller and opening to the interior of the housing, and warm air ducting including a warm air exhaust arranged to exhaust warm air from the mobile galley cart. A mobile galley cart system including a cart configured to dock at a separate service wall to provide service connections therebetween.
US10377488B1
A tandem-wing unmanned aircraft system (UAS) includes forward and aft wings mounted to the fuselage by frangible spar elements, the forward wings in a shoulder-wing configuration and the aft wings in a low-wing configuration. The forward and aft wings may incorporate fill-span multifunctional control surfaces on their trailing edges. The wing design prevents interference with airflow over the fuselage into a tail-mounted ducted propeller assembly, which pivots to provide vectored thrust. A nose compartment at the nose end of the fuselage may include a forward-mounted camera with a hemispherical field of view, the nose camera protected by transparent exterior panels. A ventral cargo compartment mounted amidships may include a ventral camera gimbal-mounted to provide an overhead perspective; the ventral camera may be gimbal-mounted for articulation along multiple rotational axes to provide additional views of the UAS exterior.
US10377487B2
A display device, configured to display an image photographed by a camera mounted on a remotely controlled mobile object, includes a display part which is mountable on a head of a user and capable of displaying an image, a receiving part configured to receive a photographed image and position information of the mobile object transmitted from the mobile object, a position detection part configured to detect a position of the display part, a direction detection part configured to detect a direction of the display part, and a controller configured to control image displaying on the display part, determine whether the mobile object exists in the direction of the display part and within a particular range with respect to a position of the display part, and switch images to be displayed on the display part depending on whether the mobile object exists within the particular range or not.
US10377486B2
A drone speaker system is configured to deploy a fleet of drone speaker units. Each drone speaker unit includes a speaker configured to broadcast acoustic signals and a flight system configured to aerially transport a speaker. The drone speaker system initially generates a spatial map of a location where the drone speaker units are to be deployed. The drone speaker system then identifies suitable perching locations for the drone speaker units. Then, the drone speaker system deploys the fleet of drone speaker units to those perching locations to place one or more speakers. Once positioned in this manner, the speakers can generate a sound field. The drone speaker units may also reconfigure the speakers to achieve different sound fields having varying characteristics.
US10377483B2
This disclosure describes an aerial vehicle, such as an unmanned aerial vehicle (“UAV”), which includes a plurality of maneuverability propulsion mechanisms that enable the aerial vehicle to move in any of the six degrees of freedom (surge, sway, heave, pitch, yaw, and roll). The aerial vehicle may also include a lifting propulsion mechanism that operates to generate a force sufficient to maintain the aerial vehicle at an altitude.
US10377482B2
A manned/unmanned aerial vehicle adapted for vertical takeoff and landing using the same set of engines for takeoff and landing as well as for forward flight. An aerial vehicle which is adapted to takeoff with the wings in a vertical as opposed to horizontal flight attitude which takes off in this vertical attitude and then transitions to a horizontal flight path. An aerial vehicle system which has removable wing sections which allow for re-configuration with different wing section types, allowing for configurations adapted for a particular flight profile. A method of customizing a configuration of an unmanned aerial vehicle based upon flight profile factors such as duration, stability, and maneuverability.
US10377480B2
A variable thrust cross-flow fan system for an aircraft including a rotatable wing member having a first housing member; an actuator assembly operably coupled to the first housing member; and a variable thrust cross-flow fan assembly including a first and second driver plates having a plurality of blades rotatably mounted therebetween. The plurality of blades has a circular path of travel when rotating and includes a control assembly coupled to the plurality of blades to generate a variable thrust force. The control assembly includes a control cam that is substantially non-rotatable relative to the first and second driver plates and a hinge member that is fixedly connected to the control cam and to the first housing member at a hinge axis. Rotation of the first housing member by the actuator assembly imparts rotation of the control cam about the hinge axis, thereby changing the direction of the variable thrust force.
US10377471B2
An apparatus, method and system for combining aerodynamic design with engine power to increase synergy between the two and increase climb performance, engine-out performance, and fuel efficiency for a variety of aircraft or the like.
US10377465B2
The present invention is a variable geometry aircraft that is capable of morphing its shape from a symmetric cross-section buoyant craft to an asymmetric lifting body and even to a symmetric zero lift configuration. The basic structure is a semi rigid airship with movable longerons. Movement of the longerons adjusts the camber of the upper and/or lower surfaces to achieve varying shapes of the lifting-body. This transformation changes both the lift and drag characteristics of the craft to alter the flight characteristics. The transformation may be accomplished while the craft is airborne and does not require any ground support equipment.
US10377462B2
A decompression assembly for use in an aircraft comprises a cabin lining element, an opening formed in the element, and an air channel arranged adjacent to a rear face of the element and connected to the opening. The air channel is provided with an air outlet which, during normal operation of the assembly, discharges air exiting a cabin region delimited by the element through the opening into an area located between the element and an aircraft outer skin, a first decompression opening, and a first decompression flap which, during normal operation of the decompression assembly, closes the first decompression opening in the air channel and which, in the event of a rapid decompression, opens the first decompression opening to allow a pressure equalization between the aircraft cabin region and the aircraft area located between the cabin lining element and the aircraft outer skin.
US10377460B1
A modular drive apparatus includes a gear box (16) with a rotatable internal transmission gear (60). The gear box includes a plurality of body openings (44). The openings may be selectively closed by the installation of cover plates (52, 54). With a cover plate removed, a drive coupler (32, 34, 58, 148) may be extended in the respective opening and mounted in operative connection with the gear box. In the mounted position of the drive coupler, an idler gear (72, 172) engages the ring gear of the gear box. Rotatable power devices such as pumps, motors and generators may be operatively rotatably engaged with the drive coupler.
US10377451B2
A canoe and platform combination assembly includes a platform that has a top side, a bottom side, a front edge, a rear edge, a first lateral edge and a second lateral edge. A plurality of arms is attached to the platform. The arms engage canoes positioned adjacent to the first and second lateral sides such that the canoes are orientated parallel to each other. A plurality of tethers is provided. Each of the arms has one of the tethers positioned thereon. Each of the tethers is positioned around one of a plurality of braces of the canoes.
US10377450B2
An offshore structure is separated into an upper structure and a lower structure. Part or whole of the lower structure is kept in an upright standing state in water. The upper structure is moved to above the lower structure kept in the upright standing state. A uniting step includes one or both of raising the lower structure to arrange the lower structure on a lower side of the upper structure and lowering the upper structure to arrange the upper structure on an upper side of the lower structure by submerging part of a carrier vessel on which the upper structure is mounted while being held by a pair of arm-shaped structures of the carrier vessel and integrating the lower structure with the upper structure. In this way, an offshore structure is moored safely at an offshore installation site without using a crane vessel.
US10377438B2
A bicycle frame assembly including a seat tube having first and second end portions (wherein the seat tube second end portion includes a bend and terminates in a first open end facing a first direction), a down tube having first and second end portions (wherein the down tube first end portion is mounted to the seat tube first end portion, and the down tube second end portion includes a bend and terminates in a second open end facing a second direction opposite to the first direction), and a top tube having first and second end portions (wherein the top tube first end portion is mounted to the seat tube second end portion and terminates in a third open end facing the first direction, and the top tube second end portion is mounted to the down tube second end portion and terminates in a fourth open end facing the second direction).
US10377436B2
A side cover structure for a motorcycle, which is to be arranged for covering a lateral side of the motorcycle, comprising a side cover that covers a lateral side of an air cleaner above the engine and includes a window for allowing vision therethrough. The side cover is provided with a side lower cover, which covers below the side cover and includes a surface portion for attaching from inside of the window of the side cover, and a garnish, which is made attachable/detachable to/from the outside of the window. The surface portion of the side lower cover carries a design shape thereon for being seen when the garnish is taken off from the side cover at the window. Such configuration provides the user to change the appearance of side cover structure of the motorcycle, thereby providing various styles of the side cover structure by the user preference.
US10377435B2
A multi-function bicycle component which fastens to a bicycle and which is rotatable relative to the bicycle frame to multiple positions to serve as a cargo rack or luggage carrier in a first position and a bicycle stand or kickstand in a second position. The multi-function bicycle component rotates at or near the wheel axis and comprises a rotation preventing assembly which fastens the multi-function bicycle component relative to the bicycle frame in a riding position. When used in conjunction with a folding bike, the multi-function bicycle component also serves as a stand to assist during the folding process, and/or as a stand when the bicycle is in the folded position. The multi-function bicycle component may also include a bicycle fender.
US10377429B2
A rear spoiler of a motor vehicle. The spoiler includes a first part intended for being attached to the rear of the vehicle in an attachment position by a first attachment means, and a second part which is intended for being removably attached to the first part in an attachment position by a second attachment means, the second part leaving a portion of the upper surface of the first part visible in this attachment position.
US10377424B2
In a bonnet of a tractor having an upper cover and a pair of lower covers, the upper cover has a center line formed from a front end point up to a diagonally-rearward midpoint, and the upper cover is provided with two opening parts sandwiching the center line. In addition, the opening parts are disposed so that one side of each follows the center line.
US10377419B2
A steering shaft for a motor vehicle may include a first shaft part and a second shaft part. The first and second shaft parts may be connected in a way such that torques are transferred. A damping element can be disposed between the first and second shaft parts for damping oscillations and/or vibrations. The damping element may contact a carrier along a contact area. The damping element may be coupled to the carrier at only a portion of the contact area. The carrier may be, for example, the first shaft part, the second shaft part, a sleeve, or a bushing.
US10377417B2
A method for detecting a control situation of a vehicle comprising an automatic control system. A steering torque curve applied to the steering of the vehicle is subdivided into sections in which the steering torque curve steadily rises or falls, and an angular acceleration caused by a driver and detected by a first steering angle sensor at the beginning of the respective section by a first part of the steering rod as a first angular acceleration is compared to a second angular acceleration detected by a second steering angle sensor at the beginning of a respective section caused by an automatic control system with a toothed rack connected to the steering rod or a second part of the steering rod. Depending on a result of the comparison, a corresponding steering torque curve of the respective section is assigned to the driver or to the automatic control system.
US10377413B2
An electronic control unit diagnoses a short failure of an inverter FETs and diagnoses whether the failure of the FET-short detecting section has occurred. The unit controls a motor through an inverter including a bridge having an upper-stage FETs and a lower-stage FETs via an MCU, having: an FET-short detecting section to detect a short failure of the upper-stage FETs and the lower-stage FETs based on respective connection point voltages of the upper-stage FETs and the lower-stage FETs; and a diagnostic function to detect a failure of the FET-short detecting section. The diagnostic function diagnoses the failure of the FET-short detecting section at start up and turns-OFF the upper-stage FETs and the lower-stage FETs when the failure is detected. The FET-short detecting section diagnoses the short failure of the upper-stage FETs and the lower-stage FETs when the failure of the FET-short detecting section is not detected.
US10377403B2
A lift-enabled motorized wheel assembly and material handling cart. A drive wheel is supported on an axel between a fixed leg and a floating leg. The axel passes through the fixed leg without interference, but is captured in the floating leg by a self-aligning bearing. The axle is driven by a drive motor that is bolted to the fixed leg through a right-angle gearbox. A vertical suspension unit provides compliance for drive wheel traction. A lifter sub-assembly alternately raises and lowers the drive wheel into and out of contact with the ground. The lift-enabled motorized wheel assembly is attached to the bottom of a cart frame, along with a plurality of caster wheels. The cart includes a tow-bar that is moveable between raised and lowered positions. When the tow-bar is lowered condition for towing, the drive wheel automatically lifts out of contact with the ground.
US10377402B2
A disc golf bag cart which includes a front wheel, two rear wheels, and a cart frame. The front wheel and the rear wheel are provided at the bottom portion of the cart frame. The top portion of the cart frame includes an upper rotatable bag stabilizer, the middle portion of the cart frame includes a middle bag stabilizer, and the bottom portion of the cart frame includes a lower tightenable bag stabilizer. The disc golf bag carrying the disc golf can be secured onto the cart through the mechanisms of the upper rotatable bag stabilizer, the middle bag stabilizer, and the lower tightenable bag stabilizer. Comparing to conventional trolley cart, the disc golf bag cart of the present invention is capable of fitting disc golf bags with different shapes and sizes.
US10377401B2
A mobile platform comprising: (a) one or more platforms to support one or more cartridges, (b) one or more compartments within the one or more platforms, (c) one or more vertical supports connected to the one or more platforms, (d) a plurality of wheels connected to a bottom of the one or more platforms, and (e) one or more recesses located in the one or more platforms to receive one or more support accessories, wherein the one or more compartments are shaped to receive the one or more cartridges so that the one or more cartridges are secured to the one or more platforms during movement.
US10377396B2
The invention is an amusement-park device, comprising a rail-guided route course and at least one vehicle guided on the rail, which vehicle has a brake apparatus having at least one, preferably two brake pads fastened to a brake-pad carrier, which brake pads are provided for braking or clamping the vehicle at a point of the rail-guided route course during a braking event. According to the invention, the brake apparatus has a brake carrier and/or the at least two brake pads can be pivoted in relation to the stationary bike carrier. The vehicle equipped with such a brake apparatus can follow unevenness in the rail-guided route course in a simple manner, resulting in reliable braking behavior.
US10377392B2
An autorack railroad car has decks that are movably reconfigurable between tri-level and bi-level configurations. They are also movable to permit greater vertical clearance room for loading the main deck. The decks may be constrained to a single degree of freedom of motion, namely in the vertical direction, by guides that run along the vertical side posts of the car. The decks may include a passive counterbalance transmission linking the mid-level and upper level decks, such that the decks counterbalance each other when the decks are moved between the various positions. There is a separate, independent drive provided to move the decks. The drive may include scissor jacks. More than one scissor jack may share a common drive axis and shafting arrangement. The drive is operable from a trackside accessible drive distribution point. A secondary lock system is provided to prevent the decks from moving inopportunely.
US10377391B2
The invention relates to a winch system intended, in particular, for water sports, comprising at least one frame, at least one motor, a brake system, and a main tension cable wound around two spools, each spool being actuated by a motor such that when one of the spools unwinds the main cable, the other spool winds up the cable such as to maintain both the unwinding speed and the tension required for the main cable.
US10377390B2
The invention relates to an automated driving system for a motor vehicle including a visual communication interface intended for informing the driver about the state of said driving system and comprising a luminous indicator capable of emitting luminous signals on the steering wheel of said vehicle; characterized in that said visual communication interface also includes a heads-up display capable of displaying other luminous signals in the field of view of the driver beyond the dashboard of said vehicle.
US10377389B2
A vehicle includes a controller that prompts a user to confirm a willingness to accept a reduced maximum acceleration or speed responsive to user confirmation of a desire to increase an electric drive range by a user selected amount. The controller further operates a propulsion system with the reduced maximum acceleration or speed to increase the electric drive range responsive to user confirmation of the willingness.
US10377387B2
One way to improve fuel efficiency of a vehicle is to detect the vehicle operational shortcomings related to fuel consumption by determining whether fuel used during operation of the vehicle is normal fuel use or wasted fuel use. Considerations of idling, speeding and inappropriate gear shifts are some ways to measure the amount of fuel wasted due to operator shortcomings. Communicating this information to the operator in real-time so adjustments can be made will improve vehicle fuel efficiency. These techniques are applicable to tracking employment of other driving best practices as well.
US10377385B2
The invention provides a road surface condition determining system with improved accuracy. In the system, a plurality of vehicles Wi are used, each equipped with on-board sensors (11, 12) for acquiring vehicular information, which is information on the behavior of the vehicle during travel, a feature value calculating means (13) for calculating a plurality of feature values to be used in estimating the condition of the road surface on which the vehicle is traveling from the vehicular information acquired by the on-board sensors (11, 12), and a transmitter 16 for transmitting the feature values to the outside of the vehicle. A server (20) has a data storage means (22) for accumulating the plurality of feature values from the plurality of vehicles. A road surface condition determining unit (30) determines a road surface condition using the accumulated feature values. And the system determines the road surface condition at the location within a predetermined range within a predetermined space of time.
US10377381B2
A method and system for operating an autonomous vehicle. The method includes determining, at an electronic processor, a limit for a forward velocity setpoint of the autonomous vehicle based a range of a forward facing sensor and detecting whether a preceding vehicle is in a field of view of the forward facing sensor. The method includes determining a speed of the preceding vehicle, and when the preceding vehicle is in the field of view of the autonomous vehicle, adjusting the limit based on the speed of the preceding vehicle.
US10377374B1
The present radio system transmits an electromagnetic signal to nearby devices requesting the device respond. The radio system also receives responses to the electromagnetic signal from the nearby devices. Based on the radio technology used, the signaling of the transmitted electromagnetic signal may be varied. For example, the transmitted electromagnetic signal may be a Bluetooth, 802.11, or other radio signal. A device that received the signal from the radio unit may transmit a response signal with the same radio technology. However, in some instances, the radio technology used for communication may operate on several radio (e.g., frequency) channels. Both the transmitter and receiver must operate on the same channel at the same time in order to communicate. Thus, it may be desirable to transmit the electromagnetic signal on more than one channel at the same time, in order to increase the chances that a nearby device responds.
US10377371B2
In some embodiments, a rapid-response active suspension system controls suspension force and position for improving vehicle safety and drivability. The system may interface with various sensors that detect safety critical vehicle states and adjust the suspension of each wheel to improve safety. Pre-crash and collision sensors may notify the active suspension controller of a collision and the stance may be adjusted to improve occupant safety during an impact while maintaining active control of the wheels. Wheel forces may also be controlled to improve the effectiveness of vehicle safety systems such as ABS and ESP in order to improve traction. Also, bi-directional information may be communicated between the active suspension system and other vehicle safety systems such that each system may respond to information provided to the other.
US10377362B2
A braking control system for a trailer includes a braking system on a semi-trailer with the brake application handle located at the inside rear of the trailer. The handle has a locking member so that personnel loading the trailer are able to apply and lock the brakes on the trailer, and only the person(s) holding the key are able to release the brakes. The system prevents the trailer from moving away from the dock plate and having the dock plate fall through the space between the moved trailer and the dock, injuring personnel and/or damaging equipment.
US10377354B2
A vehicle speed management apparatus acquires scene information about a driving scene of a host vehicle, estimates the driving scene based on the scene information acquired, acquires behavior information about a driving behavior of a user, determines a driving risk of the host vehicle driven by the user, based on the driving scene estimated and on the behavior information acquired, and controls a presentation of assist information by an information presentation unit in order to prompt the user to address the driving risk. When the driving scene estimated represents an independent traveling state of the host vehicle, the assist information to be presented by the information presentation unit is selected based on a magnitude of the driving risk determined before an operation by an emergency control unit.
US10377347B2
A low-profile ventilation system is provided for a motor vehicle. That low-profile ventilation system includes an inlet duct having an inlet-free top wall, a sidewall and a bottom wall. A recirculating air inlet is provided in the sidewall. A fresh air inlet is also provided in the sidewall. A related method of providing a low-profile ventilation system is also provided. The method includes providing an inlet duct with an inlet-free top wall and both a fresh air inlet and a recirculating air inlet, wherein the recirculating air inlet has first and second laterally opposing openings in a sidewall of the inlet duct.
US10377345B1
A plug-in vehicle electronics module for use in vehicle sharing systems, and a method and system for using the vehicle electronics module. The vehicle electronics module includes an on-board diagnostic (OBD) connector and a housing that contains: a short-range wireless communication (SRWC) circuit; a microcontroller; and memory communicatively coupled to the microcontroller, wherein the memory stores a computer program; wherein the vehicle electronics module is connectable by the OBD connector to an OBD port on a vehicle; and wherein, when the vehicle electronics module is connected to the OBD port, the microcontroller operates under control of the computer program to cause the vehicle electronics module to: establish a short-range wireless communication (SRWC) connection with a personal SRWC device using the SRWC circuit; authenticate the personal SRWC device in response to receiving authentication information over the established SRWC connection; and in response to the successful authentication, provide access to the vehicle.
US10377342B1
A seat-belt monitoring system can be used with self-driving vehicles. A self-driving vehicle can include a belt sensor configured to detect a buckled state of a seat belt. The self-driving vehicle can include an occupancy sensor configured to detect a rider sitting in a seat. The seat-belt monitoring system can receive buckle and occupancy data from multiple self-driving vehicles and then can respond in ways configured to promote increased seat belt use.
US10377340B2
A restraint system includes a housing, a spool rotatably coupled to the housing, and an actuator fixed relative to the housing. The spool has a base plate with holes. The holes are spaced from each other circumferentially about the spool. The actuator has a pin movable between an engaged position extending into one of the holes and a disengaged position spaced from the holes.
US10377338B2
A device at least for moving a mass includes a hollow cylindrical airbag fluidically coupled to a gas generator. The airbag is arranged fixedly with one end on an object and a traction element is fixed in the region of an opposite end. The mass to be moved is arranged on the traction element. When the airbag unfolds traction is exerted on the traction element in such a way that the mass is able to be moved.
US10377336B2
An air bag chute assembly for an automotive instrument panel is injection molded to form an integral deployment chute, door, and attachment flange, The flange attaches to the instrument panel around an aperture in the instrument panel. The tubular chute extends interiorly from the flange to a lower end configured to receive an inflating air bag from an air bag module and defines a deployment path along a longitudinal axis. A door flap is disposed in an upper end of the chute rotatable from the flange to emerge through the aperture. The flap has an interior side impacted by the inflating air bag carrying a plurality of raised strengthening ribs. The flap has at least one closed-section hollow channel protruding from the interior side to a channel height extending beyond the strengthening ribs formed by gas-assist injection molding.
US10377335B2
A steering wheel includes a metal core earthed to a body of a vehicle, an airbag device, an insulator, and a connector. The airbag device includes a bag holder supported by the metal core, wherein the bag holder forms part of a positive electric path connected to a horn device, an airbag coupled to the bag holder by a fastener, and an inflator including a circumferential portion that forms a flange, wherein the flange of the inflator is coupled by the fastener to the bag holder. The insulator insulates the bag holder from at least the flange and the fastener among elements of the airbag device. The connector electrically connects at least the flange, among the flange and the fastener, to the metal core.
