公开(公告)号：US11738157B2

公开(公告)日：2023-08-29

申请号：US16759274

申请日：2018-10-26

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque Chowdhury

IPC: A61M5/42 ,  A61M5/24 ,  A61M5/32 ,  A61M5/46

CPC classification number: A61M5/425 ,  A61M5/24 ,  A61M5/329 ,  A61M5/3287 ,  A61M5/3298 ,  A61M5/46 ,  A61M2205/13 ,  A61M2205/3331

Abstract: The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

公开(公告)号：US11213483B2

公开(公告)日：2022-01-04

申请号：US16506850

申请日：2019-07-09

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque Chowdhury

IPC: A61K9/00 ,  B29C48/09 ,  A61K38/17 ,  A61M37/00 ,  A61M5/32 ,  B29C39/02 ,  B29C41/02 ,  B29C43/02 ,  B29C43/36 ,  B29K1/00 ,  B29K105/00 ,  B29L31/00

Abstract: A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.

公开(公告)号：US20210290489A1

公开(公告)日：2021-09-23

申请号：US16317393

申请日：2017-07-12

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque CHOWDHURY

IPC: A61J1/20

Abstract: It is known to deliver drugs through the skin, i.e. transdermally, by using a needle that is used in conjunction with a device.
A device (10) comprises a device body (12) which has an opening (14) for receiving a needle assembly (100) in use. The device also comprises a loading mechanism (16) which is moveable in use to receive the needle assembly (100) via the opening (14) and secure the needle assembly (100) relative to the device body (12). The loading mechanism (16) is configured to receive and secure the needle assembly (100) upon force exerted on the loading mechanism (16) in a single direction (FD1).

公开(公告)号：US11278678B2

公开(公告)日：2022-03-22

申请号：US16305877

申请日：2017-05-30

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque Chowdhury

IPC: A61M5/46 ,  A61M5/315 ,  A61M5/42 ,  A61M5/32 ,  A61M5/20 ,  A61M5/142 ,  A61M5/158

Abstract: A needle delivery device (10) comprises a needle assembly (4, 5), a drive mechanism (2, 3) and a contact member (6). The drive mechanism (2, 3) includes a drive member (2) which is linearly moveable upon rotation of the drive member (2). The contact member (6) is positioned between and abutting the needle assembly (4, 5) and the drive member (2). The contact member (6) is configured to provide only linear motion to the needle assembly (4, 5) upon rotation of the drive member (2) so as to drive movement of the needle assembly (4, 5) between a distal and proximal direction relative to the needle delivery device (10).

公开(公告)号：US20210369983A1

公开(公告)日：2021-12-02

申请号：US16322480

申请日：2017-07-28

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque CHOWDHURY

IPC: A61M5/46 ,  A61M5/158

Abstract: A needle delivery device (10; 100) comprises a device body (12) that has an opening (14) formed on a delivery surface (16) of the device body (12). The needle delivery device (10; 100) also includes a drive mechanism (28) which is configured to, in use, drive a needle (20; 120), at least a portion (22) of which is flexible, along a needle path (30) towards the opening (14). The needle path (30) changes direction as it reaches the opening (14). Furthermore, the needle delivery device (10; 100) includes a rigid support member (32) that is fixedly secured to the device body (12) at the opening (14). The rigid support member (32) is configured to guide the needle (20) as it leaves the opening (14) so as to prevent buckling of the needle (20; 120). The device also comprises a vial (40) for containing a pharmaceutical composition, the vial being in fluid communication with one end of the needle, wherein the vial is moveable in tandem with the needle as the needle is driven along the needle path.

公开(公告)号：US10675453B2

公开(公告)日：2020-06-09

申请号：US15710309

申请日：2017-09-20

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque Chowdhury

IPC: A61M37/00

Abstract: A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

公开(公告)号：US10646703B2

公开(公告)日：2020-05-12

申请号：US14785277

申请日：2014-04-23

Applicant: NDM Technologies Limited

Inventor： Dewan Fazlul Hoque Chowdhury

IPC: A61M37/00 ,  A61K9/00

Abstract: This invention relates to a device that uses microneedles to create pores in the skin of a subject and delivers the drug transdermally by inserting it into the pore as a solid or semi-solid mass alongside each needle. The device is sufficiently flexible to allow relative movement of the needle and the drug mass apart from one another. Preferably a chamber holding the drug mass comprises a relatively rigid wall to ensure that the drug remains aligned close to the needle, while an adjacent chamber holding the needle comprises a relatively flexible wall to allow lateral movement of the needle as the drug is inserted alongside it.

公开(公告)号：US20190240410A1

公开(公告)日：2019-08-08

申请号：US16319042

申请日：2017-07-12

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque CHOWDHURY ,  Paul BURNETT

IPC: A61M5/24 ,  A61M5/142 ,  A61M5/20

CPC classification number: A61M5/24 ,  A61M5/14244 ,  A61M5/20 ,  A61M2005/14252 ,  A61M2005/1585 ,  A61M2005/2006 ,  A61M2005/206

Abstract: It is known to deliver drugs through the skin, i.e. transdermally, by using a needle that is used in conjunction with a device. A device (10), for delivering a needle (110) to an injection site, comprises a rotation member (12) which is rotatable about a reference axis (Aref), the reference axis (Aref) being the central axis of the rotation member (12). The device (10) further including a needle support member (14) which is configured to support a needle (110) in use. The needle support member (14) being fixedly secured to the rotation member (12) such that rotation of the rotation member (12) results in the needle (110) supported by the needle support member (14) in use being delivered to an injection site. The central axis (AOffSet) of the needle support member (14) is parallel to the reference axis (Aref) such that the needle support member (14) is offset from the rotation member (12).

公开(公告)号：US20190125984A1

公开(公告)日：2019-05-02

申请号：US16305877

申请日：2017-05-30

Applicant: NDM TECHNOLOGIES LIMITED

Inventor： Dewan Fazlul Hoque CHOWDHURY

IPC: A61M5/46 ,  A61M5/20 ,  A61M5/315

Abstract: A needle delivery device (10) comprises a needle assembly (4, 5), a drive mechanism (2, 3) and a contact member (6). The drive mechanism (2, 3) includes a drive member (2) which is linearly moveable upon rotation of the drive member (2). The contact member (6) is positioned between and abutting the needle assembly (4, 5) and the drive member (2). The contact member (6) is configured to provide only linear motion to the needle assembly (4, 5) upon rotation of the drive member (2) so as to drive movement of the needle assembly (4, 5) between a distal and proximal direction relative to the needle delivery device (10).

公开(公告)号：US10239236B2

公开(公告)日：2019-03-26

申请号：US14913289

申请日：2014-08-18

Applicant: Dewan Fazlul Hoque Chowdhury

Inventor： Dewan Fazlul Hoque Chowdhury

IPC: A61M37/00 ,  B29C31/00

Abstract: Microneedle devices have projections that are generally sharp and elongated and designed to disrupt the upper layer of the skin, cause micro-indentations, or pierce the skin. High density arrays are produced using micro-fabrication or micro-molding techniques. The assembly of individual needles does not lend itself to the production of high density arrays. A method of forming microneedle arrays is disclosed which comprises attaching a plurality of microneedles to a substrate, and building up a 2-dimensional microneedle array by wrapping layers of the substrate around a core or folding the layers repeatedly back upon themselves. The arrays are capable of needle densities with a pitch within the range of needle radius plus several micrometers to millimeters.