US10377332B2
A safety-relevant system (S) in a vehicle comprises an electrical unit (EE) with at least one signal line input (SE). The signal line input (SE) is connected to a signal line. The electrical unit (EE) additionally comprises a supply connection (VA) for feeding the electrical unit (EE) with electrical energy. For supplying electrical energy to the electrical unit (EE), the signal line is in addition electrically coupled to the supply connection (VA) of the electrical unit (EE).
US10377327B1
A curvature regulating member includes a plurality of member pieces to be arranged along a wire harness and a flexible connecting part connecting adjacent member pieces. The adjacent member pieces are configured to contact each other, thereby regulating curvature of the wire harness on an X-Y plane. Each member piece includes a recessed part recessed toward a direction away from an adjacent member piece on one side, and a second protrusion configured to be inserted in the recessed part provided on an adjacent member piece on another side when adjacent member pieces contact each other. The recessed part includes a slanted face extending away from the adjacent member piece on the one side as leaving from both ends in a widthwise direction. The second protrusion includes a slanted face extending toward the adjacent member piece on the another side as leaving from both ends in the widthwise direction.
US10377320B2
A vehicle glazing includes a glazed element, at least one mounting plate for the reversible attachment of an accessory to the glazed element, the mounting plate having an exterior face which is fixed facing an interior face of the glazed element, and including at least one mount for the reversible attachment of another accessory to the glazed element, wherein the mount is mechanically connected by at least one connecting arm connecting the mount to the mounting plate and the mount having an exterior face which is fixed facing an interior face of the glazed element.
US10377318B1
A support bracket attaches to a standard automobile trunk lid or hatch lift gate locking mechanism to hold a variety of accessory items including an umbrella above the head of a user. The bracket is adjusted and clamped in tightness to the lift gates locking mechanism whereas to secure it without movement to the trunk or hatch lid. It is released using the standard factory provided vehicle trunk or lift gate release mechanism. The device can be used independent of any hand support when the user is adjacent the open trunk or hatch of an automobile. Accessories are placed into a releasable engagement with the bracket sleeve, which may be separately adjusted relative to the main bracket assembly to position the accessory advantageously to the individual behind the vehicle. The umbrella accessory allows for an unobstructed shelter from precipitation and sun.
US10377316B2
A pop-up console apparatus for a vehicle may include a console housing disposed in a vehicle; a cover device disposed on the console housing to cover or pop open a top portion of the console housing; and one or more lower trays sequentially disposed under the cover device, wherein at least one of the lower trays moves up and down along a guide that is coupled to an end portion of the cover to pop up together with the cover while being inserted into the console housing.
US10377306B2
Systems and methods providing engine harmonic enhancement receive a first signal representative of a load on an engine and generate a control parameter based on the first signal. One or more harmonic scaling elements generate a scaled version of an engine harmonic signal based on the control parameter. Each harmonic scaling element includes a harmonic specific mapping element for mapping the control parameter to a scaling factor, wherein at least some of the scaling factor values of the harmonic specific mapping element are mapped to control parameter values associated with a negative load on the engine.
US10377290B2
A grain cart is provided that automatically rotates a spout of an auger assembly out of the way of a storage hopper when the auger assembly is folded into a transport position. The grain cart can include a storage hopper and an auger assembly to discharge particulate material from the storage hopper out of the grain cart. The auger assembly has a lower auger section and an upper auger section. A discharge assembly is pivotally attached to a discharge end of the upper auger section. To put the auger assembly in the transport assembly, the upper auger section is pivoted adjacent to the lower auger section. A cross-over electrical connection electrically connects a fold electrical connection and a pivot electrical connection, to cause the discharge assembly and spout to be pivoted towards a front of a grain cart when the auger assembly is folded into the transport position.
US10377289B2
A 240 degrees radially rotatable deck assembly rotatable in either direction without requiring resetting in a park position and requiring only a rotatable outer ring of a slew gear connected to a rotatable sub-frame attached to the deck, a fixed inner ring of the slew gear affixed to a fixed sub-frame fixed to a frame of the assembly and only a single hydraulic motor requiring no cylinders and only one main valve body with incorporated electric solenoids reducing the complexity of the plumbing and the weight of the assembly resulting in lower construction and maintenance costs, improved fuel economy and allowing an increased load weight. The assembly includes a positive holding brake that eliminates blow-by of the rotating section and is rotatable in either direction without requiring being reset in a park position. Such a deck is especially useful on a tow truck.
US10377286B2
A mechanism for folding a head restraint for a backrest of a seat, including a head restraint and a cross portion, where the cross portion is fixed relative to the backrest. The cross portion defines a first pivot axis, which the head restraint is pivoted about. The cross portion includes a locking disc. The head restraint comprises a cam that pivots about a second pivot axis. The head restraint is configured to be positioned in a usage-position relative to the cross portion and a storage-position relative to the cross portion. The position of the head restraint is changeable between the usage-position and the storage-position by pivoting about the first pivot axis. The cam is configured to be positioned in a locking-position and a releasing-position relative to the head restraint.
US10377284B2
A holder assembly includes a connector positioned at a first end of the holder assembly. An accessory-engagement portion is positioned at a second end of the holder assembly. The accessory-engagement portion is configured to removably couple with an accessory. An arm is positioned between the first end and the second end. An attachment elbow is positioned between the arm and the connector. The attachment elbow is pivotable about a hinge.
US10377282B2
A method of method of manufacturing an upholstered chair for a mass transit vehicle includes forming a seat insert and a backrest insert, injection molding a layer of upholstery having enveloping flanges and beads at a periphery thereof, placing the upholstery onto the seat and backrest inserts such that the flanges and beads engage with an underside of the inserts, and attaching the seat insert and the backrest insert onto a chair frame. The flanges and beads secure the upholstery to the seat and backrest insert.
US10377280B2
A vehicle seat includes: a seat frame that is provided as a strength member and extends in a specific direction, the seat frame including: a closed section frame having a closed sectional shape and extending in the specific direction, an opened section frame having an opened sectional shape and extending in the specific direction in parallel with the closed section frame, wherein the opened section frame is coupled with the closed section in a state to have a closure forming part and a gradually changing structure, wherein the closure forming part forms a closed sectional shape between the opened section frame and the closed section frame, and wherein the gradually changing structure changes the closed sectional shape formed between the opened section frame and the closed section frame at the closure forming part.
US10377279B2
A seating assembly includes a seatback having a frame and a cushion assembly. A cushion carrier includes a lower member defining a frame receiving cavity. A first set of ribs extend across the frame receiving cavity in a direction perpendicular to a longitudinal extent of the lower member. The first set of ribs extend between the lower member and a lower brace of the frame. A second set of ribs are parallel with the first set of ribs. The second set of ribs are longer than the first set of ribs.
US10377275B2
An occupant support adapted for use in a vehicle includes a seat frame, a seat pad, and a suspension system. The seat frame is adapted to couple with the vehicle for movement with the vehicle. The seat pad is adapted to provide a comfortable support interface. The suspension system provides relative movement between the seat pad and the seat frame.
US10377273B2
A vehicle seat includes: a seat cushion; a seat back; a frame; a headrest which is provided on an upper end portion of the frame; and a reclining portion wherein: the reclining portion includes: a link supporting the seat back at a swing end section; a sector gear rotated integrally with the link; a lock unit configured to move between an engaging position and a disengaging position for releasing from the engagement with the sector gear and configured to unrotatably hold the sector gear at the engaging position; and a biasing section biasing the lock unit toward the engaging position; and the lock unit includes: a pinion gear meshing with the sector gear at the engaging position and allowing rotation of the sector gear by rotating in a state of meshing with the sector gear; and a gear holding part configured to unrotatably hold the pinion gear.
US10377272B2
In order to suppress a claustrophobic feeling that a person sitting on a rear seat receives due to a front seat, and to make the front seat easy to use as an ottoman by the person, a movement adjustment system is used for a passenger seat and a rear seat, and includes a slide rail for moving the rear seat in the front to back direction, and a control part for changing the movement region of the rear seat by the slide rail. The passenger seat has a seat cushion, and a seat back mounted to be changeable between an upright state and a lowered state with respect to the seat cushion. The control part changes the movement region so that the passenger seat and the rear seat can come closer when the seat back of the passenger seat is in the lowered state than in the upright state.
US10377252B2
Robots and apparatus, systems and methods for powering robots are disclosed. A disclosed conductive floor to power a robot on the floor includes a plurality of stationary conductors positioned in a pattern and a power delivery circuit to cause adjacent ones of the conductors to have different electrical potentials, the adjacent ones of the conductors to form a circuit to deliver power to the robot via contacts formed in a bottom surface of the robot.
US10377251B2
An electric vehicle charging system includes a charging interface positioned on an external surface of the electric vehicle and one or more electrodes positioned on the charging interface. The charging system may also include a heating system positioned on the charging interface. The heating system may be configured to heat at least a portion of the charging interface. The charging system may also include a control system configured to selectively activate the heating system based at least on one or more ambient conditions.
US10377244B2
A braking control method includes steps of: (i) confirming whether to enter a blending section where regenerative braking torque is reduced and friction braking torque is increased; (ii) determining a target reduced deceleration by a controller upon entering the blending section; (iii) reducing braking torque of a vehicle in response to the determined target reduced deceleration; and (iv) returning the braking torque of the vehicle to driver's requested braking torque when the vehicle is being stopped.
US10377238B2
There is provided a configuration, including a storage unit that stores a theoretical driving wheel rotating speed based on a correspondence relationship with a predetermined engine speed in each gear stage of a transmission of a vehicle; gear stage detection means for detecting the gear stage when currently travelling; engine speed detection means for detecting an engine speed; driving wheel rotating speed detection means for detecting a driving wheel rotating speed; and torque control means for controlling output torque, in which the output torque is increased so that a current driving wheel rotating speed becomes close to the theoretical driving wheel rotating speed when a relative value of a calculated value which is calculated by using the detected driving wheel rotating speed with respect to a calculated value which is calculated by using the theoretical driving wheel rotating speed is equal to or greater than a first threshold value.
US10377230B2
A filler cap for a fuel tank is disclosed that can prevent environmental pollution and also improve fuel consumption without discharging fuel or harmful gas evaporated therefrom to an exterior of the fuel tank, until a pressure in the fuel tank reaches a predetermined value. In summary, immediately after attaching the filler cap to a fill opening, pressures are balanced between an interior and an exterior of the fuel tank. A spring raises a valve body and the rise/fall member, so that a lateral outer circumference of the valve body point contacts with plural convex portions of a second side wall, thereby closing the valve portion. In such a state, coming and going of a fluid between a first space and an opening is not allowed. When a pressure in the fuel tank reaches 5 kPa, the fluid rise a first air passage formed in spaces between respective convex portions on the second side wall, passing the valve portion. Rising fluid lowers the valve body to allow discharging an excessive pressure to the exterior of the fuel tank.
US10377229B2
A fuel storage assembly for a vehicle includes a fuel tank defining a fuel chamber, a fuel pump module and a vapor pressure detection system. The fuel pump module includes a flange engaged to the fuel tank and a fuel pump assembly supported by the flange and disposed in the fuel chamber. The vapor pressure detection system includes a vapor pressure sensor attached to the flange, a vapor pressure inlet device disposed in the fuel chamber, and a conduit communicating between the vapor pressure inlet device and the vapor pressure sensor.
US10377225B2
A mining machine including a bi-directional electrical bus, a power source coupled to the bi-directional electrical bus, a motor coupled to the bi-directional electrical bus, the motor powered by energy available on the bi-directional electrical bus, a kinetic energy storage system coupled to the bi-directional electrical bus and a controller. The controller is configured to communicate with the kinetic energy storage system and the power source. Wherein the controller is configured to operate the kinetic energy storage system as a primary power source for the bi-directional electrical bus and to operate the power source as a secondary power source for the bi-directional electrical bus when the kinetic energy storage system cannot satisfy an energy demand on the bi-directional electrical bus.
US10377223B2
A working machine that includes an internal combustion engine, a generator, an energy storage and an electric motor for driving one or more wheels of the working machine is provided. The internal combustion engine is arranged to drive the generator and the generator is arranged to supply power to the electric motor via the energy storage. The working machine further includes an accelerator for controlling the electric motor, and a hydraulic pump for driving a hydraulic actuator. The hydraulic pump has a drive source different from the electric motor and the accelerator is arranged for controlling the speed of the hydraulic pump.
US10377222B2
A drive device for a motor vehicle, comprising a first drive assembly, a second drive assembly, and an epicyclic gear train coupled to the second drive assembly, wherein the second drive assembly can be coupled to a driven shaft of the drive device via the epicyclic gear train and to the first drive assembly by means of a shift clutch. It is hereby provided that a secondary drive shaft of an at least one secondary drive of the drive device having a secondary assembly is coupled to the epicyclic gear train. The invention further relates to a method for operating a drive device for a motor vehicle.
US10377215B2
A tailgate cover includes at least one pocket to securely fit over a tailgate. In some embodiments, the tailgate cover includes two or three pockets. The tailgate cover is made of stretchable material such as a stretchable fabric which enables the cover to be stretched securely over the tailgate. To further secure the tailgate cover over the tailgate, any coupling device is able to be used. The tailgate cover is able to include any graphic and/or text.
US10377206B2
An apparatus is provided for removing gas from a vehicle storage unit. The apparatus includes at least one memory and a processor(s) detecting air being drawn, via an exhaust unit, from the front of a vehicle storage space to a rear of the vehicle storage space and through a ventilation unit forcing the air including emitted gas(es) to exit a top of the ventilation unit. The air is initially directed, from a supply unit in an upper part of the ventilation unit, into the rear of the vehicle storage space to the front of the vehicle storage space. The items emitted the gas. The computer program code may further cause the apparatus to measure the gas as the air passes through the ventilation unit to determine whether the measured gas equals or is below a predetermined threshold. Corresponding computer program products and methods are also provided.
US10377202B2
A suspension device for a vehicle includes a spring device disposed between a sprung member and an unsprung member of a vehicle and allowing a relative displacement between the sprung member and the unsprung member. The spring constant k2c of the spring device when the spring device is deformed in the direction in which the spring device contracts with respect to the predetermined reference length is configured to be smaller than the spring constant k2e of the spring device when the spring device is deformed in the direction in which the spring device expands with respect to the predetermined reference length. Consequently, it is possible to obtain a characteristic opposite to the spring characteristic of the seat, and as a result, ride quality can be improved.
US10377201B2
An elastomer coupling for an electromechanical actuator, having a drive part and a driven part, wherein either the drive part or the driven part has multiple radially outwardly extending webs arranged so as to be distributed about an axis of rotation, and the respective other part has radially inwardly extending webs arranged on the inner side of a tubular body, wherein a radially inwardly and a radially outwardly extending web engage into one another and form a pocket in which there is received an elastic molded body produced from an elastomer, wherein, in at least one pocket, there is received a spring element which generates a pretensioning force, which spring element is attached either to an inwardly extending or to an outwardly extending web and is spring-loaded against an adjacent web.
US10377195B2
A pin box is provided having a removable and reversible hitch. The removable hitch has a kingpin end and a ball end. The pin box has a skid plate with an aperture with a receiver that can receive and affix the removable hitch. The skid plate is reinforced to the receiver to carry the load when the ball end of the removable hitch is being used. A pin is slidable between a locked position where the removable hitch is retained and an unlocked position where the removable hitch is removable. The pin extends through an aperture in the removable hitch to affix the removable hitch to the pin box.
US10377188B2
A tire pressure regulating device for adjusting, while driving, the tire pressures of vehicle wheels of a plurality of vehicle axles of a motor vehicle with pneumatic tires includes at least one switchover valve arranged on the vehicle chassis that can be controlled in an electromagnetic/pneumatic manner, a plurality of axle valves, each axle valve being arranged on the vehicle chassis for each vehicle axle and being controllable in an electromagnetic/pneumatic manner, a plurality of pressure-controlled wheel valves, each pressure-controlled wheel valve being arranged at a respective vehicle wheel, a pilot control valve arranged on the vehicle chassis and being controllable in a purely electromagnetic manner or in an electromagnetic/pneumatic manner, and a plurality of two-channel rotary couplings arranged between the vehicle axles and associated vehicle wheels and provided with switchable seals.
US10377184B2
A pneumatic tire includes a tread portion provided with main grooves and land potions. The main grooves include an outboard shoulder main groove, an inboard shoulder main groove and a central main groove disposed therebetween. The land portions include an outboard central land portion and an inboard central land portion. The outboard central land portion is provided with first central sipes with a width of less than 2 mm, and is not provided with any grooves with a width equal to or more than 2 mm. The inboard central land portion is provided with second central sipes with a width of less than 2 mm, and is not provided with any grooves with a width equal to or more than 2 mm. The inboard central land portion is greater than the outboard central land portion in axial width.
US10377183B2
The tread includes over at least a first axial part (M) at least one wavy groove in a first direction and wavy grooves in a second direction. The wavy grooves in the second direction are connected to the wavy groove in the first direction. Over at least a second axial part (B) of the tread, at least one wavy groove continuous in a third direction, and wavy grooves continue in a fourth direction. The wavy grooves in the fourth direction are connected to the wavy groove in the third direction. When new, the open parts of the first axial part (M) are connected to one another, and the open parts of the second axial part (B) are not connected with one another. Beyond a part-wear condition, the open parts of the second axial part (B) are connected to one another, and the open parts of the first axial part (M) are not connected with one another.
US10377181B2
In a pneumatic tire, a tread rubber includes a recessed portion extending along a tire-circumferential direction, the recessed portion being placed at a position of a tire-outer surface superposed on an end of the belt portion or at a position of a tire-outer surface on an outer side in a tire-width direction than the former position of the tire-outer surface, an outer wound-up portion is placed closer to a belt portion than an inner wound-up portion, the outer wound-up portion is separated from the belt portion to prevent the outer wound-up portion from being superposed on the belt portion, and the outer wound-up portion is superposed on the recessed portion.
US10377180B2
The reinforcing element (34) has a cross-section with a flattened overall shape having an aspect ratio greater than or equal to 5 and extending in a main direction (Z1). It comprises a lateral edge (46) made of a polymeric composition comprising a thermoplastic polymer, the lateral edge (46) extending in a general direction substantially parallel to the main direction. The reinforcing element (34) is such that R=(Uc−U1)/Uc>11%, where Uc is the average value of the microhardness of the reinforcing element (34) measured in its central part, and U1 is the average value of the microhardness of the reinforcing element (34) measured at its lateral edge (36). The lateral edge (46) does not have any ridges.
US10377179B2
A pneumatic tire (1), wherein an inter-cord distance (Gcl) between a circumferential reinforcing layer (145) and an inner-side belt ply (142) at a tire equatorial plane (CL), an inter-cord distance (Gcu) between the circumferential reinforcing layer (145) and an outer-side belt ply (143) at the tire equatorial plane (CL), an inter-cord distance (Gsl) between the circumferential reinforcing layer (145) and the inner-side belt ply (142) at end regions of the circumferential reinforcing layer (145), an inter-cord distance (Gsu) between the circumferential reinforcing layer (145) and the outer-side belt ply (143) at the end regions of the circumferential reinforcing layer (145) have a relationship such that 1.20≤(Gcl+Gcu)/(Gsl+Gsu)≤9.20.
US10377169B2
Disclosed herein are an exterior forming method and an exterior forming structure of an electronic component. The exterior forming method of an electronic component may include mounting an injection-molded product, which is injection molded as an electronic component, to an upper portion a heat transferring base unit, mounting a printing film having an ink layer for a heat transfer to the upper portion of the heat transferring base unit such that the ink layer faces an upper surface of the injection-molded product, and heat-transferring the ink layer on the upper surface of the injection-molded product by rotating a heating roll while closely attached at an upper portion of the printing film. The exterior forming method may also include forming an UV coating layer on an upper portion of the ink layer that is heat-transferred on the injection-molded product.
US10377166B2
A knock type pen including a housing, a lead which is received in the housing and has an end to which a nib is coupled, and a knock element which protrudes from top of the housing and is pushed, a regulating element which is rotatably installed on an outer circumference of the housing, and a locking element which is provided in the housing and moves up and down by rotation of the regulating element, wherein when the locking element moves up, a press of the knock element is limited by the locking element.
US10377161B2
In certain examples described herein, a depositing mechanism performs an overcoat depositing operation. The depositing mechanism comprises a plurality of print head arrays. Each print head array is arrangeable in a deposit position to deposit an overcoat layer onto a substrate and a service position to enable servicing to be performed. In certain cases, an array controller causes at least one print head array of the plurality of print head arrays to be moved periodically from the deposit position to the service position according to a predefined servicing sequence during an ongoing overcoat depositing operation performed by the depositing mechanism.
US10377160B2
A method including printing a calibration pattern with a wide array printhead having a plurality of printhead dies. The method includes scanning the calibration pattern with a scanbar having a width less than a width of the wide array printhead by indexing the scanbar to a plurality of selected positions across a width of the calibration pattern and providing a scanned calibration image at each selected position, the calibration images together providing a scan of the full width of the calibration pattern, and measuring alignment between successive printhead dies based on the calibration images.
US10377141B2
A fixing device, an inkjet cartridge and an inkjet printing apparatus are disclosed. The fixing device includes a case body. The case body includes a front end and a rear end and provided with at least one groove extending from the rear end to the front end, the at least one groove is provided with at least one clamper therein for fixing a work piece therein.
US10377134B2
A MEMS device includes a wire that is formed of a conductive portion embedded into a recess opened in a first face of a substrate and a bump electrode that is electrically connected to the wire. A total width, in a second direction intersecting a first direction along which the wire extends on the first face, of an opening of the recess in a connection region where the wire and the bump electrode are electrically connected to each other is narrower than a width, in the second direction, of an opening of the recess in a region outside the connection region.
US10377130B2
According to an example, in a method for mitigating damage to a plurality of drop generators in a printing system, data corresponding to an image to be printed on a media by the printing system may be accessed. In addition, the plurality of drop generators may be controlled to print the image on the media while mitigating damage to the plurality of drop generators and without shifting placement of the image on the media or shifting the plurality of drop generators in a direction perpendicular to a feed direction of the media.
US10377118B2
Methods of preparing laminate test samples for subsequent testing, including positioning the test sample within a fixture body, securing the test sample within the fixture body, applying a separating force to urge a first layer portion of the test sample away from a second layer portion of the test sample, and separating the first layer portion from the second layer portion to create a predetermined separation length along the test sample, provided that the predetermined separation length is established by an interaction between the fixture body and the test sample as the first layer portion is separating from the second layer portion.
US10377110B2
A copper-clad laminate is prepared by laminating a copper foil on one side or both sides of a polyimide film by thermocompression bonding. The flexibility of the copper-clad laminate is remarkably improved by employing a polyimide film having a thickness of 5 to 20 μm and a copper foil having a thickness of 1 to 18 μm.
US10377107B2
An object of the present invention is to provide a structure body, which allows the obtaining of superior impact performance while suppressing increases in thickness and weight of a plastic plate and reducing cost, and a method for manufacturing that structure body. Provided is a structure body (1) provided with a structure (10) made of a metal or a thermosetting resin, a plastic plate (14) attached to a surface (10a) of the structure (10) with double-sided tape (12), and a non-foamed plastic sheet (A) having a glass transition temperature of −20° C. or lower arranged between the structure (10) and the plastic plate (14). Also provided is a method for manufacturing the structure body (1) that includes arranging the plastic sheet (A) between the structure (10) and the plastic plate (14) when attaching the plastic plate (14) to the surface (10a) of the structure (10) with the double-side tape (12).
US10377106B2
A 3D object according to the invention involves substrate layers infiltrated by a hardened material. The 3D object may be fabricated by a method comprising the following steps: Flatten a substrate layer. Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion. Flattening a substrate layer involves reducing planar inconsistencies or imperfections, and comprises applying heat to each substrate layer, cooling the substrate layers, and optionally applying tension and/or pressure to the heated and cooled substrate layers.
US10377100B2
Invention is a cleaning robot for cleaning the inner surfaces (5) of the half mold (4) of tire curing molds comprising a basket (10) wherein a lifting arm (50) placed in a manner pivotal on a proximal end (52), the lifting arm (50) pivoted on a distal end (54) of a support arm (70). The cleaning robot fits completely into the basket (10) when the positioned as close and comprising a movable head (80) having a nozzle (82) coupled in a manner to establish fluid communication to the dry ice inlet (84) and located at the distal end (76) of the support arm (70) and a free end which is configured movably closer to the inner surface (5) such as at a vicinity of the inner surface (5) along the contour of its when the positioned as open.
US10377098B2
A methods of executing start, run, and stop sequences on a machine for converting a web of preformed pouches into inflated dunnage units. The pouches are defined by transverse seals extending from a remote edge to within a predetermined distance from an inflation edge.
US10377092B2
Systems and methods are provided for verifying the placement of tows by a robot. One embodiment includes a robot that includes an end effector that lays up tows, actuators that reposition the end effector, a memory storing a Numerical Control (NC) program, and a robot controller that directs the actuators to reposition the end effector based on the NC program, and instructs the end effector to lay up tows based on the NC program. The system also includes a sensor system comprising an imaging device that acquires images of the tows as the tows are laid-up, a measuring device that generates input as tows are laid-up by the end effector, and a sensor controller that receives images from the imaging device and the input from the measuring device, and updates stored data to correlate the images with instructions in the NC program, based on the input.
US10377089B2
In order to provide a bonded part capable of reducing deformation caused by injection pressure of bonding resin and preventing an increase in cost, the bonded part includes a first part, a second part, and a third part, wherein the first part includes a wall portion and a hollow portion surrounded by the wall portion, wherein a first shape portion formed of bonding resin is arranged at a position between the second part and the wall portion, wherein a second shape portion formed of the bonding resin is arranged at a position between the wall portion and the third part, and wherein a third shape portion formed of the bonding resin which connects the first shape portion and the second shape portion is arranged on the wall portion.
US10377088B2
A device for liquid-tight sealing of two partially overlapping packaging components. One of these is a tubular basic body. A further packaging component forms the packaging head or bottom, having at least one mandrel and one die. For the tubular basic body to be easily slid on to the mandrel and removed the expansion elements have sealing jaws which, in their working position, form a closed, encircling outer contour.
US10377081B2
A method is described in which data representing a three-dimensional object to be printed is obtained. The data comprises object property data indicative of properties of the three-dimensional object. Layers within the three-dimensional object to be printed are identified. The obtained data is processed by comparing object property data associated with an identified layer to object property data associated with a reference layer selected from the identified layers. Where a difference in object property data associated with an identified layer and object property data associated with a reference layer is determined, the determined difference is stored.
US10377072B2
An apparatus for taking out a molded product that is capable of suppressing displacement vibration of an attachment in a shorter time than ever without using a large-scaled electric actuator. An active controller starts active control after the amplitude of displacement vibration of the take-out head as an attachment has been attenuated to a predetermined setting by means of positioning control by a servomotor or when the amplitude can be considered as having been attenuated to the predetermined setting. The positioning control is first performed by the servomotor, and then the active control is performed by the active controller using an electric actuator which is light in weight and small in size.
US10377069B2
An injection molded part for a motor vehicle includes a film having a scratch-resistant layer, a plastic substrate molded to the film, wherein the plastic substrate is at least partially transparent or translucent, and a scratch-resistant coating molded to the plastic substrate on a side opposite the film.
US10377063B1
A production line for manufacturing molded columns comprises a plurality of molding machines, a carousel to convey the molding machines along a closed path, a pouring station disposed adjacent the closed path, and an unloading station disposed adjacent the closed path generally opposite the pouring station. A molding material is poured into molds in the molding machines as the molding machines are conveyed past the pouring station. The molding machines are actuated as the molding machines are being conveyed from the pouring station to the unloading station. At the unloading station, the molding machines are stopped and the molds are unloaded from the molding machines. The unloading station may include extraction equipment to extract the molded columns from the molds.
US10377062B2
The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
US10377059B2
An apparatus for taking out a molded product that is capable of suppressing displacement vibration of an attachment in a shorter time than ever without using a large-scaled electric actuator. An active controller performs active control in conjunction with the positioning, control by the servomotor. At the beginning of the active control, the positioning control is primarily performed by the servomotor, and then the active control is positively performed by the active controller using an electric actuator. Compared with when only the active control is performed for vibration suppression, a lighter and smaller electric actuator can be employed.
US10377051B2
A shaving blade cartridge includes a housing having first and second longitudinal sides extending between top and bottom sides. A primary cutting blade is mounted on the housing and has a cutting edge. A primary cap is located rearward of the cutting edge. A trimming element includes a trimming edge, the trimming edge and the cutting edge being opposite. A trimming guard bar includes a trimming guard bar edge. The trimming edge, the trimming guard bar edge, and a tangent to the trimming guard bar in the vicinity of the trimming guard bar edge define a theoretical limit trimming curve which is concave when viewed in relation to the trimming guard bar. The trimming guard bar is disposed behind and/or tangential to the theoretical limit trimming curve toward the second longitudinal side, such that the trimming guard bar does not project beyond the theoretical limit trimming curve.
US10377050B2
The present disclosure relates to a method of forming a sheet-metal based double-walled stationary blade (24) for a hair cutting appliance (10), the method comprising: providing a first pre-product layer (70), providing a second pre-product layer (72) which is separate from the first pre-product layer (70), providing a guide slot (44) for a cutter (26), and bonding the first pre-product layer (70) and the second pre-product layer (72) to one another such that the pre-product layers (70, 72) are arranged to jointly receive a to-be-mounted cutter (26), wherein the first pre-product layer (70) and the second pre-product layer (72), in the bonded state, are at least partially offset from one another to provide a defined mating clearance fit for the to-be-mounted cutter (26), wherein the pre-product layers (70, 72) are bonded to one another at their longitudinal ends such that stationary blade teeth (54) are partially formed by the first pre-product layer (70) and partially formed by the second pre-product layer (72), and wherein tips (56) of the stationary blade teeth (54) are arranged adjacent to a transition zone (84) between the pre-product layers (70, 72). The present disclosure further relates to a cutting appliance and to a blade set (22) for such an appliance.
US10377048B2
An adjustment drive is provided for an adjustable spacing comb for a hair cutting appliance. The adjustment drive includes an actuator, a sensor element and a control unit. The actuator actuates a movable comb portion of the adjustable spacing comb with respect to a blade set of the hair cutting appliance. The sensor element detects multi-faceted user inputs applied to the sensor element by a user and to output a user input signal that is derived from the multi-faceted user inputs. The actuator is operated on the basis of the user input signal. The control unit is coupled to the actuator and to the sensor element, and converts the user input signal into an actuator operating signal. The multi-faceted user inputs include detected user input speed of an input stroke by the user.
US10377033B2
A tool tethering method includes the steps of providing a tool with a longitudinal portion, installing a base layer on the longitudinal portion, and providing a connector strap assembly. The connector strap assembly includes a closed-loop connector, a length of tubing, and a length of stretchable webbing secured to a connector and extending through the shrink tubing. A base layer is installed on the longitudinal portion of the tool. The length of stretchable webbing is aligned to extend along the base layer and the longitudinal portion is inserted into the tubing and substantially centered on the base layer. The tubing is caused to assume the reduced state to provide a snug fit on the hand tool, stretchable webbing, and base layer.
US10377030B2
A tool handle for holding multiple tools of different sizes during use. A wedge and body which, when placed together, creates a handle with a generally cylindrical shape and internal cavities for retaining hexagonal wrenches. A sliding wedge holds the hexagonal wrench and itself into place. A plurality of slots that allow each size tool to be indexed to the underside of the sliding member/wedge. There are two grouping arrangement of tools within the handle: a large group and a small group facing the opposite direction. The purpose for the two groups is to optimize the function of the wedge. If all of the tools were oriented in the same main slot then the smallest tools would not protrude from the end of the handle/body in a screwdriver mode to facilitate good function. Therefore the two groupings are arranged back to back to stabilize the tools laterally.
US10377018B2
A sheet of coarse sandpaper includes a backing layer having opposed first and second major surfaces, an adhesive make coat on the second major surface, coarse abrasive particles at least partially embedded in the make coat, thereby defining a coarse abrasive surface, and an exposed non-slip coating layer on the first major surface. Methods of making and using such coarse sandpaper are also provided.
US10377016B2
An abrasive article comprising: a first body comprising a first bond material having abrasive particles contained within the first bond material, wherein the first body comprising the first bond material comprises a ratio of VAG(1)/VBM(1) of at least about 1.3; a second body comprising a second bond material having abrasive particles contained within the second bond material, wherein the second body comprising the second bond material comprises a ratio of VAG(2)/VBM(2) of less than about 1.3, and wherein VAG is a volume percent of abrasive particles within a total volume of the first or second body respectively and VBM is a volume percent of the first or second bond material within the total volume of the first or second body respectively.
US10377013B2
Some embodiments relate to a method of using a polishing system. In this method, a wafer is secured in a carrier head. The carrier head includes a housing, which includes a retaining ring recess, enclosing the wafer. A retaining ring is positioned in the retaining ring recess. The retaining ring surrounds the wafer, and has a hardness ranging from about 5 shore A to about 80 shore D. The wafer is pressed against a polishing pad, and at least one of the carrier head or the polishing pad is moved relative to the other.
US10377012B2
A method for manufacturing an angle-type air tool housing is provided. The angle-type air tool housing includes a hollow tube having a first end and a second end that are open and are mutually in communication, and an overall housing formed by injection molding and enveloping the hollow tube, and having an accommodating chamber adjacent to the first end, an air channel adjacent to the second end and in communication with the accommodating chamber through the hollow tube, and a pair of recesses exposing a part of the hollow tube. Accordingly, the angle-type air tool housing that is a formed integral with the hollow tube is formed so as to achieve effects of reduced costs and weight.
US10377010B2
A machine tool of the present invention includes: a visual sensor that takes an image of unworked workpiece; an unworked workpiece shape information storing unit that stores unworked workpiece shape information obtained by the visual sensor; a worked workpiece shape information storing unit in which worked workpiece shape information is stored; a burr information calculating unit that recognizes a burr by comparing the unworked workpiece shape information with the worked workpiece shape information; a burr determining unit that determines the burr based on conditions including at least one of the location and the direction of the burr in the workpiece; a working method judging unit that decides whether or not to perform burring with a tool of the machine tool based on the determination result concerning the burr; and a working path generating unit that generates a working path for removing the burr judged to be a burr on which burring is to be performed with the tool.
US10377009B2
A machine tool is configured so that a working area in which a workpiece is worked using a tool can be monitored, and includes a cover that is provided to cover the working area, and isolates the inside of the machine tool that includes the working area from the outside, at least one camera that is provided to the inner side of the cover, and captures the inside of the machine tool, and a touch panel that is provided to the cover, wherein the touch panel includes a display panel and an input operation panel, and the display panel displays an image of the inside of the machine tool that has been captured by the at least one camera.
US10377000B2
An accessory device suitable for use with an electronic device is disclosed and may be designed to provide a protective cover and dissipate heat from the device. Regarding the latter, the accessory device may include a thermally conductive layer disposed in the accessory device. The thermally conductive layer may extend from a first end of the accessory device proximate to a heat-generating component in the electronic device, to a second end away from the heat-generating component. The thermally conductive layer is designed to navigate heat away from the heat-generating component to the second end where the heat escapes the accessory device. The second end may include one or more openings to facilitate heat transfer from the accessory device. In other embodiments, the accessory device includes a phase change material that absorbs heat and changes to a liquid, then passes the heat to another location in the accessory device.
US10376993B2
A manifold assembly for an automobile cooling system includes a crossover tube and a crossover tube cover welded in an opening of the crossover tube A flash trap is provided adjacent the region of the weld joint to receive and capture weld flash migrating inwardly in the crossover tube.
US10376990B2
An induction heating coil includes a coil section configured to heat a treatment target by induction, a power supply section configured to supply power to the coil section, and a cooling medium passage that is arranged in the power supply section and the coil section, and is configured to supply a cooling medium to the coil section. The coil section, the power supply section, and the cooling medium passage are formed using a metal additive fabrication method.
US10376972B2
Provided are a porous media bearing for a band saw, a band saw for cutting cant and a method of cutting cant using the band saw. The band saw has a continuous loop blade supported by a drive wheel and first and second support arms having porous media bearings. A location of a blade cutting section, an angle of the blade in relation to the cant being cut, and tension on the blade can be adjusted by moving the first and second support arms.
US10376966B2
A chuck for a power tool includes a chuck body extending along a longitudinal axis. The chuck also includes a plurality of jaws, each with a jaw end, and each movable along a respective jaw axis between a closed position and an open position. Each respective jaw axis is oriented at an oblique angle relative to the longitudinal axis. A biasing member is coupled to the jaws and is operable to bias the jaws toward the closed position. The biasing member includes a spring. The chuck also includes a rotating assembly selectively engageable with the jaws such that, when engaged, the jaws are movable in response to rotation of the rotating assembly. The biasing member includes a guide sleeve coupled to each of the jaws and movable axially along the longitudinal axis in response to each of the jaws moving along its respective jaw axis.
US10376963B2
A pipe end machining device configured to machine an end of a pipe includes an outer housing having a spindle rotatably mounted therein, tool carriers are mounted on the spindle, a hub assembly attached to the outer housing, a vertical adjustment assembly attached to the hub assembly and to the outer housing, and a drive assembly configured to rotate the spindle and tool carriers. The vertical adjustment assembly adjusts the upward and downward position of the cutting tools relative to the pipe. The hub assembly mounts the device to the pipe and fixes the relative upward or downward position of the cutting tools relative to the pipe, thereby preventing vibration and chatter when the device is cutting a planar surface on the end of the pipe.
US10376958B2
Aspects of the disclosure include a removable support for additive manufacture and methods and code for manufacturing and removing the same. A removable support for a laser-sintered component having at least one surface to connect to may include a support body, a first set of connectors, and a second set of connectors. The support body may have a first wing and a second wing, each with a distal surface and a lateral midline bisecting the distal surface. Each set of connectors may project from the distal surface on one side of the lateral midline of their respective wings to connect to the surface of the component while the distal surface also defines a connector-free portion on the other side of the lateral midline.
US10376940B2
A method of cleaning can bodies having a continuous sidewall closed at one end by an integral bottom portion opposite an open end is described. A can body transporter is populated a plurality of can bodies. The transporter transfers can bodies through a can body washer apparatus from an entry end to a delivery end. A plurality of spray bars are located between the entry end and the delivery end and delivers a washing solution to the plurality of can bodies. A substantially constant can body population density is maintained on the can body transporter by controlling a speed of the can body transporter relative to a rate of production of can bodies produced by an upstream can body making apparatus. A time duration of an exposure of the plurality of can bodies to the solution is controlled by regulating delivery of the solution.
US10376939B2
The invention relates to a tool unit (12) for an extrusion machine (1) with a scraping element (51), a tool element (49) with an expanding channel (50) receiving the scraped extrusion material (3) and a die (53). The tool unit (12) includes a receiving cage (42) with first and second receiving cage parts (43, 44). In the first receiving cage part (43) there is a tool element (49) inserted in a receiving channel (48). In the second receiving cage part (44) a receiving chamber (52) facing the first receiving cage part (43) is formed, in which at least the die (53) is received and supported by a support surface (56). In the tool element (49) as well as in the first receiving cage part (43) a common receiving groove (62) is formed with at least one groove base surface (63, 64), in which the scraping element (51) is inserted loosely and is supported. The invention also relates to an extrusion machine (1) as well as to a method for changing the friction wheel (4).
US10376929B2
An apparatus which can polish an entirety of a surface of a substrate, such as a wafer, is disclosed. The apparatus includes a substrate holder configured to hold a substrate and rotate the substrate; and a polishing head configured to rub a polishing tool against a first surface of the substrate to polish the first surface. The substrate holder includes a plurality of rollers which can contact a periphery of the substrate. The plurality of rollers are rotatable about their respective own axes.
US10376926B2
An inspection and sorting system sorts conveyed articles. The system is provided with a conveyance device, an X-ray inspection device, and a sorting device. The conveyance device conveys inspection articles. The X-ray inspection device inspects the conveyed inspection articles. The sorting device has an air sorting mechanism that sorts the conveyed inspection articles in a sorting operation. The sorting device has a sorting information receiving component, a reference signal receiving component, and a sorting mechanism control component. The sorting information receiving component receives sorting information relating to the sorting of the inspection articles based on an inspection result of the X-ray inspection device. The reference signal receiving component receives a fixed-interval reference signal relating to the conveyance by the conveyance device. The sorting mechanism control component controls the air sorting mechanism to execute the sorting operation based on the sorting information at a timing adjusted by the reference signal.
US10376925B2
For sorting silkworm chrysalises, a feed mechanism positions silkworm chrysalises on a delivery mechanism. The delivery mechanism receives and carries the silkworm chrysalises from the feed mechanism. A detection mechanism detects a female silkworm chrysalis based on an optical wavelength emitted by the female silkworm chrysalis. A sorting mechanism that sorts the silkworm chrysalises, putting female silkworm chrysalises into a female collecting box, and male silkworm chrysalises into male collecting box.
US10376914B2
A product applicator system for distributing a liquid product accurately using low volume applications which minimize the quantity of product used and ensures more accurate results. The product applicator system generally includes a housing which includes a removable inlet port mount and outlet port mount. The positioning of the inlet and outlet port mounts on the housing is interchangeable. Supply hoses provide a product to the inlet port mount where the product is traversed through internal conduits to exit the housing via oscillating and overlapping spray heads. An internal motor provides oscillating motion to the spray heads. A rotator assembly which includes a rotator motor may be utilized to orient the housing in horizontal, vertical, or various diagonal orientations. The housing is adapted to either connect to a vehicle, be positioned on a stationary or movable platform, or be connected to a boom using boom connectors.
US10376913B2
A system for spraying a coating such as lacquer on the internal surface of a can body (2) comprising vacuum chuck gears (42) for each vacuum chuck (16). The vacuum chucks hold the can body as it rotates about a main process turret (10) and to a spray station (32, 34). A ring gear rotates independently of main turret rotation and further gearing connects the ring gear to a vacuum chuck drive motor (11). The spray system provides tight process control and allows flexibility of process revolutions or use of higher machine production speed.
US10376891B2
The present invention relates to systems and methods of temperature referencing for melt curve data collection. More specifically, the present invention relates to systems and methods for collecting DNA melt curve data for a DNA sample and a temperature reference material.
US10376890B2
The disclosed apparatus, systems and methods relate to a modular microfluidic device, the component comprising a channel comprising an apex opening, wherein the apex opening that is at least partially surrounded by a collar configured to pin a liquid within the channel. The modular microfluidic device may also have a structural tip in or near the apex opening which is configured to allow for the flow of the liquid into the channel from a second component for a modular microfluidic device when the component is engaged with the second component.
US10376885B2
Disclosed herein are apparatuses comprising, for example, a microfluidic channel device comprising a main body comprising a channel configured to provide for helical fluid motion of material within the channel; and a temperature control system that applies a temperature gradient to the channel. Methods of making and using the apparatus are also described.
US10376880B2
A lateral flow assay test device providing a structure for the lateral flow assay reactions provides for a continuous flow path of bibulous material provided in separate but contiguous regions of the device in which the bibulous layers are in fluid contact with each other thereby providing flow control of the timing and speed of the assay reaction. Increased flow control results in increasing reliability of use, increasing sophistication of reactions and increases the range of molecules or diagnosis that can be identified. Such flow control can extend processing times and allow users or test givers to manually delay test processing providing enhanced test results.
US10376878B2
Method for the treatment of a biological sample comprising at least one cell and a liquid component; according to the method, a force is applied to the sample inserted in an inner chamber of a hollow device towards a filter which has pores with diameters from 2 nm to 1 μm, so that at least part of the liquid component passes through the filter and the cell remains in the inner chamber, thus obtaining a concentrated sample; the filter has a surface facing the inner chamber of less than 12.6 mm2.
US10376876B2
A pipette is described having a tube, a pressure mechanism, and at least one reagent pad. The tube has a first end, a second end opposite the first end, and a sidewall extending between the first end and the second end, with the sidewall defining an interior cavity. The pressure mechanism is operably connected to the first end of the tube and is configured to enable a sample to be drawn into the interior cavity of the tube through the second end of the tube. The at least one reagent pad is positioned in the interior cavity of the tube and within a predefined liquid path whereby the sample contacts at least a portion of the at least one reagent pad when drawn into the interior cavity. In another embodiment, a pipette is described having a tube, a pressure mechanism, and a capillary positioned within the tube.
US10376872B2
Catalyst systems that are resistant to high-temperature sintering and methods for preparing such catalyst systems that are resistant to sintering at high temperatures are provided. Methods of forming such catalyst systems include contacting a support having a surface including a catalyst particle with a solution comprising a metal salt and having an acidic pH. The metal salt is precipitated onto the surface of the support. Next, the metal salt is calcined to selectively generate a porous coating of metal oxide on the surface of the support distributed around the catalyst particle.
US10376861B2
The present disclosure pertains to methods of capturing CO2 from an environment at pressures above 1 bar by associating the environment with a porous material that has a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm. The present disclosure also pertains to methods for the separation of CO2 from natural gas in an environment at partial pressures of either component above 1 bar by associating the environment with a porous material that has a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm.
US10376858B2
The present invention relates to a method of producing an oligomer array. The invention comprises the steps of: providing a substrate with a multitude of recesses; introducing a first particle with a first molecule into a recess; releasing the first molecule from the first particle; binding the first molecule to a second molecule to form an oligomer while immobilizing the second molecule in the recess; optionally repeating the steps, wherein at least one of the first particles and/or the first molecules comprises a detectable marker.
US10376857B1
Methods and apparatuses for controlling the size of microbubbles are provided herein. The methods include forming a microbubble in a liquid at an inlet end of a liquid microchannel, the liquid microchannel having an outlet end spaced from the inlet end and a liquid microchannel conduit extending therebetween. As the liquid is propelled along a length of the liquid microchannel, the liquid carry the microbubble, a negative pressure is applied to a first very low pressure microchannel having a first end, a second end spaced from the first end and a first very low pressure microchannel conduit extending between the first end and the second end and having a portion thereof being laterally spaced from and adjacent to a portion of the liquid microchannel conduit. The negative pressure withdraws air from the microbubble in the liquid microchannel to shrink the microbubble as the microbubble travels along the portion of the liquid microchannel conduit.
US10376811B2
A cold trap has multiple interior spaces formed within one unit such that a vacuum pump pulls only dry air and distillate substantially fully or fully condenses and drops out of the bottom of the device. Laminar flow through a side portal is converted into turbulent flow in a cooling region around a conical cold glass or other inert protrusion. The only other portal of the cooling region is a bottom portal such that though there is vacuum suction, vapors only exit through the bottom portal after condensing and falling through an outer section while dry air is pulled upwards to an upper vacuum portal.
US10376807B2
An apparatus for generating purified liquid from an input liquid, comprises, an evaporation chamber flooded with the input liquid and wherein the evaporation chamber generates saturated gases and comprises a shared wall with the condensation chamber and wherein the evaporation chamber is configured to generate evaporation cavities and condensation cavities on respective sides of the shared wall for a 2-phase counter flow of a liquid phase component and a gaseous phase component in composite flows for a 2-phase to 2-phase direct latent heat exchange. A condensation chamber has channels disposed in the input liquid, wherein liquid-saturated gases are generated therefrom in the evaporation chamber. The apparatus is operated as a four-port counter-flow heat exchanger where two different fluids are exchanging heat based on the inlet ports of both fluids being on opposite sides and the outlet ports of both fluids are also on opposite sides of the evaporator and condenser.
US10376801B1
A magnetic tracked toy assembly for entertainment includes a panel, which is annular, and plurality of shells. A plurality of rails is coupled to an upper surface of the panel so that the rails extend annularly and in parallel around the panel. A respective groove, which is complementary to the rails, is positioned in a bottom of a respective shell so that the groove is positioned to selectively insert a respective rail. Each shell is coupled to a respective blower module, which in turn is coupled to a respective controller. The panel, the rails and the shells are magnetized so that each shell is repelled by the panel and the respective rail to levitate the shell above the panel. The controller is positioned to command the blower module to selectively expel air to propel the respective shell along the panel with the respective rail positioned to guide the respective shell.
US10376799B2
A water attraction having one or more inflatable areas and/or features for reducing turbulence of water flow over a ride surface is disclosed. The water attraction includes a ride surface, a water delivery section, and a recovery section. The water delivery section provides water flow on the ride surface. The ride surface may include the assembly of multiple segments and may be fully or partially inflatable. The water delivery section may include one or more water delivery mechanisms, for example, nozzles. A water delivery mechanism may deliver a water flow different from the water flows from other water delivery mechanisms. In one embodiment, the water delivery section includes water delivery mechanisms directed in a fanned-out configuration in order to reduce turbulence. In another embodiment, gaps between segments of the ride surface may provide a “buffer” for overlapping water flow in order to achieve a smooth water surface.
US10376791B1
A system and methodology for executing a trivia contest/tournament simultaneously to a plurality of electronic devices, while eliminating fraud associated with trivia contests by ensuring that every gameplay experience across multiple devices, regardless of location, is consistent. This is accomplished by onboarding an electronic device, receiving a current date and time of the underlying user in a predetermined set of parameters, generating a payload (start time of contest, questions, order of questions, duration of each question, termination time of contest, etc.) and transmitting it to the electronic device at a time before the start of the contest. The lag time between all electronic devices is calculated and accounted for, so that each device starts the contest at the same time. The trivia contest takes place and terminates, so that each player has the same experience. Their answers are encrypted and transmitted back to the system for recording and assessment.
US10376784B2
Technologies are generally described for reducing lag time via predictive caching in cloud-based gaming. In one example, a cloud-based gaming system may identify game paths that can be taken during real-time game play and may break down the game paths into subsets of path segments a player can select. The system may determine a probability of the player taking a subset of the path segments based on real-time actions by the player and a game history of the current player and past players. The system may assign probabilities of being selected to the subsets of path segments and may render the subsets of path segments based on their respective probabilities. The system may transmit the rendered game content data for the subsets of path segments to a game client for caching on the local cache so that the game content data may be available when needed during real-time game play.
US10376778B2
Provided is an information processing system including at least a reflection member, and an information processing apparatus capable of image processing. The reflection member is a retro reflecting material. The information processing apparatus includes an imaging section that captures an image, a first light emitting section, a second light emitting section, and a light source detecting section. The first light emitting section and the second light emitting section each emit light. At least one of a half-power angle and an entrance angle of the second light emitting section is different from that of the first light emitting section. The light source detecting section detects, in the image captured by the imaging section, a light source image including an image of the retro reflecting material.
US10376776B2
A system and method for providing a video game using information stored by physical objects are disclosed. The video game may take place in a virtual space. Users may access the virtual space via client computing platforms. Users may participate in the video game by controlling game entities in the virtual space. Individual ones of the game entities may be associated with individual physical objects. The information stored by individual physical objects may be implemented by virtue of a client computing platform receiving the stored information. The information may be implemented independently from gameplay in the virtual space using the associated game entity. For example, a physical object may store information related to a “limited edition” version of an associated game entity that may only be implemented in the virtual space by virtue of the information being received from the physical object.
US10376770B2
A striking glove may comprise an inner glove, an outer shell, and at least one strap at least partially disposed within a dorsal cavity between the inner glove and the outer shell. A portion of the at least one strap disposed within the dorsal cavity may be configured in an overlapped and crossed configuration. The ends of the at least one strap may extend from the dorsal cavity to an exterior of the striking glove.
US10376761B2
A bat composed of composite materials is disclosed. Multiple layers of composite material is wound, weaved or interlaced around a mandrel to create a tubular structure composed of composite material. The tubular structure is cured and the mandrel is removed, leaving a hollow tubular structure. A composite material insert is inserted to the tip of the tubular structure, to seal the tubular structure. The knob portion of the structure is likewise sealed. The tubular structure is wrapped with fibrous material, such that the fibrous material encompasses the knob, body and tip of the structure. The resulting structure is a bat wherein the knob of the bat transitions to the barrel of the bat and the barrel of the bat transitions seamlessly to the tip of the bat, to create a continuous composite structure. This solid structure is then injection molded, with a solid bat tip and knob in place.
US10376757B2
A golf club head, including a weight system including an adjustable weight including an aperture, the aperture dimensioned to receive a fastener, a bore formed in the sole, a fastener configured to pass through the aperture of the adjustable weight and engage the bore, wherein rotation of the adjustable weight alters the location of the center of gravity of the body, wherein the adjustable weight comprises a first engaging arm and a second engaging arm, wherein the sole of the golf club head comprises a first engagement member and a second engagement member, the first and second engagement members adapted to engage any one of the engaging arms when the adjustable weight is in the locked position, the first and second engagement members preventing the adjustable weight from rotating relative to the body.
US10376755B2
A golf club head includes a striking face with a plurality of scorelines. A first virtual vertical plane is perpendicular to the striking face and passes through a toe-wardmost extent of the scorelines, and a second virtual vertical plane is parallel to the first virtual vertical plane and passes through a heel-wardmost extent of the scorelines. A central region bounded by the first virtual vertical plane, the second virtual vertical plane, and a striking face periphery has a first average surface roughness Ra1 of between about 40 μin and about 180 μin. And a majority of a toe region hounded by the first vertical plane and the striking face periphery is textured to have a second average surface roughness Ra2 no less than 1.5 times Ra1.
US10376747B2
Multi-layered golf balls having a core, intermediate layer, and cover are provided. The ball includes a non-foamed inner core (center) made of a thermoplastic or thermoset composition such as polybutadiene rubber. An intermediate layer comprising a foamed composition, such as polyurethane foam, is disposed about the inner core. The foamed intermediate layer may have a specific gravity gradient within the layer, wherein the outer surface specific gravity is greater than the midpoint specific gravity. Ball constructions having two intermediate layers, wherein at least one layer is a foamed layer can be made. A cover having at least one layer is disposed about the intermediate layer.
US10376744B1
A golf ball with a core comprising polybutadiene and graphene, and a soft cover is disclosed herein. The golf ball has a dual core with an outer core comprising polybutadiene and graphene. The soft cover is preferably composed of a highly neutralized polymer, a first ionomer, a second ionomer, and a paraloid impact modifier.
US10376735B2
A multi-functional rowing exerciser apparatus accommodates a plurality of rowing and paddling by connecting or releasing a cable system to selectively configure the rowing exerciser for sweep rowing, sculling oar rowing configuration to the Stand-Up-Paddling configuration in an easy and convenient manner.
US10376734B1
Gait analysis systems are provided with body support systems for user's self-adjustment of body weight force when ambulating with the body support systems. The gait analysis systems with the body support systems can be used with a treadmill or over a fixed surface for gait training and analysis with the ability to adjust the user's body weight force during the collection of gait data. Gait data for analysis is collected by an array of sensors mounted on the body support systems in various combinations for sensing gait movement, video imaging, heel strike and toe off states, video processing, feet pressure maps and electromyography.
US10376733B2
An exercise assembly for resistance exercises includes a base that is configured to position on a horizontal surface. A post is coupled to and extends perpendicularly from the base. A beam is rotationally coupled to and extends bidirectionally from the post. A first plate is coupled to and centrally positioned above the post. The first plate is padded and configured to seat a user. Each of a pair of rods is slidably coupled to and extends bidirectionally from the beam between the first plate and a respective opposing end of the beam. The rods are configured to selectively couple to the hands and feet of the user. A plurality of bands, which is resilient, is selectively couplable to and extends between the rods and the first plate. The bands are configured to selectively resist movement of the rods along the beam.
US10376731B2
A pedal drive system, in particular for an electric vehicle or a training apparatus, and for generating electrical power from muscle power of a user with at least one pedal and an electric generator, connected mechanically with said at least one pedal, is provided. To improve the haptic feel and feedback at the pedal, a control unit is provided for controlling a feedback torque, applied at said pedal, wherein the control unit comprises a haptic renderer, configured for control of said feedback torque based on at least one predefined pedal reference trajectory.
US10376729B2
An exercise device is provided that replicates on dry land the movement and resistance of a paddling motion. The exercise device includes a hollow upper shaft, a handle connected to an upper end of the upper shaft, and a lower shaft coupled at least partially within the upper shaft by a spring, to allow retraction into and extension from the upper shaft. The exercise device further includes a blade replacement assembly connected with a bottom end of the lower shaft, the blade replacement assembly comprising one or more wheels connected with a bottom end of the lower shaft and a resistance mechanism to provide resistance against a rolling direction of the one or more wheels.
US10376724B2
A protection device for a fire protection sprinkler having a first housing portion extending along a first housing axis defining a first internal housing chamber for receipt of one portion of a trigger assembly. A second housing portion of the protection device extends along a second housing axis and defines a second internal housing chamber for circumscribing a another portion of the trigger assembly. The first housing chamber is in communication with the second housing chamber.
US10376720B2
The present invention relates to a sealed and ventilated receptacle for storing equipment, such as firefighter turnout gear, that generally includes a base, at least one sidewall extending from the base, and a top wall that covers the opposite end of the sidewall. A sealable door may be positioned on the sidewall to access the inside of the receptacle and to prevent any contaminants from exiting the receptacle. The receptacle may also include an intake fan and exhaust fan that are each connected to a duct for providing fresh air to and removing contaminated air from the inside of the receptacle. The receptacle may further include a temperature control unit for regulating the temperature inside of the receptacle. Additionally, a hook for hanging a firefighter coat, trousers, or other items may also be included on the inside of the receptacle.
US10376719B1
Provided here is a multifunctional tool functioning as a mobile device holder, a safety hammer and a cutter for use in a car. Generally, the multifunctional tool body has a top cover containing magnet(s), a bottom cover, a striking assembly with a striking mechanism disposed between the top and bottom covers, a blade disposed on the outer surface of the body and a clip disposed on the bottom cover. The multifunctional tool is secured to a vehicle vent and can is used to break window glass and/or cut a seat belt in an emergency and to magnetically secure a mobile device for easy accessibility.
US10376716B2
Prior to the radiotherapy, an MR guided radiotherapy device acquires MR data and tracks structures relevant to the radiotherapy treatment. These MR data are displayed to a user. Furthermore, these data are used to calculate a quality factor for the treatment.
US10376713B2
A radiation therapy planning apparatus performs dose calculation at high speed and with high accuracy for radiation therapy in a scanning irradiation method. The apparatus includes a display, an arithmetic processing apparatus, a memory, and a data server, which is connected to a particle beam irradiation apparatus. A dose calculation unit of the arithmetic processing apparatus calculates dose distribution by a simplified Monte Carlo algorithm, and corrects the dose distribution by a decreasing rate stored in a particle number decreasing rate table of the memory, and stores the corrected dose distribution in an integrated dose distribution table. By using the simplified Monte Carlo algorithm and the particle number decreasing rate that corrects the simplified Monte Carlo algorithm, the dose distribution is calculated, and thereby, it is possible to realize a radiation therapy planning apparatus that performs dose calculation at a high speed with high accuracy.
US10376709B2
An apparatus for nuclear magnetic resonance therapy comprises a bed, two opposing sweep coils, as well as an upper coil and a lower coil for generating an alternating magnetic field.
US10376708B2
There is provided in accordance with an exemplary embodiment of the invention a method of osteointegration of an implant into surrounding jaw-bone, the method comprising: applying a magnetic field around an implant, the magnetic field produced around the implant to a jaw-bone depth of up to at least about 7 mm, the magnetic field having a magnetic flux density of about 0.05-0.5 mT at up to at least about 2 mm from a surface of the implant, the magnetic field produced by a coil within the implant. A device adapted for insertion into a jawbone implant and for producing the magnetic field for bone enhancement of surrounding jawbone is also described.
US10376696B2
Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
US10376694B2
The present invention provides methods of treating a gastrointestinal condition. In some embodiments, the method generally includes administering a chemical or electrical stimulus to an artery of the gastrointestinal vasculature of the subject, a vein of the gastrointestinal vasculature of the subject, a nerve supplying an artery of the gastrointestinal vasculature of the subject, and/or a nerve supplying a vein of the gastrointestinal vasculature of the subject, wherein the chemical or electrical stimulus is effective for treating a gastrointestinal condition.
US10376692B2
An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.
US10376686B2
The present invention relates to a cap for a medical connector. More specifically, the present invention related to an antimicrobial cap for placement over a connector, wherein various features of the antimicrobial cap maintain the connector in an antiseptic state.
US10376681B2
A compliance restoration device includes a compliance balloon lumen, a chamber support structure disposed in the compliance balloon lumen and configured to expand to support an expanded volume of the compliance balloon lumen, and a spring assembly configured to cause the chamber support structure to expand by applying a force on a first end of the chamber support structure.
US10376679B2
A medical balloon comprises a first end, a second end spaced apart from the first, and a generally cylindrical balloon wall extending therebetween to define an inflation chamber. The balloon wall is adapted for inflation from a first folded configuration having a first plurality of pleats to an expanded, unpleated configuration, and deflation therefrom to a second folded configuration having a second plurality of pleats. The balloon wall includes a first layer formed of a polymer and having a substantially constant radial thickness. A second layer is firmly attached to the first layer and has a plurality of first regions of greater radial thickness interleaved with a plurality of second regions of reduced radial thickness. During deflation from the expanded, unpleated configuration to the second folded configuration, the balloon wall folds along the regions of reduced radial thickness of the second layer to form the second plurality of pleats.
US10376678B2
A system for controlling reperfusion in a blood vessel of a patient including a flexible elongated member configured and dimensioned for insertion in the vessel of the patient, the elongated member having a proximal portion and a distal portion, the elongated member configured for insertion so the distal portion extends distal of a clot in the blood vessel. A sensor is positioned at the distal portion of the elongated member for positioning distal of the blood clot, the sensor measuring a parameter of blood downstream of the clot. An indicator communicates with the sensor, the indicator indicating a measured parameter for insertion of an instrument for controlling blood flow.
US10376670B2
A processing system includes methods to promote sleep. The system may include a monitor such as a non-contact motion sensor from which sleep information may be determined. User sleep information, such as sleep stages, hypnograms, sleep scores, mind recharge scores and body scores, may be recorded, evaluated and/or displayed for a user. The system may further monitor ambient and/or environmental conditions corresponding to sleep sessions. Sleep advice may be generated based on the sleep information, user queries and/or environmental conditions from one or more sleep sessions. Communicated sleep advice may include content to promote good sleep habits and/or detect risky sleep conditions. In some versions of the system, any one or more of a bedside unit 3000 sensor module, a smart processing device, such as a smart phone or smart device 3002, and network servers may be implemented to perform the methodologies of the system.
US10376667B2
An intranasal device having a first cannula for insertion into a first nostril of a user and a second cannula for insertion into a second nostril of a user. Each cannula has an interior surface defining a generally cylindrical lumen. On the exterior surface of each cannula is a first protrusion in the shape of an anteromedial concavity of a nostril of the user and second, separate and distinct protrusion in the shape of a posterolateral concavity of the nostril of the user.
US10376663B2
The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.
US10376662B2
The disclosure describes powder inhalers and dry powder inhaler storage cassettes that include a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance. The compartment is configured such that the preloaded doses are sealed within the compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system. The moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier. The sealing system is in sealing configuration prior to an advancement of the carrier, is relaxed upon an advancement of the carrier and is returned to its sealing configuration at the latest after release of the powder associated with the area of the carrier.
US10376652B2
The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle.
US10376645B2
The present disclosure concerns a drive mechanism for a drug delivery device, having a first and a second state and comprising a piston rod configured to be moved in a distal direction when the drive mechanism is operated and an adjusting member, wherein the adjusting member is rotatable relative to a body of the drug delivery device in the first state of the drive mechanism and is prevented from rotating relative to the body in the second state of the drive mechanism, and wherein the adjusting member is configured to adjust an axial position of the piston rod in the first state of the drive mechanism.
US10376644B2
A system comprising a sensor assembly adapted to measure a magnetic field, and a mechanical assembly comprising an indicator element with a magnet moving together therewith, the magnet being configured to generate a spatial magnetic field which relative to the sensor assembly varies corresponding to the spatial position and orientation of the magnet, wherein the indicator element is adapted to both rotate and move axially during operation of the assembly. Processor means is configured to determine on the basis of measured values both a rotational position and an axial position of the indicator element.
US10376637B2
The invention relates to an insertion device comprising —a penetrating member (50) connected to transformation means (52), —a moving part (38) comprising guiding means (39) which guiding means (39) restrict the movement of the transformation means (52) and guide the penetrating member (50) from a first to a second position in a first direction, i.e. the direction of insertion, towards the injection site, and —a stationary housing (30) comprising guiding means (32) which guiding means (32) restrict the movement of the moving part (38). The guiding means (32) guide the moving part (38) in a second direction which is linear and different from the first direction i.e. the direction of insertion.
US10376628B2
The present invention relates to a method for removing fluid from a blood filter which is used for the blood treatment of a patient and/or for removing blood from an extracorporeal blood circuit at the end of a blood treatment session. It further relates to a medical treatment apparatus with a control and/or regulating device which executes the method according to the present invention. It further relates to a digital storage medium, a computer program product as well as a computer program for executing the method according to the present invention.
US10376621B2
A signal processing circuit for controlling operation of an implanted ventricular assist device comprising an input module for receiving one or more signals of a patient from one or more sensors. A processor for processing the received signals is included, the processor configured to compare a total blood output on a left side of the patient's heart with a total blood output on a right side of the patient's heart; determine at least one from the group consisting of the presence of fluid imbalance between the left and right sides of the patient's heart and the absence of fluid imbalance between the left and right sides of the patient's heart based on the comparison; and when the presence of fluid imbalance is determined, control the implanted ventricular device to restore fluid balance between the left and right sides of the patient's heart.
US10376619B1
An improved percutaneous endoscopic gastrostomy (PEG) tube that allows continuous suctioning/sumping without occlusion of the tube by the gastric wall. The PEG tube includes a hollow drainage tubing coupled to a ventilated bell cap. The bell cap can be open or closed to the external environment is ventilated via apertures, crenellations and grooves, and hemispherical arches. The PEG tube minimizes, or completely eliminates, the need for a user thereof to frequently flush the tube, thus also curtailing intermittent suctioning and allowing for longer periods of uninterrupted drainage. Furthermore, the PEG tubes of the current invention reduce clogging of the tube by larger gastric matter that is intended to be suctioned out of the patient or subject.
US10376618B2
A thoracic catheter system comprises a flexible thoracic catheter for inserting into a thoracic cavity of a human. A distal end of the thoracic catheter has a plurality of apertures. A proximate end of the thoracic catheter is designed to extend out of the thoracic cavity. A three way valve is one of fused with and removably attached to the proximal end of the thoracic catheter.
US10376606B2
A sterilizing sheet is excellent in terms of saving space when a sterilizing operation is being performed, and sterilizing objects of various sizes. This sterilizing sheet is provided with a flexible sheet body, a sheet accommodating body and a handle. The sheet body is formed from a dielectric and a pair of electrodes accommodated inside the dielectric. The sheet accommodating body is a cylindrical body in which the sheet body is accommodated to be capable of being pulled out and rewound, and is provided with a case, a rotating body and a rewinding mechanism. The rewinding mechanism is a mechanism for automatically rewinding the sheet body, when pulled out from the sheet accommodating body, back into the sheet accommodating body. The handle is attached to a distal end portion of the sheet body, and includes, inside the handle, a battery, a switch mechanism, a booster circuit and a monitoring circuit.
US10376605B1
A sanitization system for an amusement park includes a compartment disposed in a ride vehicle of an amusement park ride, where the compartment is configured to receive an article of the amusement park ride, an ultraviolet light source disposed in the compartment, where the ultraviolet light source is configured to transmit ultraviolet light toward a surface of the article when the article is positioned in the compartment, and a nozzle disposed in the compartment, wherein the nozzle is configured to direct a sanitizing fluid toward the surface of the article when the article is positioned in the compartment.
US10376603B2
Provided are protein polymers providing the dual functionality of delivery and imaging. The protein polymers comprise a coiled-coil domain of the cartilage oligomeric matrix protein and repeats of elastic like peptides. The coiled-coil domain allows delivery of molecules, the elastin-like peptide domain provides thermo-responsive functionality, and a plurality of leucine residues, which can be fluorinated, provide imaging functionality.
US10376590B2
The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating to delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained release delivery system includes a flowable composition containing risperidone, a metabolite, or a prodrug thereof and an implant containing risperidone, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become a solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite or a prodrug thereof.
US10376587B2
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
US10376586B2
A method for solubilizing non-polar target compounds into a carrier liquid is described. A carrier oil, such as a MCT, or a mixture of MCTs, may be used to solubilize non-polar target compounds. The carrier oil may also include one or more buffers for stability of the target compounds within the carrier oil.
US10376582B2
The invention provides buffered formulations of adalimumab. The formulations comprise a buffer comprising an acetate salt, mannitol, glacial acetic acid, sodium chloride, and polysorbate 80. The formulations have an acidic pH, and enhance the thermal, conformational and colloidal stability of antibodies, including the adalimumab antibody.
US10376571B2
Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
US10376569B2
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10376567B2
This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines and chimeric molecules) that elicit an immune response specifically directed against cancer cells expressing a CAIX antigenic marker. The novel CAIX variant and related compositions are useful in a wide variety of treatment modalities including, but not limited to protein vaccination, DNA vaccination, and adoptive immunotherapy.
US10376555B2
Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.
US10376554B1
A powdered or liquid juice product for hangover treatment containing juiced ingredients of red onion, cucumber, and romaine lettuce. Other embodiments contain onion, cucumber, and one or more of any other leafy green vegetable. The components of the applicant's invention create a novel synergistic effect because the combination creates a greater effect than the sum of the effects of the components separately.
US10376548B2
Compositions and methods are provided for improving the health of an animal by reducing certain diseases and by binding certain heavy metals that may be unintentionally introduced into the body of the animal from the environment. Compositions and methods are also provided for improving the feed conversion ratio of an animal. In addition, compositions and methods are provided for reducing nitrate pollution in the environment. In one embodiment, the composition may include mastic gum, a mixture of ionic minerals, and optionally an essential amino acid not produced by the animal. The ionic minerals may be derived from water sourced from an inland sea such as the Great Salt Lake, the Dead Sea, or another inland sea. The essential amino acid may be included in the form of a protein. The animal may be a ruminant, poultry, or other animal. Methods are also provided for processing mastic gum.
US10376543B2
The invention relates to provide a fermented milk product includes angiogenin and/or angiogenin hydrolysate in an amount of 0.9 mg/100 g to 150 mg/100 g, and lactoperoxidase and/or lactoperoxidase hydrolysate in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.3 to 23.
US10376541B2
There are disclosed topical silver(II) antibiotic formulations. Other embodiments are also disclosed.
US10376535B2
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.
US10376530B2
The present invention relates to a pharmaceutical composition for preventing or treating Gleevec-resistant leukemia, containing, as an active ingredient, ginsenoside F1 or Rg3 which exhibits a preventive or therapeutic effect on Gleevec-resistant leukemia through enhancing cell killing activity of NK cells; a method for treating Gleevec-resistant leukemia comprising a step of administering the pharmaceutical composition; and a food composition for preventing or ameliorating Gleevec-resistant leukemia. Since the pharmaceutical composition of the present invention can effectively treat leukemia that exhibits resistance to conventional Gleevec, the pharmaceutical composition can be widely used for effective leukemia treatment.
US10376529B2
The present invention is related to a product comprising a pentacyclic triterpene of formula (I) and a hydroxytyrosol or derivatives thereof of formula (II), pharmaceutical compositions thereof and their uses as antioxidants, anti-inflammatories and neuron protectors.
US10376528B2
The present invention provides a composition comprising a mixture of an exogenous ketone body, an exogenous NAD modulator and a methyl donor. Typically, exogenous NAD modulator is an exogenous nicotinamide adenine dinucleotide (NAD) precursor. The present invention also provides a method of using such a composition for treating various clinical conditions, including metabolic disorders and neurocognitive impairments. The compositions of the invention can also be used to improve human performance in various competitive or environmental conditions.
US10376520B2
The present invention discloses compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, or a solvate or the salt of a solvate thereof, pharmaceutical compositions comprising the same, and methods of treatment using the same, for use in the prophylaxis and/or treatment of cardiovascular disorders and/or dyslipidemia, by administering the compound according to Formula (I).
US10376518B2
The present invention provides a method for inducing CD8+FOXP3+ regulatory T cells in a subject which comprises administering to the subject: (i) a first agent which inhibits p38 phosphorylation; and (ii) a second agent which stimulates T-cell receptor (TCR) signalling. The method may be used to treat and/or prevent an autoimmune and/or inflammatory disease in a subject. The invention also provides compositions and kits for use in such methods.
US10376517B2
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
US10376509B2
Methods for inhibiting the activity of Clostridium difficile in a subject comprise administering to the subject in need thereof a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and a clofazimine analog selected from B746 clofazimine analog or B826 clofazimine analog.
US10376504B2
The present invention is directed to azacyanoquinolinone compounds of the general structural formula: (wherein R5 and R6 are defined herein) which may be useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
US10376498B2
Method for treating a viral infection in a patient, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, comprising a moiety represented by figure (I), wherein R1 is a saturated or unsaturated bivalent hydrocarbon group. Viruses subject to treatment can include HIV and flaviviruses such as west nile, dengue, or hepatitis C virus. Compositions and methods of isolation and purification are also described including from the Red Sea sponge.
US10376492B2
A compound is described that is selected from among macrocyclic lactones for treating and/or preventing a complication from a human papillomavirus infection. The complication to be treated and/or prevented can be selected from among malignant melanomas, skin carcinomas, in situ or invasive carcinomas, epidermoid carcinomas, Bowen's disease, head and neck cancers, upper aerodigestive tract cancers, laryngeal cancers, esophageal cancers, stomach cancers, oral papillomas, pharyngeal papillomas, laryngeal papillomas, esophageal papillomas, lung cancers, intravulval neoplasias, intravaginal neoplasias, intracervical neoplasias, cervical dysplasias, cervical carcinomas, penile cancer, intrapenile neoplasias, and in situ or invasive anal carcinomas.
US10376491B2
Disclosed are a pharmaceutical composition for treating non-alcoholic fatty liver and a method for preparing same. The composition is prepared from the following hulk drugs by weight ratio: 8.75-60 parts of silibinin, 15-65 parts of phospholipid, 25-200 parts of Pu'er tea extract, and 5-50 parts of radix puerariae extract.
US10376481B2
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.
US10376471B2
Provided is a dual dosage form capsule, methods for producing and systems for making the same, which can provide dual release of the two dosages. The dual dosage form capsule has a first capsule member containing a first fill material and a second capsule member containing a second fill material. A band couples the first capsule member to the second capsule member and forms a third chamber defined by an inner surface of the band and each cap of the capsule members. An aperture allows fluid into the third chamber causing the band to at least partially dissolve so that the caps of the capsule members are exposed. The caps of the capsule members can dissolve at the same or different rates to control the timing of the release of the first and second fill materials and hence an active ingredient included within the fill material.
US10376470B2
Solid dosage formulations containing a combination of rosuvastatin and ezetimibe, as well as methods of making such solid dosage forms and method of treating patients with fixed combination solid dosage forms of rosuvastatin and ezetimibe are provided here.
US10376465B2
The present invention is directed toward respirable dry powders and particles for systemic delivery of pharmaceutically active agents or delivery to the respiratory tract. The dry powders contain one or more monovalent metal cations (such as Na+), are small and dispersible.
US10376461B2
Described herein is a polyether polyamide block copolymer as well compositions and products containing the polyether polyamide block copolymer. Methods of making and using the copolymer, the compositions, and products are also described herein.
US10376460B2
Provided by the present invention is a corrigent composed of a copolymer having a weight average molecular weight of 10,000-5,000,000 and comprising 10-90 mol % of a constitution unit based on 2-(meth)acryloyloxyethylphosphoryl choline, and90-10 mol % of a (meth)acrylic monomer containing an alkyl group, a (meth)acrylic monomer containing a quaternary ammonium group and a constitution unit based on a (meth)acrylamide monomer. The present invention also provides a composition for mouth cavity containing the corrigent.
US10376458B2
The invention includes methods for reducing or preventing the staining capacity of a compound to a tooth in a mammalian oral cavity, which includes affixing to the tooth surface a degradable film. The film comprises a starch polymer or copolymer that is formed by crosslinking a starch. The film degrades in the oral cavity within about 1 minute to about 70 minutes after affixation. In some embodiments, it may be preferred the crosslinking occurs in the presence of at least one (poly)carboxylic acid. It may be preferred that the starch selected is a retrograde starch, a starch that is chemically or physically modified to be amylase resistant or a starch that is derived naturally but exhibits amylase resistance.
US10376456B2
The invention relates to aqueous, high active, self-preserving composition of mild surfactants which are used to create transparent liquid formulations with pH similar to skin's pH. More specifically, the composition comprise of sodium/potassium acyl isethionate of Formula I and mono potassium acyl glutamate of Formula II with solids content of at least 45 w/w, for personal care formulation that are ultra-mild, with skin pH and transparent.
US10376455B2
The present disclosure provides biophotonic topical compositions and methods useful in phototherapy. In particular, the biophotonic topical compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.
US10376448B2
The invention relates to a method for applying a cosmetic composition to hair. The method comprises the steps of removing a cosmetic composition from a sealed container, the composition comprising: a post-foaming emulsion comprising a weak acid, a weak base, a fatty acid, and a volatile buffering agent; a film forming agent; and an aqueous carrier; applying said composition to one or more eyelashes; and during or after said application to said one or more eyelashes, said cosmetic composition forms a foam, said foam resulting from the release of a gas, said gas being a reaction product of said post-foaming emulsion, and said reaction commencing after the evaporation of said volatile buffering agent, upon exposure of said cosmetic composition to atmospheric conditions.
US10376447B2
An enteral feeding system including: an enteral feeding tube, a pump configured to draw a liquid from a reservoir to the enteral feeding tube; a switching mechanism associated with at least four vacuum lumens provided with the enteral feeding tube; and a controller configured to automatically control the pump and the switching mechanism wherein controlling the pump and the switching mechanism includes coordinating the operation of the switch with the operation of the pump.
US10376442B2
Systems and methods are provided for controlling infrared radiation (IR) sources of a sauna including tuning IR wavelength-ranges and radiated power-levels of IR sources, and directing IR to locations on a user's body. In one illustrative embodiment, a sauna may be provided having adjustable heat sources to emit IR at any wavelength resulting in a desirable radiation treatment for the sauna user. In another illustrative embodiment, a method is provided for tuning IR sources in a sauna.
US10376441B2
An example system includes a first wearable computing device, and at least one additional wearable computing device. The first wearable computing device is configured to retrieve information regarding a series of tasks to be performed in treating a patient in cardiopulmonary arrest. The information includes, for each task, an indication of a user to perform the task, an indication of a time point to perform the task. The first wearable computing device is further configured identify one or more subsets of the information, and transmit each subset to a different corresponding one of the additional wearable computing devices. Each additional wearable computing device is configured to receive, from the first wearable computing device, at least one of the one or more subsets of the information, and output, for each task within a received subset, a corresponding prompt to perform the task at the respective time point associated with the task.
US10376436B2
The present invention relates to a conveyor mechanism with illuminated chamber for concealment of coffin consisting of a base or travel platform on which a plurality of rollers are arranged, through which it is possible to manually move a coffin from an open or full vision area to a transition zone that conceals said coffin, where the transition zone is defined from a concealment chamber that covers the rear half of the base or travel platform and in which a tunnel is configured through which the coffin is circulated to reach its final destination, a journey that is carried out accompanied by the light provided by at least two reflector lamps arranged at the bottom of the concealment chamber.
US10376428B2
A disposable absorbent pant having a belt structure that encircles the wearer's waist, with front and rear belt portions, and a longitudinally channeled absorbent core structure, is disclosed. The channels are extended so as to underlie at least one of the front and rear belt portions, thereby providing added structural support to restrain the absorbent core and reduce the likelihood of undesirable bulging in the front and/or rear of the pant while it is worn, after the core has absorbed liquid and stiffened longitudinally as a result of the channeled structure.
US10376426B2
A low-bulk disposable absorbent pant for a child is disclosed. The pant may have a belt structure formed of a stretch laminate of a pre-strained elastic film between two nonwoven layers. The belt may have a relaxed lateral size and a stretched lateral size that is at least 150% of the relaxed lateral size, the relaxed lateral size being no more than 400 mm. The pant may include one or more of waistband, leg band and supplemental elastic members.
US10376419B2
Method of absorbing moisture around breasts of a person by inserting a bra liner made at least partly of absorbent material under a breast support between the skin of the chest and skin of each of right and left breasts, and partly between the right and left breasts. The bra liner includes a left portion, a right portion and a central portion between the left and right portions, the central portion including a flap partly separated from the left and right portions. The flap is folded about a center line of the body to thereby interpose the folded flap between the right and left breasts and maintain the right and left breasts out of contact with one another.
US10376417B2
An emergency head trauma bandage cap with a detachable strap system and method of use, which, when applied to the head, delivers minimal pressure to control bleeding, doesn't compromise cervical spine immobilization, allows for fast and effective application of cooling gel to control intracranial/internal swelling or hot packs to prevent hypothermia in non-trauma situations, doesn't come apart during treatment and transport, and doesn't require a caregiver to re-wrap the dressing.
US10376414B2
Systems, apparatuses, and methods include a surgical apparatus with a handle for grasping by a user and a multi-function surgical portion extending therefrom. The multi-function surgical portion may include an illuminator portion arranged to provide illumination to a surgical region of a patient during a surgical procedure, and tissue-treating portion coaxially aligned with the illuminator portion.
US10376411B2
In an adjuster for an airway securing device, a base member fixed to one of an upper jaw side attachment body and a lower jaw side attachment body is provided with a base member side half tube part and a slide member fixed to the other of the upper jaw side attachment body and the lower jaw side attachment body is provided with a slide member side half tube part. The base member side half tube part and the slide member side half tube part form a tube part in which an adjusting bolt is disposed on its inner peripheral side. A base member side flange part is formed at a base end of the base member side half tube part and a slide member side flange part shape is formed at a base end of the slide member side half tube part.
US10376406B2
A urine collection device has a chamber assembly, which includes a layer of wicking material and porous material. The porous material is configured to form a chamber in which urine can be collected for transport; and the wicking material is disposed about the porous material. The chamber has a port for receiving a tube so that urine collected within the chamber can be transported from the chamber by being drawn from the chamber when a partial vacuum is applied within the chamber via the received tube. The chamber assembly is so dimensioned and configured that opposing portions of the assembly are sufficiently adjacent as to define an opening through which the head of a penis can be inserted. A layer of impermeable material is so attached to the chamber assembly as to cover one side of the opening and thereby provide a receptacle for receiving the head of an inserted penis.
US10376398B2
A delivery device and methods for deploying an endovascular prosthesis within the common and internal iliac arteries are described. The device comprises a pusher catheter having a proximal end and a pusher extension extending proximally therefrom. A tubular prosthesis having a side branch is releasably coupled to the pusher extension. An extension dilator extends proximally from the proximal end of the pusher catheter, extends at least partially along an external surface of the main tubular body, into a distal end of the side branch and exits a proximal end of the tubular prosthesis. The extension dilator can be tracked over a guide wire which serves to both position the device within a vessel and also to facilitate cannulation of an internal iliac artery.
US10376384B2
A device for use in placing a prosthesis in a patient during joint replacement surgery is disclosed. The device may comprise a body formed using medical imaging data corresponding to an anatomic structure of the patient and a final installation position of the prosthesis. The body may extend between a lower surface and an upper surface and may have an aperture extending therethrough. The body may also have an anatomic alignment member extending outward from an outer surface of the body and include an inner surface opposite the outer surface. The inner surface may define at least part of the aperture. The prosthesis alignment member may extend from the inner surface and the prosthesis alignment member may include a prosthesis alignment surface configured to align with a prosthesis in the final installation position.
US10376383B2
Bi-directional fixating/locking transvertebral body screw/intervertebral cage stand-alone constructs
A bi-directional fixating transvertebral (BDFT) screw/cage apparatus is provided. The BDFT apparatus includes an intervertebral cage including a plurality of internal angled screw guides, a plurality of screw members, and a novel screw locking mechanism which consists of leaf springs which mechanically interact with BDFT screws which have ratcheted screw heads. The small leaf springs allow the ratchet teeth of the screw heads to rotate only in the penetrating direction. Due to the geometric orientation of the ratchet teeth vis-a-vis the adjacent spring leaf, rotation of the screw head in the opposite direction is prevented by the insertion of the string leaf in the space between the ratchet teeth (trough) of its final rotation. The uni-rotational interaction between the screw head-ratchet teeth/troughs and adjacent leaf spring is the mechanical basis for this novel locking mechanism. The internal angled screw guides orient a first screw member superiorly and a second screw member inferiorly in some embodiments, and orient a second screw member and a third screw member superiorly, and a first screw member and fourth screw member inferiorly in other embodiments. The intervertebral cage is adapted for posterior lumbar intervertebral placement, anterior lumbar intervertebral placement, anterio-lateral thoracic intervertebral placement, or anterior cervical intervertebral placement.
US10376376B2
An artificial replacement disc includes a pair of substantially parallel plates formed to occupy a space defined by vertebral endplates, each of the plates including a plurality of spikes on a first surface and a concave trough formed on a second surface opposite of the first surface. A mobile core includes a core rim with opposing convex surfaces extending from opposite sides of the core rim, the mobile core being capable of being disposed between the pair of plates to permit the vertebral endplates to move relative to one another. The spikes on each of the plates extend substantially away from the mobile core and the convex surfaces are formed to integrally fit within the concave trough of at least one of the plates. The core rim limits lateral movement of the mobile core relative to the parallel plates. One or more insertion tools for inserting and implanting the replacement disc are also described.
US10376374B2
An intervertebral implant has a hollow space formed within the implant and accessible through an elongate opening extending through a recessed portion of the side wall, and the hollow space is shaped to receive an engagement portion of a drive shaft of an insertion tool; and the intervertebral implant includes at least two guiding surfaces facing each other and being configured for sliding engagement by a portion of a sleeve of the insertion tool movably holding the drive shaft.
US10376373B2
Embodiments herein are generally directed to vertebral implants and implant trials for use with vertebral implant assemblies. In some embodiments, these implants and implant trials may be used in conjunction with corpectomy procedures.
US10376372B2
An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.
US10376359B2
Embodiments of the present disclosure are directed to stents, valved-stents, and associated methods and systems for their delivery via minimally-invasive surgery.
US10376358B2
A device for joining individual leaflets for repairing a cardiac valve of a patient has a base and projection fingers rising from the base to support adjacent leaflets for tacking together by sewing overlapping edges of adjacent leaflets prior to emplacement into the patient. The invention provides a cutting tool for excising leaflets from a pericardial tissue sheet according to predetermined sizes and shapes. A leaflet having a desired contour and size is obtained by pressing the tool formed as a cutter block against the tissue sheet. A set of blocks can be provided wherein each cutter block has an outer edge following a respective contour and size for a leaflet, and wherein the outer edge includes a raised cutting edge for pressing through the pericardial tissue sheet. The blocks can be held in a press for assisting in pushing the cutting edge through the tissue.
US10376355B2
The embodiments herein relate to an artificial diaphragm made up of a plurality of plates having nanoparticles which move to-and-fro creating a movement similar to a natural diaphragm. The embodiments herein provide an artificial diaphragm that can mimic diaphragmatic movements of a natural diaphragm in a human body. The artificial diaphragm is embedded with intelligent nanomagnetic particles which is used for treatment of diaphragmatic paralysis.
US10376354B2
A joining arrangement between a main tube (3) and a side arm (5) in a side arm stent graft (1). The side arm (5) is stitched into an aperture (11) in the main tube and is in fluid communication with it. The aperture is triangular, elliptical or rectangular and the side arm is cut off at an angle to leave an end portion having a circumferential length equal to the circumference of the aperture. The side arm can also include a connection socket (76) comprising a first resilient ring (79) around the arm at its end, a second resilient ring (80) spaced apart along the arm from the first ring and a zig zag resilient stent (82) between the first and second rings. The zig-zag resilient stent can be a compression stent. Both the main tube and the side arm are formed from seamless tubular biocompatible graft material.
US10376347B2
An attachment mountable to an electric toothbrush handle having a drive shaft comprises a neck member having an elongated body with a principal axis and a cavity; a slide member with an engagement surface; a guide sleeve member having a cavity, a first outer surface with an engagement opening, and a transition surface; and a collar member. The guide sleeve member, with slide member inserted within the engagement opening, is inserted within the neck member cavity. Insertion of the drive shaft into the collar member and guide sleeve member from a first radial position along an axis offset and parallel to the principal axis to a second radial position in-line with the principal axis, via the transition surface, results in the drive shaft being held in frictional contact with the engagement surface of the slide member to enable transfer of force/motion from the drive shaft to the neck member.
US10376346B2
A dental cleaning tool includes a body portion defining a longitudinal axis of the dental cleaning tool. The body portion includes a floss assembly including a first arm and a second arm extending substantially perpendicularly relative to the longitudinal axis, a receiving slot formed in the first arm, and a shield formed on the first arm. The shield is configured to cover the receiving slot such that access to the receiving slot is restricted from a first direction. The tool also includes a secondary cleaning tool coupled to the first arm. The secondary cleaning tool is pivotable relative to the first arm in at least two degrees of freedom such that the secondary cleaning tool is insertable into the receiving slot from a second direction different than the first direction.
US10376342B2
A fixation pin for fixing a dental drill template. The fixation pin has a head having a bearing surface that is intended to bear at least partially on the drill template, or a sleeve provided in the drill template. The fixation pin has a rod having a shape of an essentially circular cylinder and extending from the bearing surface at an essentially right angle. The rod is intended to be inserted into the drill template or the sleeve provided in the drill template.
US10376341B2
The present disclosure provides an assembly and system allowing for secure use of an orthodontic auxiliary, particularly a bite corrector, with lingually bonded appliance systems. In one aspect, the disclosure features an orthodontic assembly including a banded tube, a force module, a connector coupling the force module to the tube, and an attachment device secured to the labial surface of an anterior tooth and connected to mesial, outer end of the force module.
US10376335B2
In a method and an apparatus to provide updated images during a robotically-implemented surgical procedure, 3D data is obtained of a volume of a patient, which includes anatomy involved in the procedure. The anatomy is segmented from a reconstructed image of the volume. During the procedure, the surgeon applies forces on the anatomy, causing a geometric change of the anatomy. Force sensors in the surgical robot detect these forces, which are supplied to a processor that controls display of the segmented anatomy at a display screen. From the applied forces and the physical properties of the anatomy, the processor calculates the geometric change of the anatomy that has occurred and modifies the appearance and/or position of the displayed segmented anatomy on the display screen in real time during the procedure, so as to visualize the geometric change.
US10376329B2
A medical device tray for carrying a plurality of medical devices includes: a base made of a substantially rigid material, the base forming at least one base through-hole; and a covering affixed to the base, the covering being made of a material which is softer than the substantially rigid material of the base, the covering forming at least one covering through-hole, the at least one base through-hole and the at least one covering through-hole cooperating to form at least one medical device tray through-hole configured for directly supporting a respective one of the plurality of medical devices.
US10376326B2
A multi-layer, super-planar laminate structure can be formed from distinctly patterned layers. The layers in the structure can include at least one rigid layer and at least one flexible layer; the rigid layer includes a plurality of rigid segments, and the flexible layer can extend between the rigid segments to serve as a joint. The layers are then stacked and bonded at selected locations to form a laminate structure with inter-layer bonds, and the laminate structure is flexed at the flexible layer between rigid segments to produce an expanded three-dimensional structure, wherein the layers are joined at the selected bonding locations and separated at other locations. A layer with electrical wiring can be included in the structure for delivering electric current to devices on or in the laminate structure.
US10376325B2
Methods, systems, and apparatuses for controlling surgical systems. In one aspect, a method includes obtaining, at a control subsystem associated with a surgical system, hardware configuration information from a first patient side subsystem that is communicatively coupled to and controlled by the control subsystem; determining a software version to be used by the control subsystem and the first patient side subsystem, wherein determining the software version includes selecting the software version from among a plurality of software versions, and wherein each software version of the plurality of software versions is associated with a particular patient side subsystem; instructing the first patient side subsystem to use the software version; determining whether the software version is currently loaded on the control subsystem; in response to determining that the software version is not currently loaded on the control subsystem, loading the software version on the control subsystem; and initializing the surgical system.
US10376324B2
A system and method for an articulated arm stabilization includes an arm stabilizer for use with articulated arms of a computer-assisted medical device. The stabilizer includes a spine, a first vibration absorbing mount attached to the spine, a second vibration absorbing mount attached to the spine, a first clamp attached to the first vibration absorbing mount, and a second clamp attached to the second vibration absorbing mount. The first clamp is adapted to hold a first attachment point of a first articulated arm without slipping. The second clamp is adapted to hold a second attachment point of a second articulated arm without slipping. In some embodiments, the arm stabilizer stabilizes and reduces vibration in the first and second articulated arms. In some embodiments, the vibration is in a range from 0.5 to 14 Hz. In some embodiments, the spine limits relative motion between the first clamp and the second clamp.
US10376317B2
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
US10376311B2
Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.
US10376309B2
A cable assembly includes a rigid portion, a flexible central portion, and a radiating portion. The rigid portion is configured to couple to a source of electrosurgical energy and to prevent fluid ingress towards the source of electrosurgical energy. The flexible central portion extends from the rigid portion and includes an inner conductor, a dielectric disposed about the inner conductor, and a conductive braid disposed about the dielectric. The radiating portion extends from the central portion and is configured to deliver electrosurgical energy to tissue.
US10376308B2
A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.
US10376307B2
This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.
US10376302B2
A bipolar electrosurgical device is disclosed that operates in a mechanical cutting mode and a hemostasis mode. The device includes a housing and a blade assembly extending from the housing. The blade assembly forms a cutting tip and cutting window at a distal end region to provide mechanical cutting of tissue and first and second electrode assemblies to provide electrical energy to tissue. The first and second electrode assemblies can each include a rotary connection assembly to allow spatial orientation of the cutting window relative to the housing and/or cutting tip.
US10376301B2
An electrosurgical generator includes an RF output stage, a current sensor, a voltage sensor, first and second log amplifiers, and a controller. The RF output stage is configured to supply electrosurgical energy to tissue. The current sensor is configured to sense a current of the electrosurgical energy and generate a current signal corresponding to the current of the electrosurgical energy. The first log amplifier is configured to amplify and compress the current signal. The voltage sensor is configured to sense a voltage of the electrosurgical energy and generate a voltage signal in response thereto. The second log amplifier is configured to amplify and compress the voltage signal. The controller is configured to receive the amplified voltage signal and the amplified current signal and operatively control the generation of the electrosurgical energy as a function of the amplified voltage signal and the amplified current signal.
US10376300B2
Methods and devices for treating nasal airways are provided. Such devices and methods may improve airflow through an internal and/or external nasal valve, and comprise the use of mechanical re-shaping, energy application and other treatments to modify the shape, structure, and/or air flow characteristics of an internal nasal valve, an external nasal valve or other nasal airways.
US10376297B2
A bone fixation clamp includes a first arcuate clamp member conforming to a shape of a bone and extending between a first connection end and a first free end, a second arcuate clamp member conforming to a shape of the bone, a second connection end of the second clamp member being pivotally attached to the first clamp member, the second clamp member extending between the second connection end and a second free end and a driving member received in the first clamp member passing out of the first clamp member to abut an abutment portion of the second member so that, as the driving member is extended further out of the first member, the driving member pivots the second clamp member relative to the first clamp member to draw the first and second free ends toward one another to apply a radially compressive force to the bone.
US10376279B2
A disposable scalpel, including a body portion having a proximal end and a distal end, a scalpel blade receiving slot formed in the distal end, and first and second parallel elongated flexible members, wherein the slot is positioned between the pair of parallel elongated flexible members, such that a scalpel blade received in and extending from the slot would be flanked by the pair of parallel elongated members.
US10376275B2
Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.
US10376274B2
According to an aspect of some embodiments of the present invention there is provided a device for removal of obstructive material from a vessel comprising: an expandable structure sized for insertion into the vessel; and one or more portion protruding radially from a central longitudinal axis of the expandable structure such that a space between the protrusion and a closest portion of the expandable structure to the portion includes a radial component; wherein the space is sized and shaped to be suitable to accept obstructive material.
US10376270B2
An orthopedic device includes a patient-specific acetabular guide that may be used for preparing an acetabulum of a patient to receive an acetabular implant. The acetabular guide has a body with an outer three-dimensional surface configured to match an acetabulum of a specific patient's hip joint designed from data of the patient's hip joint. The acetabular guide may further include a peripheral annular rim.
US10376268B2
Methods and devices for performing an osteotomy produce a bone cut producing a multi-planar change in the alignment of a bone portion by rotating it relative to another bone portion.
US10376265B2
Devices are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the intestinal tract and a distal location within the intestinal tract. An anastomosis compression assembly includes a first portion and a second portion, each including two or more segments securely fixed together by a pair of degradable joining members, and each further including interlocking mechanisms. The first portion and second portion are configured to be coupled together from different locations within the intestinal tract by the application of force. Once aligned, the first and second portions are securely attached to one another by engaging their respective interlocking mechanisms. After completion of the anastomosis procedure, the degradable links degrade and separate the anastomosis compression assembly into smaller fragments for ease of passage through the patient's intestinal tract.
US10376263B2
A surgical system includes an anvil that has, one, an elongate slot extending longitudinally along a length of the anvil and, two, a plurality of first staple-forming pockets. The surgical system further includes an anvil modification member releasably attachable to the anvil, wherein the anvil modification member comprises a plurality of second staple-forming pockets. In addition, the surgical system also includes a staple cartridge that has a plurality of staples formable by the plurality of first staple-forming pockets when the anvil modification member is not attached to the anvil, and wherein the staples are formable by the plurality of second staple-forming pockets when the anvil modification member is attached to the anvil.
US10376260B2
An apparatus includes first and second fixation members, a flexible member coupled to the first and second fixation members, and a limiting element coupled to the flexible member. The limiting element is movable relative to the second fixation member and acts to limit loosening of the flexible member relative to the second fixation member. The limiting element can be slidably received by the flexible member. The flexible member can be coupled to the fixation members such that pulling on a free end of the flexible member shortens a length of the flexible member between the fixation members.
US10376252B2
The present invention provides a method of repairing a defect in an abdominal wall of a subject, including the steps of: making a small incision through a skin layer above the defect in the abdominal wall, introducing a surgical device including a deformable body through the incision to reach a preperitoneum underlying the abdominal wall around the defect, using the surgical device to identify a protruded region of the preperitoneum extending towards the abdominal wall around the defect, and flattening the protruded region of the preperitoneum and separating the protruded region of the preperitoneum from the abdominal wall with the deformable body in an expanded condition. The method results in low recurrence of abdominal wall defect, less pain, and a shorter hospital stay after surgery.
US10376250B2
A medical navigation system is provided for performing at least part of an assessment of a non-living body. The medical navigation system comprises a positioning device having a positioning arm with an end effector at the end of the positioning arm, an imaging device coupled to the end effector, and a controller electrically coupled to the positioning device and the imaging device. The controller has a processor coupled to a memory and a display. The controller is configured to generate a signal to move the positioning arm to position the imaging device through a range of motion to perform a scan of a surface of the body and receive and save as data in the memory signals generated by the imaging device during the range of motion.
US10376248B2
A dart for use in gathering a tissue sample from an animal is disclosed. The dart has an adapter base for fastening to an elongated dart delivery shaft. The adapter base has a distal threaded end. A dart tip is threaded onto the adapter base. The dart tip has a sharpened tubular end portion for entering through skin of an animal and a cylindrical chamber portion for receiving and holding at least part of a tissue sample. The chamber portion has a proximal portion adapted to be removably fastened to the distal threaded end of the adapter base and a distal portion merging with the sharpened tubular end portion, wherein the dart tip is configured to hold and retain the tissue sample received within the chamber portion while the dart tip is withdrawn from the animal.
US10376239B2
Provided are an ultrasound imaging apparatus and a method of processing an ultrasound image. The ultrasound imaging apparatus includes a display configured to display a moving image consisting of a plurality of ultrasound images that are played back according to a time order together with at least one icon, corresponding to at least one piece of change information for changing a display of at least one of the plurality of ultrasound images, in association with the time order.
US10376238B2
A method for customizing a probe grip of an ultrasound probe for a user is presented. The method includes printing the probe grip in a three-dimensional shape of the probe grip based on grip data corresponding to the user. Further, the method includes installing the printed probe grip on the ultrasound probe.
US10376236B2
An ultrasound diagnostic apparatus according to an embodiment includes processing circuitry. The processing circuitry sets a ROI in ultrasound image data that corresponds to at least one temporal phase and is among moving image data of two-/three-dimensional ultrasound image data acquired while using a region containing a tissue in motion as an image taking target. The processing circuitry obtains first position information of an estimated ROI based on movement information and second position information of an estimated ROI based on information other than the movement information, in ultrasound image data corresponding to the other remaining temporal phases within an acquisition period of the moving image data. The processing circuitry tracks the ROI, by obtaining position information combining the first and second position information based on an index related to reliability of the movement information, as position information of the ROI.
US10376233B2
In viscoelastic imaging with ultrasound, the shear wave speed or other viscoelastic parameter is measured by tracking at the ARFI focal or other high-intensity location relative to the ARFI transmission. Rather than tracking the shear wave, the tissue response to ARFI is measured. A profile of displacements over time or a spectrum thereof is measured at the location. By finding a scale of the profile resulting in sufficient correlation with a calibration profile, the shear wave speed or other viscoelastic parameter may be estimated.
US10376230B2
Breast density measurements are used to perform Breast Imaging Reporting and Data System (BI-RADS) classification during breast cancer screenings. The accuracy of breast density measurements can be improved by quantitatively processing digital mammographic images. For example, breast segmentation may be performed on a mammographic image to isolate the breast tissue from the background and pectoralis tissue, while a breast thickness adjustment may be performed to compensate for decreased tissue thickness near the skin line of the breast. In some instances, BI-RADS density categorization may consider the degree to which dense tissue is dispersed throughout the breast. A breast density dispersion parameter can also be obtained using quantitative techniques, thereby providing objective BI-RADS classifications that are less susceptible to human error.
US10376229B2
A computed tomographic mammography system is provided with, as an X-ray tube 1A, a transmission type X-ray tube including a target 2 which includes a target layer 2a that generates X-ray upon irradiation of an electron beam and a supporting substrate 2b through which the X-ray generated upon irradiation of the electron beam to the target layer 2a passes, an electron emission source 3 for emitting an electron beam toward the target layer 2a.
US10376220B1
The present invention, herein is a method and apparatus that significantly limits the effect of high frequency (“HF”) interferences on acquired electro-physiological signals, such as the EEG and EMG. Preferably, this method comprises of two separate electronic circuitries and steps or electronics for processing the signals. One circuit is used to block the transmission of HF interferences to the instrumentation amplifiers. It is comprised of a front-end active filter, a low frequency electromagnetic interference (“EMI”) shield, and an isolation barrier interface which isolates the patient from earth ground. The second circuit is used to measure the difference in potential between the two isolated sides of the isolation barrier. This so-called “cross-barrier” voltage is directly representative of the interference level that the instrumentation amplifier is subjected to. This circuit is used to confirm that the acquired signals are not corrupted by the interference.
US10376209B2
A method of locating a nerve within an intracorporeal space includes advancing a distal end portion of a stimulator toward an anatomical target within the intracorporeal space, and periodically applying a first electrical stimulus from a first electrode disposed on a central axis of the stimulator. If a muscular response to the first electrical stimulus is detected, a locating electrical stimulus is then applied from a plurality of locations offset from the central axis of the stimulator, and a magnitude of the response of the muscle is monitored. A distance between the nerve and each of the plurality of locations is determined from the magnitude of the muscular response, and from a magnitude of the locating electrical stimulus provided at each of the plurality of locations. The location of the nerve is then triangulated from the determined distance at each of the plurality of locations.
US10376208B2
A nerve mapping system includes a plurality of electrodes, a sensor, and a processor in communication with each of the plurality of electrodes and the sensor. Each electrode is disposed on the distal end portion of one or more elongate medical devices configured to extend within an intracorporeal treatment area of a subject. The sensor is in communication with a muscle of a subject, and is configured to provide an output signal corresponding to a monitored response of the muscle. The processor receives an indication of the location of each electrode and an indication of a magnitude of the monitored muscular response. Using these parameters, the processor determines a distance to the nerve from the location of each of the plurality of electrodes, and constructs a virtual model of the nerve using the determined distance to the nerve at each of the plurality of locations.
US10376207B2
The invention relates to an apparatus (100) and a method for generating a model output x(ti) describing a circadian rhythm of a person (P) at a time ti. In a preferred embodiment, a light sensor providing the photic exposure (L(ti)) and an activity signal (A(ti)) indicating the current level of activity of the person (P) at the time ti based on motion measurements (via an accelerometer) are used to calculate a wakefulness variable (σ) that indicates if the person (P) is awake or sleeping. The wakefulness variable is then used to determine a driving term (N(t)) for a driven oscillator model (135) which simulates the model output x(t) under the joint influence of light and activity.
US10376196B2
Embodiments of the invention relate to correlation of physiological data from two or more sources in real-time. As data is gathered from one or more remote physiological sensors, evaluation of associated physiological data takes place in real-time. The sensor data is correlated with other forms of data including objective physiological data, subjective physiological data, cognitive data, and/or quantitative input for multi-variate data analytics to assess and correlate the data. Alerts are generated, applications are activated, and windows are created to support the correlation and associated communication.
US10376194B2
A device for the extraction of blood or a blood compound is provided that includes a tube, a piston assembly, a handle assembly that can be clipped to the piston assembly, and a perforable sealing element that prevents the flow of fluid from a sealed interior space of the tube towards a longitudinal interior cavity of the handle assembly located adjacent to a separable area of the handle assembly. In use, the handle assembly is pushed to the bottom of the tube, causing the handle assembly to be clipped to the piston assembly, the handle assembly and the piston assembly are then moved rearwards forming a vacuum in the space, the piston assembly is clipped to an end cap of the tube and the gripping portion of the handle assembly is separated, obtaining a vacuum container with a perforable closure.
US10376191B1
The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
US10376185B2
A method implemented in a system which comprises a lightweight personal wearable monitoring device, supplied by a battery, comprising an accelerometer, a processing unit, a display, a remote server, said method comprising the steps: /a/ collecting, from a plurality of individuals caused to practice various physical activities from a set of predefined activities, acceleration data from sensing devices placed on each of said individuals, /b/ defining N small data-size specific metrics, computed from acceleration signals, which allow to define a global activity classifier, /c/ acquiring, at a first monitoring device worn by a first user, acceleration signals from the accelerometer of the first monitoring device, /d/ calculating, at the first monitoring device, over each lapsed time unit T1, specific metrics values from the sensed signals, to form a series of specific metrics values, /e/ send them to the processing unit, /f/ allocate an activity type for each time unit together with corresponding specific metrics values of the received series, to form a time chart of activity types presumably performed by the first user over a second period T2, /g/ display the time chart of activity types presumably performed by the first user on the display and allow the first user to confirm or correct partly the type of activity performed over the second period, and allow correction by the first user.
US10376184B2
A medical device includes a housing and an electrode arrangement coupled to the housing and configured to sense an electrical physiologic signal from a patient. The device also includes detection circuitry coupled to the electrode arrangement and configured to obtain a cardiac signal component and a non-cardiac signal component from the physiological signal. A processor is coupled to the detection circuitry. The processor is configured to detect patient activity using at least the non-cardiac signal component and discriminate between voluntary and involuntary activity of the patient based on a comparison of temporally aligned cardiac and non-cardiac signal components.
US10376178B2
A method comprises identifying linked anatomical structures in stored images of a patient anatomy and modeling a structure of linkage elements. Each linkage element corresponds to one of the linked anatomical structures. The method also includes modeling a portion of the patient anatomy as a plurality of search slabs and assigning each of the linkage elements to one of the plurality of search slabs. The method also includes receiving tracking data corresponding to a sensed instrument portion. The tracking data includes position information and orientation information for the sensed instrument portion. The method also includes identifying one of the plurality of search slabs which includes the position information for the sensed instrument portion and matching the sensed instrument portion to a matched linkage element from among the linkage elements assigned to the identified one of the plurality of search slabs.
US10376174B2
In order to provide an electrode equipped with an insulating wall having excellent patterning properties as well as excellent biocompatibility, there is provided an electrode including, on a substrate, an electrode element; and an insulating wall formed around the electrode element, constituted of a polysiloxane compound (component A) having, per molecule, two or more functional groups selected from the group consisting of a (meth)acryloyl group, a styrenic vinyl group, a vinyl ester group, a maleic acid ester group and a maleimide group, and formed from a polymer obtained by reaction of the functional groups.
US10376167B2
A system for recording, processing, and monitoring biosignals is provided, the system being configured to suspend data acquisition whenever an electric surgical tool or other generator of high frequency interference is in use. Such a system may protect the hardware of the system and reduce or eliminate the acquisition of distorted signals. The system of some embodiments includes an amplifier system configured to detect the presence of high frequency interference. Related methods are also disclosed.
US10376165B2
Systems and methods are described for the compositing together of model-linked vascular data from a plurality of sources, including at least one 2-D angiography image, for display in a frame of reference of the at least one angiography image. In some embodiments, a linking model comprises a data structure configured to link locations of angiographic images to corresponding elements of non-image vascular parameter data. The linking data structure is traversed to obtain a mapping to the frame of reference of one or more of the angiographic images.
US10376163B1
A system for detecting blood pressure based on imaging photoplethysmography (iPPG) includes a first inward-facing head-mounted camera to capture images of a first region of interest located on the face below the eyes and above the lips (IMROI1) of a user, and a second inward-facing head-mounted camera to capture images of a second region of interest comprising a portion of a temple and/or forehead (IMROI2) of the user. The system further includes a computer to calculate a blood pressure value for the user based on first and second photoplethysmographic signals recognizable in IMROI1 and IMROI2.
US10376161B2
[Problem] To provide a finger arterial dilatability testing method, finger arterial dilatability testing device, and finger arterial dilatability testing program with which it is possible to simply test for early signs of arteriosclerosis using the small vessels of the finger arteries.[Solution] In the present invention, the following are provided: a pulse wave data storage step for storing the resting pulse wave data and the reperfusion pulse wave data after releasing occlusion at one forearm, for the arteries of each finger of both hands which are clamped using a predetermined sequence; an NPV calculation step for calculating, on the basis of the pulse wave data stored in the pulse wave data storage step, an NPV for each heartbeat, where the NPV is obtained by dividing the amplitude of the alternating current component of the pulse wave by the average direct current component value of each pulse wave; a pulse pressure data acquisition step for acquiring the pulse pressure which is obtained by subtracting the diastolic blood pressure from the systolic blood pressure; and an FCR ratio calculation step for calculating, on the basis of the pulse pressure acquired by the pulse pressure data acquisition step, for each heartbeat the index (FCR ratio) that shows the vasodilation reaction of the finger arteries.
US10376158B2
Systems and methods are disclosed for moving a tabletop of a workstation based on biometric input associated with a user, the method being performed by a controller that is configured to send control signals to actuators to move the tabletop. One method includes: accessing a user profile associated with a user device; determining parameters for moving the tabletop, based on the user profile, for eliciting desired biometric inputs from the workstation user at one or more times during the movement of the tabletop; and repeating one or more iterations of: moving the tabletop based on the parameters, by sending control signals to the actuators of the tabletop; receiving, into a data storage device, actual biometric inputs from the workstation user; comparing the received actual biometric inputs with the desired biometric inputs; and if the parameters do not elicit the desired biometric inputs, adjusting the parameters.
US10376152B2
A measuring device (10) has at least one sensor (16, 18), which can be applied to the skin surface (12) of a patient for detecting a measured value with the sensor (16, 18). The device (10) has two contact surfaces (20, 22) on an underside (24), which is intended for being in contact with the skin surface (12) of the patient. A current detecting (32, 34), detects a measuring current (30) resulting from a particular effective electric resistance between the contact surfaces (20, 22). A method for operating such a measuring device (10) and a system with such a measuring device (10) are also provided.
US10376150B2
An imaging interface for diffuse optical tomography of breast includes a plurality of concentric rings. Each concentric ring can include a plurality of optical input/output apertures arranged on a radially inner surface thereof. The rings can have different inner and outer diameters from each other and can be arranged in a stacked configuration. The rings can translate independently of each other along a central axis of the stack. During imaging the breast is inserted into an inner region of the stacked rings. The rings can be translated such that the optical input/output apertures are brought into touch contact (i.e., non-compressing contact) with the surface of the breast, so as to accommodate different size breasts. The rings may be translated such that the spacing between adjacent rings is increased for large breasts and reduced for smaller breasts. Rings may be removed or additional rings added to further accommodate additional breast sizes.
US10376148B2
A fluorescence imaging device detects fluorescence in parts of the visible and invisible spectrum, and projects the fluorescence image directly on the human body, as well as on a monitor, with improved sensitivity, video frame rate and depth of focus, and enhanced capabilities of detecting distribution and properties of multiple fluorophores. Direct projection of three-dimensional visible representations of florescence on three-dimensional body areas advantageously permits view of it during surgical procedures, including during cancer removal, reconstructive surgery and wound care, etc. A NIR laser and a human visible laser (HVL) are aligned coaxially and scanned over the operating field of view. When the NIR laser passes over the area where the florescent dye is present, it energizes the dye which emits at a shifted NIR frequency detected by a photo diode. The HVL is turned on when emission is detected, providing visual indication of those positions.
US10376144B2
The present disclosure relates to techniques for receiving glucose data from a continuous glucose sensor and controlling the use and redistribution of that data so it is used in an intended manner. In one aspect, a system includes a plurality of continuous glucose monitor (CGM) devices; a plurality of display devices to receive data from the CGM devices classified into a plurality of classifications based on data type; a cloud server architecture to receive the data from the display devices on an intermittent basis, in which the data routed to a particular server of the plurality of servers is determined by the data type, and in which the intermittent basis varies depending upon data type; a plurality of remote monitor display devices; and an analysis and report engine.
US10376140B2
A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
US10376139B2
Methods for improving gaze tracking are presented. These methods eliminate the need for a separate initial calibration step to determine whether the subject is properly centrally fixated during testing. In one embodiment, whether the subject is centrally fixated is determined by identifying inlier and outlier gaze descriptors; the inliers are assumed to be associated with central fixation. This reduces the total time required for testing. These methods also improve the accuracy of gaze tracking during testing without the need for individual subject calibration. Instead, a database of reference eyes is used. The subject's eye can be compared to the reference eyes, and the mapping function for one or more reference matches can be used to estimate the subject's gaze direction. In another embodiment, previous calibration data from the same subject can be used to determine whether the subject is properly centrally fixated and/or the direction of the subject's gaze.
US10376136B2
There is provided a camera head for endoscope which enables to achieve a favorable fluorescent image in any wavelength band when the observation is switched over from a normal white-light image observation to an observation of fluorescent images of different wavelength bands.The camera head for endoscope includes a camera-head optical system which includes a spectral prism having a dichroic film which splits light from the endoscope into white light and fluorescent light, and a first image pickup element and a second image pickup element which are disposed in respective optical paths split into two by the spectral prism, and the first image pickup element is for the white-light image observation in which a white-light image is captured, and the second image pickup element is for a fluorescent-image observation in which two fluorescent images of different wavelengths are captured, and the first image pickup element is disposed at a position at which an image is formed in an optical path for the white-light image observation, and the second image pickup element is disposed at a position between two positions at which the two fluorescent images are formed in an optical path for the fluorescent-mage observation, and the camera head for endoscope satisfies the following conditional expression (1). d≤9×P×Fno (1)
US10376135B2
An object of the present invention is to provide an endoscopic surgery device and an outer tube, capable of easily obtaining an image desired by an operator to facilitate treatment as well as of performing minimally invasive surgery. In the endoscopic surgery device and the outer tube, an endoscope and a treatment tool are inserted into a body cavity through an outer tube. The outer tube is provided with a built-in slider. The slider is provided so as to be axially movable in the outer tube body. The endoscope and the treatment tool, inserted into the outer tube, are held by the slider. Moving the treatment tool allows endoscope to be moved in conjunction with the movement of the treatment tool.
US10376132B2
An adhesive roller assembly is provided having a non-cylindrical roller. The non-cylindrical roller is rotatably affixed to a handle's distal end. In addition, adhesive tape is helically wrapped about the roller, and the adhesive tape includes perforations so as to facilitate the breaking of the adhesive tape into individual segments. Because the roller has a non-cylindrical circumferential surface, the adhesive tape is deformed to have a non-cylindrical exterior. The roller, and consequentially exterior of the adhesive tape, can take various forms. In preferred embodiments, the roller and tape exterior have a concave, convex, undulating, dimpled or bumpy surface. The adhesive tape is made of material providing increased elongation.
US10376129B2
A dishwasher with a tub defining a treating chamber, a chassis supporting the tub, and a set of leveling assemblies mounted to the chassis. A leveling assembly can include a leveling foot having a threaded shaft and a nut having a threaded interior and a flexible or moveable portion configured to receive a portion of the threaded shaft.
US10376127B2
A dishwasher may include a tub configured to accommodate one or more items to be washed, a spray arm rotatably mounted to the tub, and configured to spray water onto the one or more items to be washed, a sump disposed at a bottom surface of the tub and configured to store water and to supply stored water to the spray arm, a fixed gear unit fixed to the tub with gear teeth arranged along an outer circumferential surface of the fixed gear unit, a rotary gear unit rotatably mounted on the spray arm and configured to engage the gear teeth of the fixed gear unit, and a link member connected to the rotary gear unit and the spray arm, where the spray arm may include, a main arm with a pair of arms, and a pair of auxiliary arms rotatably connected to the main arm.
US10376126B2
A spray arm assembly for a dishwasher, and the dishwasher are provided. The spray arm assembly includes: a spray arm base (10); a first bevel gear (20); a spray arm provided with a central water-inlet pipe (301); and a water baffling member (40). The first bevel gear (20) is connected onto the spray arm base (10) in a sleeving way. The central water-inlet pipe (301) penetrates through the first bevel gear (20). Spray apertures (302) are formed in the spray arm. A first end of the water baffling member (40) is disposed at one end of the spray arm, and a second end of the water baffling member (40) is provided with a second bevel gear (401). The water baffling member (40) is opposite to at least one of the spray apertures (302).
US10376117B2
Apparatus and methods for training and operating of robotic appliances. Robotic appliance may be operable to clean user premises. The user may train the appliance to perform cleaning operations in constrained areas. The appliance may be configured to clean other area of the premises automatically. The appliance may perform premises exploration and/or determine map of the premises. The appliance may be provided priority information associated with areas of the premises. The appliance may perform cleaning operations in order of the priority. Robotic vacuum cleaner appliance may be configured for safe cable operation wherein the controller may determine one or more potential obstructions (e.g., a cable) along operating trajectory. Upon approaching the cable, the controller may temporarily disable brushing mechanism in order to prevent cable damage.
US10376113B2
A suction unit comprising a suction apparatus, a dirt collection container, a filter device, wherein the dirt collection container is connected in terms of flow via the filter device to the suction apparatus, and a cleaning device for the filter device, which cleaning device comprises an external-air valve device, and at least one guide duct for air, which at least one guide duct has a first port which is connected in terms of fluid action to the cleaning device for the provision of external air from the at least one guide duct, a second port for the coupling of exhaust air of the suction apparatus into the at least one guide duct, and a third port which is connected in terms of fluid action to the surroundings of the suction unit, wherein air from the surroundings is configured to flow into the at least one guide duct via the third port.
US10376110B2
An apparatus for storing hand towels, the apparatus comprising a receiving portion for receiving hand towels, a first retaining member comprising a first retaining portion, the first retaining portion defining a first retaining surface for retaining the hand towels within the receiving portion, a second retaining member comprising a second retaining portion, the second retaining portion defining a second retaining surface for retaining the hand towels within the receiving portion, wherein the first and second retaining members define an opening for providing access to the hand towels and wherein an angle between the first and second retaining surfaces is less than 180 degrees.
US10376107B1
The foot-scrubbing receptacle for a shower is adapted for use with the foot of a bather. The foot-scrubbing receptacle for a shower is configured for use with a shower. The foot-scrubbing receptacle for a shower is a cleaning device. The foot-scrubbing receptacle for a shower cleanses a foot of a bather while simultaneously allowing the bather to stand erect. The foot-scrubbing receptacle for a shower comprises a shell and a cabinet. The cabinet inserts into the shell in a removable manner. To cleanse the foot, the forefoot is inserted into an open end of the foot-scrubbing receptacle for a shower where the foot is rubbed against the cleansing surface. A pedal operated soap dispenser is installed in the foot-scrubbing receptacle for a shower such that the soap may be dispensed on the foot for cleansing purposes.
US10376079B2
The neck support pillow includes a main pillow body and a neck support member releasably engaged to the main pillow body. The neck support member includes a first body portion covering at least part of a first face of the main pillow body adjacent an edge of the main pillow body for supporting the neck in use and a second body portion extending from the first portion over the edge of the main pillow body towards a second face of the main pillow body. The neck support member provides a raised surface relative to the main pillow body surface for supporting the neck in use. Neck support members and uses of the neck support members are also described.
US10376077B2
A frame apparatus for displaying a flat article and a combined frame apparatus and flat article. In one aspect, the frame apparatus comprises an annular display frame defining a rabbet, a stack positioned in the rabbet, and an annular spacer frame. The rabbet is defined by a floor and a wall, the wall comprising a first engagement portion and a second engagement portion. The annular spacer frame is coupled to the first and second engagement portions of the annular display frame by interaction between a first and second locking member of the annular spacer frame and the first and second engagement portions of the annular display frame. The first and second locking members extend into the first and second engagement portions and apply a compression force to retain a flat article between the transparent front panel and the rear panel.
US10376074B2
A bed lift mechanism that has linkages and has an actuator connected structure that is movable from a non-actuated position to two or three actuated positions. One set of linkages lifts the bed frame with the actuator connected structure moved into an associated one of the actuated positions and then push another set of linkages as the actuator connected structure is moved into another of the actuated positions. In the case where there are three actuator positions, further linkages move down a bed frame slotted bracket to initially lift the bed frame and as they reach and end of the slotted bracket as the actuator connected structure is moved to a different actuator position, the one set of linkages pull together to lift the bed frame vertically.
US10376064B1
An adjustable lifting structure for a chair back contains: a first adjustment unit and a second adjustment unit. The first adjustment unit mates with the second adjustment unit via a transmission cable, and the first adjustment unit includes a longitudinally hollow chamber for slidably accommodating a guide plate connected on a seat. The first adjustment unit includes a body and two covering assemblies. A drive block includes a locking space, a slit, two deformable chambers, a trough, and two projections. The guide plate includes a conducting element and a rail having multiple teeth and multiple cutouts. The second adjustment unit includes an adjuster, an operation cavity, a first aperture, a connecting room, and two stop segments. A transmission cable includes a first transmitting segment and a second transmitting segment, wherein the first transmitting segment has a first defining portion, and the second transmitting segment has a second defining portion.
US10376058B2
A system and method are disclosed for motorized modular shelf organization. The system and method includes a gondola rack with a plurality of longitudinal shelves which engage with an upright support on the gondola rack, and are capable of moving vertically via a motorized element. The gondola rack also includes at least two support arms which are capable of grasping the plurality of longitudinal shelves and moving the plurality of longitudinal shelves laterally and vertically so that the longitudinal shelves may swap positions with another shelf.
US10376056B2
A device for mounting a rear wall on a movable furniture component of a piece of furniture, in particular on a drawer, with the movable furniture component including a rear wall and a drawer sidewall unit. The device is characterized in that the device is for arrangement between a rear wall holder extending on the drawer sidewall unit in a plane of the rear wall and the rear wall, and the device has an engagement mechanism for engagement in the rear wall holder.
US10376053B2
A drawer includes having a drawer side wall, a drawer wall which is produced from a wood material, and having a fitting part (14) which is attached to one of the two end faces of the drawer wall and by which the drawer wall is connected to the drawer side wall. The drawer side wall has a recess for receiving the fitting part, and the drawer wall produced from the wood material, projects into the recess in the drawer side wall by way of that end face which is fitted with the fitting part.
US10376049B2
A locker includes a pair of spaced-apart upstanding sidewalls, at least one member extending between the sidewalls, the member having a pair of ends, a tongue formed on each end of the member, a groove formed in each sidewall, each groove dimensioned to receive the tongue formed in the end of the member; and a metallic reinforcing member secured to each of the member and the sidewall at an intersection thereof.
US10376048B2
A shelving system having a top, bottom and intermediate shelves mounted on vertical supports. The intermediate shelves are mounted on adjustable brackets that permit individual removal of the intermediate shelves without disturbing the top and bottom shelves. The adjustable brackets comprise at one end a pin that is adapted to be inserted into a series of apertures formed along the length of each support. Opposite the pin, a mounting member is sized and shaped to receive a corner of each shelf. A stop is formed on the bracket between the pins and mounting member.
US10376044B2
The present invention provides a smart, electronic desk to facilitate and improve interactive learning. The desk comprises a student desk having a table, a computer such as a tablet having a touch-screen interface, and a document camera all integrated together. The interface displays electronic information to the student and provides a graphic user interface that allows the student to interact with programs or apps through graphical icons and visual indicators. The document camera, also known as a visual presenter, captures images and/or video of documents or other objects placed on the table. The computer comprises a bilateral communications interface to communicate information such as, but not limited to video, between the computer and optional document camera at the electronic desk, and any number of other computers.
US10376040B2
A fluid supply apparatus with leakage protection. The apparatus includes a housing defining a storage cavity having a total volume including a fluid portion and a gas portion. The storage cavity extends along a cavity axis from a first end to a second end. A capillary member is fluidly coupled with the fluid. A plurality of vent apertures are formed into the housing, each forming a passageway between the storage cavity and an external atmosphere and each configured such that the fluid cannot flow through the vent apertures at ambient temperature and pressure equilibrium between the storage cavity and the external atmosphere. The vent apertures may be located and arranged on the housing such that irrespective of vertical and angular orientation of the housing relative to a gravitational vector at least one of the vent apertures is in spatial communication with the gas.
US10376036B2
The invention relates to a cosmetic product applicator (10) with a core (12) having a first end, called proximal end (13), and a second free end, called distal end (16), and a plurality of protuberances (30) protruding from the core (12). The protuberances (30) are molded with the core (12) and are arranged in a plurality of rows extending in the extension direction (Y) of a sleeve (14) extending the core (12). The free ends of said protuberances (30) form two separate enclosures, a first of said enclosures having an outer bulk smaller than that of the second enclosure (E2). The number of rows, called first rows, forming the first enclosure being smaller than the number of rows, called second rows, forming the second enclosure (E2). The invention also related to an associated applicator assembly.
US10376032B2
A system for providing securement of a plurality of secure portable encasements including one or more encasements each configured to engage, and subsequently disengage, inseparable interaction with a common docking unit; and one or more common docking units.
US10376012B2
A safety helmet with retractable brim comprising a helmet shaped body having a slot presented on a downward facing surface of a front section. The safety helmet includes a brim that translates within the slot between a retracted and a downward configuration. In the retracted configuration the brim is received within the slot. In the downward configuration the second end of the brim does not extend beyond the forward facing surface of the helmet. A pivoting element is configured to pivotally couple the brim proximate to the lip of the slot. The pivoting element allows the brim to move between the downward configuration and a forward configuration. In the forward configuration the brim extends outward beyond a forward facing surface of the helmet shaped body. A first locking element is configured to maintain the brim in the forward configuration.
US10376008B2
A computer-implemented method for designing a virtual garment or upholstery in a three-dimensional scene comprising the steps of: a) providing a three-dimensional manikin, a set of pattern parts of said virtual garment or upholstery and a set of seam specification; b) receiving from a user a plurality of declarations of assembly tasks (A, B, C, D1, D2, E1, E21, E22, F2) for assembling the garment or upholstery; c) receiving from the user at least a declaration of a partial ordering relationship between two or more of said assembly tasks; d) executing said tasks according to said partial ordering relationship, each task changing a state of the garment or upholstery under assembly; characterized in that it further comprises a step of: e) while executing the tasks, generating a tree data structure comprising nodes linked by directed arcs, each node being associated to a state of the garment or upholstery and each arc being associated to an assembly task. A computer program product, non-volatile computer-readable data-storage medium and Computer Aided Design system for carrying out such a method. Application of the method to the manufacturing of a garment or upholstery.
US10376005B2
The present invention provides a portable vacuum cleaning apparatus for use on an opening in a combustion chamber. The portable vacuum cleaning apparatus includes: a shield with one or more connectors each independently configured to provide an air tight seal with an opening of a combustion chamber; a first aperture fitting protruding through the shield and connected to a first air hose with an air source and a second air hose with a nozzle; a second aperture fitting protruding through the shield and connected to a vacuum source, a third aperture fitting protruding through the shield and connected to a glove. Methods of using and systems for vacuum cleaning a combustion chamber are also provided.
US10375992B2
Certain aspects of present invention relate to an electronic cigarette having temper-proof locking mechanisms. In certain embodiments, the electronic cigarette may include: an electronic cigarette body, a temper-proof mouthpiece connector locking mechanism threadedly connected to electronic cigarette body, and a temper-proof power connector locking mechanism threadedly connected to electronic cigarette body. When a user pushes temper-proof mouthpiece connector locking mechanism towards electronic cigarette body, temper-proof mouthpiece connector locking mechanism is locked such that the user is able to remove a mouthpiece connector from electronic cigarette body to refill e-liquid for the electronic cigarette. When user pushes temper-proof power connector locking mechanism towards electronic cigarette body, temper-proof power connector locking mechanism is locked such that user is able to remove a power connector from electronic cigarette body to replace a vaporizer, a heater for the vaporizer, and e-liquid storage medium of the electronic cigarette.
US10375991B2
An electronic inhalation device includes an outer housing extending in a longitudinal direction, an air inlet, an outlet, a formulation, and an abrasive element, which contacts a surface of the formulation. The abrasive element is configured to generate a particle cloud from the formulation by removing particles from the formulation and entraining the particles in an air flow.
US10375976B2
A flavor-enhanced beverage includes an added amount of pyroglutamic acid or a salt thereof. The pyroglutamic acid may be in the form of L-pyroglutamic acid, D-pyroglutamic acid, monosodium L-pyroglutamate, monosodium D-pyroglutamate, or a mixture thereof. Both ready-to-drink beverages (such as fruit juices, vegetable juices, coffee, tea, carbonated soft drinks, energy drinks, sports drinks, dairy, and low calorie drinks) as well as concentrated beverages used for the preparation of ready-to-drink beverages benefit from the addition of the pyroglutamic acid. The addition to a beverage product may be in an amount of up to about 3,000 ppm of pyroglutamic acid or a salt thereof, in concentrates, or up to about 300 ppm in ready-to-drink beverages.
US10375974B2
A protein fraction and an oxidation stable fat fraction are recovered from meat trimmings. The trimmings are comminuted, mixed with a food grade acid at pH 3.6 to 4.4 to form a liquid protein fraction and a solid fat fraction. The liquid fraction is mixed with a food grade alkali to precipitate the protein. A myoglobin rich fraction is recovered from the protein fraction and mixed with the precipitated protein.
US10375968B2
The invention is an improved process and system for producing a shaped snack chip. A shaping oven, which uses a chain edge conveyor having transverse slats with at least one spring affixed to the slats, is used to convert dough pieces into shaped pre-forms, which can optionally be further dehydrated to form shaped snack chips.
US10375965B2
The present invention, which addresses the problem of providing a composition that has an excellent effect of controlling plant disease, provides a plant disease control composition that includes the Bacillus strain APM-1 (New strain of Bacillus, APM-1) which is deposited under ATCC Accession No. PTA-4838 and at least one compound selected from the group consisting of ethaboxam, tolclofos-methyl, metalaxyl, fludioxonil, and a carboxamide compound represented by formula (1).
US10375963B2
The present disclosure relates to the use of alkali metal salts and preferably lithium chloride for treatment of Varroa destructor infestation of honey bees.
US10375961B2
The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
US10375953B2
A synthetic polymer film (34A) having a surface which has a plurality of raised portions (34Ap), (34Bp), wherein a two-dimensional size of the plurality of raised portions (34Ap), (34Bp) is in a range of more than 20 nm and less than 500 nm when viewed in a normal direction of the synthetic polymer film (34A), (34B), the surface having a microbicidal effect. The synthetic polymer film (34A), (34B) includes a urethane resin and a silicone oil, and the silicone oil has a HLB value of not less than 14 and not more than 18.
US10375938B2
A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.
US10375931B2
A method for creating a video for pets, comprising: creating visual content for the video; and creating auditory content for the video, wherein the auditory content comprises: a musical arrangement that has a relaxing effect on dogs, the musical arrangement characterized by a tempo in the range of 50 to 70 beats per minute (BPM), and one or more sounds that have a stimulating effect on dogs.
US10375929B2
A clip-style equine twitch device comprising a clip head and in-line tether holes, each threaded with a section of rope or cord to form an adjustable loop that can be applied to the horse and then securely clipped to an anchor point, and a method of use thereof.
US10375924B2
A cage for monitoring an experimental animal is disclosed. The cage may include one or more walls that enclose a living space for at least one experimental animal. At least one of the one or more walls may include a first material that is a plastic material. The cage may further include a window that is transparent to a band of infrared radiation that is within the range of from about 3 μm to about 14 μm in wavelength. The transparent window may have an inner side exposed to the living space that includes a second material that is substantially non-toxic to the at least one experimental animal.
US10375922B2
The invention provides seed and plants of pepper hybrid DR2179PB and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of pepper hybrid DR2179PB and the parent lines thereof, and to methods for producing a pepper plant produced by crossing such plants with themselves or with another pepper plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US10375918B1
A novel soybean variety, designated 5PZUE24 is provided. Also provided are the seeds of soybean variety 5PZUE24, cells from soybean variety 5PZUE24, plants of soybean 5PZUE24, and plant parts of soybean variety 5PZUE24. Methods provided include producing a soybean plant by crossing soybean variety 5PZUE24 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PZUE24, methods for producing other soybean varieties or plant parts derived from soybean variety 5PZUE24, and methods of characterizing soybean variety 5PZUE24. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PZUE24 are further provided.
US10375914B1
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH268120. The invention thus relates to the plants, seeds and tissue cultures of the variety CH268120, and to methods for producing a corn plant produced by crossing a corn plant of variety CH268120 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH268120.
US10375913B1
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH341398. The invention thus relates to the plants, seeds and tissue cultures of the variety CH341398, and to methods for producing a corn plant produced by crossing a corn plant of variety CH341398 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH341398.
US10375908B1
A novel sorghum variety designated XSW4801 and seed, plants, plant parts and plant cells thereof are produced from a cross of inbred sorghum varieties. Methods for producing a sorghum plant comprise crossing hybrid sorghum variety XSW4801 with another sorghum plant. Sorghum variety XSW4801, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of sorghum variety XSW4801 are provided. Methods for producing a sorghum plant containing in its genetic material one or more traits introgressed into sorghum variety XSW4801 include one or both of backcross conversion and transformation of one or both inbred parents. The sorghum seed, plants and plant parts produced thereby are described.
US10375902B2
The battery-powered blower includes a housing assembly including a first housing portion having a first inner surface, a second housing portion having a second inner surface, and connected to the first housing portion, and a third housing portion connected to the second portion. The third housing portion has a side outer surface configured to receive a battery. The battery is mountable to the side outer surface of the third housing portion. The second housing portion in connection with to the first housing portion forms an inner chamber therebetween. A fan is provided in the inner chamber to facilitate airflow through the housing assembly and out an outlet, and a motor is provided intermediate to the second housing portion and the third housing portion. The center of gravity with respect to the overall blower is provided proximate to a handle portion.
US10375901B2
A blower/vacuum being interchangeable between a blower configuration and a vacuum configuration is provided. The blower/vacuum includes a blower assembly attachable to a base in the blower configuration and a vacuum assembly attachable to the base in the vacuum configuration. The blower/vacuum includes a fan member that has both a first fan and a second fan integrally formed together, wherein the first fan is utilized to generate air flow in the blower configuration and the second fan is utilized to generate air flow in the vacuum configuration.
US10375898B2
One variation of a method for automating transfer of plants within an agricultural facility includes: dispatching a loader to autonomously deliver a first module—defining a first array of plant slots at a first density and loaded with a first set of plants at a first growth stage—from a first grow location within an agricultural facility to a transfer station within the agricultural facility; dispatching the loader to autonomously deliver a second module—defining a second array of plant slots at a second density less than the first density and empty of plants—to the transfer station; recording a module-level optical scan of the first module; extracting a viability parameter of the first set of plants from features detected in the module-level optical scan; and if the viability parameter falls outside of a target viability range, rejecting transfer of the first set of plants from the first module.
US10375895B2
A machine for cutting the tips of the leaves off agave plants to prepare the plants for the subsequent removal of the core. The machine includes a chassis defining a platform having: a rear end having a structural frame supporting arms that project rearwards, wheel rims that rest on the ground being secured to said arms; a front end having a structural frame having arms extending frontwards, a tractor-coupled drawbar being secured to said arms; and an arm that connects to the power take-off and is secured in the upper part of the structural frame. The machine includes a supporting base which can slide under the action of hydraulic elements, and is mounted on a pair of parallel rails and is arranged transversely across the platform. Additionally, the machine includes a hydraulic system with control inputs, actuated by the operator.
US10375894B2
An agricultural baler has a shaft, and a flywheel connected to the shaft, and a brake system for holding or for stopping the flywheel. The brake system may be of at least one of the drum-type and of the caliper-type. The caliper-type has a brake disc and a brake caliper. The brake disc may be mounted on the flywheel, or on the shaft. The brake system may have an adjustable braking force. The disc brake may be manually or hydraulically activated. The brake system may be remotely activated from a tractor.
US10375885B2
A system of chopping and spreading residue for an agricultural combine comprises a chopper disposed in front of a residue accelerator at the rear of an agricultural combine. The chopper is disposed to receive crop residue from a threshing and separating section of the combine and to chop that residue into smaller portions, the residue accelerator is disposed behind the chopper to receive the chopped crop residue from the chopper, and to accelerate it.
US10375878B2
Systems and methods for implementing a plot in a field based on the location of a marker placed in an application prescription map prior to a crop input application operation are disclosed. The plot defines a plot region. The plot region is defined during the crop input application operation based on the marker location.
US10375876B2
An air seeding system and method includes a manifold mounted across a plurality of row planter units. Electric motors are mounted on the manifold and are operatively connected to the seed meters. A microprocessor or controller adjusts the speed of the motors in response to field data input so as to adjust the rate of seed dispensement to achieve desired plant population. The motor speeds can be adjusted on the fly, without stopping the air seeder. The system senses ground speed, senses the raised and lowered positioned of the row planter units, and senses any blockage of the row planter units. The motors eliminate the need for a ground drive wheel.
US10375871B1
A powerful very strong commercial grade hand operated tool for removing weeds intact from a standing position. The tool includes cushions on the handles that are firm and pleasant to use and are replaceable. There are bolts contained in the retaining device that are also replaceable. A completely serviceable tool. There is an ejector disc contained within the retaining device on the bottom end used to expel the weed debris from the tool into a refuse container, this action is spring loaded from the top end of the tool.
US10383270B2
An object of the present disclosure is to provide a component crimping device and a component crimping method that make it possible to improve accuracy of attaching a component onto a substrate by preventing the component from being excessively elongated due to rapid thermal expansion when the component is pressed against the substrate. A lower surface side of a substrate-side terminal part of a substrate held by a substrate holding table is supported by a support, a component placed on a placing table is picked up by a crimping head while heating the component, the component is compressed against a compressing table so as to be elongated, and then the component is pressed against the substrate-side terminal part.
US10383266B2
Apparatuses, systems and methods associated isolation to avoid interference from wireless signals in a circuit assembly are disclosed herein. In embodiments, a wireless signal isolation assembly may include an outer shield enclosure, the outer shield enclosure to enclose circuitry of a circuit board that is to be isolated from interference, wherein the outer shield enclosure is to attenuate wireless signals. The wireless signal isolation assembly may further include a first inner shield enclosure located within the outer shield enclosure, the first inner shield enclosure to enclose first circuitry, wherein the first inner shield enclosure is to attenuate wireless signals. The wireless signal isolation assembly may further include a second inner shield enclosure located within the outer shield enclosure, the second inner shield enclosure to enclose second circuitry, wherein the second inner shield enclosure is to attenuate wireless signals. Other embodiments may be described and/or claimed.
US10383263B2
An inverter system control (ISC) module is provided. The ISC module includes a power module defining a coolant channel for receiving a coolant, and a capacitor assembly disposed adjacent to the power module. The capacitor assembly includes a housing, a potting material disposed within the housing, and a plurality of power sources disposed within the potting material. The capacitor assembly further includes a cooling bar extending within the potting material between the power sources, and further extending out of the potting material and into the power module.
US10383262B2
The power conversion device of the invention includes: a cooling unit that is a prism, the interior of which is hollow, and that has a refrigerant inlet portion and a refrigerant outlet portion the cooling unit having in the interior thereof a refrigerant channel through which a refrigerant flows from the refrigerant inlet portion towards the refrigerant outlet portion; electronic devices that are respectively disposed on three or more surfaces on the outside of side surfaces of the cooling unit, excluding a refrigerant inlet surface, in which the refrigerant inlet portion is disposed, and a refrigerant outlet surface, in which the refrigerant outlet portion is disposed, the electronic devices being cooled by boiling of the refrigerant; and a hollow outer case 4 that covers the electronic devices.
US10383256B2
As an air mover assembly is translated from a first orientation to a second orientation, a first roller and a second roller translate about at least one rail such that the a frame and a door maintain a position relative to the direction of the force of gravity.
US10383255B2
An edge sealing heat-dissipating film includes a heat radiation emitting film, a metal film and a heat radiation receiving film. The heat radiation emitting film has a first opening. The metal film is disposed to the heat radiation emitting film and the metal film has a second opening. The second opening is positioned corresponding to the first opening. The heat radiation receiving film is disposed to the metal film and the heat radiation receiving film has a third opening. Wherein, the shape of the heat radiation emitting film is the same as the shape of the heat radiation receiving film. And the area of the metal film is slightly smaller than the area of the heat radiation receiving film and the heat radiation emitting film. Therefore, the outer periphery of the heat radiation emitting film and the outer periphery of the heat radiation receiving film could be closely bonded together.
US10383254B2
An electronic device is provided. The electronic device includes a heat source, a heat-conductive member and a heat-dissipating sheet. The heat-conductive member includes a recess, wherein the recess is thermally connected to the heat source. The heat-dissipating sheet is attached to the heat-conductive member, wherein the heat-dissipating sheet covers the recess.
US10383250B1
A network-attachable rack-mountable computing device is housed within a shippable enclosure and is configured to mount in a rack. The device may be initialized (e.g., prepared to receive data, and an updateable electronic shipping display set to a shipping destination) by a service provider and shipped, in accordance with a displayed destination address, as a self-contained shipping unit. The device may be coupled with other devices via coupling mechanisms included in an enclosure of the device and may be mounted in a rack at a destination via mounting brackets included in the enclosure of the device. The device may be installed onto a network at the destination and loaded with data. When the device is received back at the service provider, the data is transferred from the device to a service provider storage facility, wiped of data, and prepared to be sent out again.
US10383249B1
A server comprises case, first storage module, second storage module and at least one third storage module. The case comprises base plate and two side plates. The base plate has first side, second side and fourth side. The first side is opposite to the second side. The third side and the fourth side are located between the first side and the second side, and the third side is opposite to the fourth side. Two side plates respectively stand on first side and second side. The first storage module is fixed to case and located between third side and fourth side. The second storage module is located between first storage module and fourth side and movably disposed on the case. The at least one third storage module is located between the second storage module and the fourth side and movably disposed on the case.
US10383244B2
An electronics enclosure assembly includes a housing comprising a first chamber, a second chamber, and a first wall coupled between the first chamber and the second chamber. The electronics enclosure assembly also includes at least one plate coupled to the housing. The first wall and the plate combine to define a first channel extending through the first wall. The first channel couples the first chamber in communication with the second chamber.
US10383241B2
A capping member is provided. The capping member is adapted to a flexible display panel. The capping member includes a first side wall, a second side wall opposite to the first side wall, a plurality of holes located between the first side wall and the second side wall. The first side wall is configured to be coupled to a side of the flexible display panel. The first side wall and the second side wall are bendable with the side of the flexible display panel and a configuration of each of the plurality of holes are changeable during bending the first side wall and the second side wall. A housing assembly and an electronic device are also provided.
US10383225B1
Aspects of the disclosure are directed to apparatuses and methods involving an electrical connector and methods thereof. As may be consistent with one or more embodiments, an interposer includes respective barrier layers having barrier material that is coplanar with, and laterally surrounds, traces having connected via pads. Vias connect pads of stacked pairs of the traces in different ones of the barrier layers. The traces vary in width along their respective lengths. The barrier material is offset from each trace by a continuous gap having a length extending around the trace, with the gaps extending around each stacked pair being offset from one another along the majority of their respective lengths.
US10383222B2
To provide a surface-treated copper foil that is excellent in adhesiveness to an insulating substrate at ordinary temperature, and is capable of suppressing the formation of blister on application of a thermal load of reflow soldering to a copper-clad laminate board constituted by the copper foil. A surface-treated copper foil having a surface-treated surface, the surface-treated copper foil satisfying one or more of the following conditions (1) to (3): by an XPS measurement at a depth after sputtering from the surface-treated surface for 0.5 min at a rate of 1.1 nm/min (SiO2 conversion), (1) the N concentration is from 1.5 to 7.5 atomic %; (2) the C concentration is from 12 to 30 atomic %; and (3) the Si concentration is 3.1 atomic % or more and the O concentration is from 40 to 48 atomic %.
US10383220B2
A ceramic substrate and a method for production thereof are provided, in which the ceramic substrate includes a composite of: a first ceramic layer including Sr anorthite and Al2O3 or an oxide dielectric with a dielectric constant higher than that of Al2O3; and a second ceramic layer including Sr anorthite and cordierite and having a dielectric constant lower than that of the first ceramic layer.
US10383218B2
A display device includes: a display module including a display panel which displays an image; a main driving unit on a side of the display module; a first auxiliary driving assembly hinge-connected to a first side of the main driving unit; and a second auxiliary driving assembly hinge-connected to a second side of the main driving unit opposite to the first side thereof. The main driving unit includes: a fixing bracket attached to the side of the display module; a first main actuator hinge-connected to a first side of the fixing bracket; and a second main actuator hinge-connected to a second side of the fixing bracket opposite to the first side thereof.
US10383214B2
An electronic device capable of supplying a large current to a circuit pattern containing conductive nanoparticles includes a substrate, a region provided on the substrate, configured to mount an electronic component therein, a first circuit pattern placed within the region and electrically connected to the electronic component, a second circuit pattern connected to the first circuit pattern and configured to supply current to the first circuit pattern from outside of the region. At least a part of the first circuit pattern includes a layer obtained by sintering conductive nanosized particles with a diameter of less than 1 μm. The second circuit pattern is thicker than the first circuit pattern.
US10383202B2
Technology is described for electronically aligning a central ray of an x-ray tube to a radiation detector. In an example, an x-ray system includes an x-ray tube and a tube control unit (TCU). The x-ray tube includes a cathode that includes an electron emitter configured to emit an electron beam, an anode configured to receive the electron beam and generate x-rays with a central ray from electrons of the electron beam colliding on a focal spot of the anode, and a steering magnetic multipole between the cathode and the anode that is configured to produce a steering magnetic field from a steering signal. At least two poles of the steering magnetic multipole are on opposite sides of the electron beam. The TCU includes at least one steering driver configured to generate the steering signal. The TCU is configured to convert an offset value to the steering signal.
US10383199B2
A lighting system utilizes intelligent system elements, such as lighting devices, user interfaces for lighting control or the like and possibly sensors. The system also has a data communication network. Some number of the intelligent lighting system elements, including at least two of the lighting devices, also support wireless communication with non-lighting-system devices at the premises. Each such element has a communication interface system configured to provide a short range, low power wireless data communication link for use by non-lighting-system devices at the premises in proximity to the respective intelligent system element. Also, in such an element, the processor is configured to control communications via the communication interface system so as to provide access to the data network and through the data network to the wide area network outside the premises for non-lighting related communications of the non-lighting-system devices.
US10383195B2
A surgical lamp for illuminating a surgical field on a human body is provided. The surgical lamp comprises a control device (4), a lamp body (1) comprising several illuminants (3) with one respective light ray (I, II, II′) directed to the surgical field, and a 3D sensor (6) for detecting a spatial position of at least one object, and a device for switching on and off and dimming the illuminants (3), wherein the control device (4) controls the devices for switching on and off and dimming the illuminants (3), the 3D sensor (6) detects the spatial positon of the at least one object and transmits corresponding data to the control device (4), and the control device (4) is configured to control the illuminants (3) according to the spatial position of the at least one object.
US10383188B2
An outdoor luminaire comprises a housing adapted to be mounted on an outdoor structure, an input disposed in the housing that receives AC power, and at least one rectification element coupled to the input and which produces rectified AC electrical power comprising a plurality of cycles. At least one LED driver circuit is coupled to the at least one rectification element and a plurality of LEDs is coupled to the at least one LED driver circuit. The LEDs are turned on at different points during each of the plurality of cycles and together develop an output level of at least about 2000 lumens.
US10383179B2
A crucible device with temperature control design includes a crucible body, an induction coil unit, a nozzle flange body and a melt delivery tube and a temperature control unit. The induction coil unit surrounds the crucible body, provides a heat source during use, and is configured to enable a metal material to melt and produce a melt having a melting skull. The melt delivery tube is communicated via the nozzle flange body to a bottom of the crucible body and is configured to deliver the melt from the crucible body. The temperature control unit includes a microprocessor, a heater and a temperature sensor which are electrically coupled to each other, and are configured to control a curve of the melting skull to drop to a preset position.
US10383169B2
A terminal connection management method of the present invention comprises the steps of setting a signal timer corresponding to a signal bearer of a terminal and a data timer corresponding to a data bearer, confirming whether the signal timer and the data timer have expired, and disconnecting from the terminal if both of the signal timer and the data timer have expired.
US10383161B2
In various aspects of this disclosure, a communication terminal device may be provided. The communication terminal device may include a cellular wide area radio communication technology circuit. The cellular wide area radio communication technology circuit may be configured to provide a communication according to a cellular wide area radio communication technology. The communication terminal device may further include a circuit. The circuit may be configured to provide a direct communication terminal device to communication terminal device communication bypassing a radio access network according to information received via the radio access network. The communication terminal device may further include a message generator. The message generator may be configured to generate a message to transmit to a base station. The message may include at least one message field specifying information about at least one capability to provide the direct communication terminal device to communication terminal device communication of the communication terminal device. The message may be generated for a network communication protocol.
US10383160B2
The present disclosure discloses a data processing method, apparatus, and device. The method includes: sending, by a user equipment UE, updated metadata; obtaining a metadata index value corresponding to the updated metadata; and broadcasting, by the UE, the obtained metadata index value.
US10383157B2
An information handling system includes a management system and first and second first baseboard management controllers (BMCs). The first BMC includes a first wireless interface, and is coupled via a first wired interface to the management system. The second BMC includes a second wireless interface, and is coupled via a second wired interface to the management system. The information handling system detects that the BMC has become uncoupled from the management system via the first wired interface, establishes a wireless link between the first wireless interface and the second wireless interface in response to detecting that the first BMC has become uncoupled from the management system, and provides management between the first BMC and the management system via the second wired interface and the wireless link.
US10383156B2
A system and method of operating a mobile hotspot at a vehicle. The system involves use of a vehicle that includes a battery and a charging port, wherein the charging port connects the vehicle to an external power source and is electrically connected to the battery to provide the battery with electrical power from the external power source when connected; a wireless access point, wherein the access point is powered by the battery in the vehicle and wherein the access point wirelessly provides Internet access to one or more wireless devices located in or within a proximity of the vehicle; and a controller, wherein the controller enables operation of the access point while the vehicle is powered off when the vehicle is connected to the external power source via the charging port.
US10383151B2
Disclosed are narrowband (NB)-physical random access channel (PRACH) techniques for NB-long term evolution (LTE) systems supporting cellular internet of things (CloT) and machine-type communications (MTC) deployments. Apparatus and methods are described for generating, transmitting, or receiving an NB-PRACH defined by an NB-PRACH physical structure and an NB-PRACH numerology.
US10383144B2
A method includes transmitting, at an access point configured to transmit data over an unlicensed band, a single message prior to transmitting data over a channel of the unlicensed band. The method further includes receiving, at the access point, a plurality of responses from a plurality of user equipment acknowledging the single message in response to the single message.
