公开(公告)号：USD886597S1

公开(公告)日：2020-06-09

申请号：US29663851

申请日：2018-09-19

Applicant: ORBIT BIOMEDICAL LIMITED

Designer： Chaley J. Larson ,  Michael Cannamela ,  William H. Cagney ,  Gordon Kosovan ,  Elaine Hughes ,  Maria Ficchi ,  Kostadinka Lilova

公开(公告)号：US10478553B2

公开(公告)日：2019-11-19

申请号：US15438918

申请日：2017-02-22

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Thomas E. Meyer ,  Benjamin L. Ko ,  Isaac J. Khan ,  Daniel W. Price ,  Brendan J. Oberkircher ,  Michael F. Keane

IPC: A61M5/158 ,  A61F9/00 ,  A61M5/168 ,  A61M5/32

Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.

公开(公告)号：US10206852B2

公开(公告)日：2019-02-19

申请号：US15380718

申请日：2016-12-15

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Chaley J. Larson ,  Kostadinka Lilova ,  Michael Cannamela ,  William H. Cagney ,  Gordon Kosovan ,  Elaine Hughes ,  Maria Ficchi

IPC: A61B17/06 ,  A61J1/16 ,  B65D25/20 ,  B65D23/08 ,  B65D77/04 ,  A61J1/05

Abstract: A packaging system is provided for securely and irreversibly holding a sterile product. The packaging system includes a primary packaging holder and a secondary packaging holder. The secondary packaging holder has a body made up of a top having a receiving portion configured to receive the primary packaging holder, a base having a plurality of apertures and a first and second planar wall extending from opposing ends of the base in parallel to opposing ends of the top. The secondary packaging holder also has a first and second plate configured to secure opposing ends of an opening though the body. The first plate comprises a first securing feature, and the second plate comprises a second securing feature. The first and second securing features are capable of jointly securing and irreversibly holding the primary packaging holder in the secondary packaging holder.

公开(公告)号：US10258502B2

公开(公告)日：2019-04-16

申请号：US14843350

申请日：2015-09-02

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Mark C. Tsai ,  Brian M. Gatton, Jr. ,  Michael F. Keane ,  Isaac J. Khan ,  Brendan J. Oberkircher ,  Daniel W. Price

IPC: A61J1/06 ,  A61M5/20 ,  A61M5/315 ,  A61F9/00 ,  A61M5/31 ,  A61M39/10

Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.

公开(公告)号：US10226379B2

公开(公告)日：2019-03-12

申请号：US14619256

申请日：2015-02-11

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Brendan J. Oberkircher ,  Daniel W. Price ,  Michael F. Keane ,  Saeed Sokhanvar ,  Daniel J. Yasevac ,  Michel G. Bruehwiler ,  Leah R. Soffer ,  Isaac J. Khan ,  Benjamin L. Ko ,  Christopher D. Riemann ,  Nathan D. Grubbs

IPC: A61F9/00 ,  A61M5/158

Abstract: An apparatus for delivering therapeutic agent to an eye includes a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.

公开(公告)号：US10646374B2

公开(公告)日：2020-05-12

申请号：US15609386

申请日：2017-05-31

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Daniel W. Price ,  Brendan J. Oberkircher ,  Daniel J. Prenger ,  Geoffrey King ,  Thomas E. Meyer ,  Benjamin L. Ko

IPC: A61F9/007 ,  A61F9/00 ,  A61B17/34 ,  A61M5/20 ,  A61M5/24

Abstract: An apparatus includes an injector, a first fluid conduit, a second fluid line, and a control module. The injector includes a body, a flexible cannula, a flexible needle, and a sensor. The needle is configured to translate relative to the cannula. The sensor is operable to detect a position of the needle relative to the cannula. The first and second fluid lines are coupled with the needle. The control module is in communication with the sensor, with the first fluid conduit, and with the second fluid conduit. The control module is configured to provide delivery of a first fluid through the first conduit to the needle based on a signal from the sensor. The control module is further configured to provide delivery of a second fluid through the second conduit to the needle.

公开(公告)号：US11076984B2

公开(公告)日：2021-08-03

申请号：US15911315

申请日：2018-03-05

Applicant: Orbit Biomedical Limited

Inventor： Daniel W. Price ,  Brendan J. Oberkircher ,  Daniel J. Prenger ,  Geoffrey King ,  Isaac J. Khan ,  Michael F. Keane ,  Benjamin L. Ko

IPC: A61F9/00 ,  A61F9/007 ,  A61M5/158

Abstract: A method includes inserting a flexible cannula between a sclera and a choroid of an eye. The needle is advanced from a distal end of the flexible cannula, such that the needle pierces the choroid to access a subretinal space of the eye. The needle is used to aspirate fluid from the subretinal space. The fluid may be present from a retinal detachment, a macular hemorrhage, or other condition present before the procedure begins. The method may further include injecting the fluid in the subretinal space via the needle, in which case the fluid may be a balanced salt solution or other bleb fluid. The method may further include injecting a therapeutic agent into the subretinal space after aspirating the bleb fluid. The volume of injected bleb fluid may be greater than the volume of injected therapeutic agent.

公开(公告)号：US11058576B2

公开(公告)日：2021-07-13

申请号：US16184221

申请日：2018-11-08

Applicant: Orbit Biomedical Limited

Inventor： Brendan J. Oberkircher ,  Daniel W. Price ,  Michael F. Keane ,  Saeed Sokhanvar ,  Daniel J. Yasevac ,  Michel G. Bruehwiler ,  Leah R. Soffer ,  Isaac J. Khan ,  Benjamin L. Ko ,  Christopher D. Riemann ,  Nathan D. Grubbs

IPC: A61F9/00 ,  A61M5/158

Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.

公开(公告)号：USD886598S1

公开(公告)日：2020-06-09

申请号：US29663852

申请日：2018-09-19

Applicant: ORBIT BIOMEDICAL LIMITED

Designer： Chaley J. Larson ,  Michael Cannamela ,  William H. Cagney ,  Gordon Kosovan ,  Elaine Hughes ,  Maria Ficchi ,  Kostadinka Lilova

公开(公告)号：US10322028B2

公开(公告)日：2019-06-18

申请号：US14842035

申请日：2015-09-01

Applicant: ORBIT BIOMEDICAL LIMITED

Inventor： Daniel W. Price ,  Brendan J. Oberkircher ,  Saeed Sokhanvar ,  Daniel J. Yasevac ,  Michel Bruehwiler ,  Leah R. Soffer ,  Gregory W. Johnson ,  William D. Dannaher ,  Stefan Troller ,  Urban Schnell ,  Jean Christophe Roulet ,  Alain Saurer ,  Michael F. Keane

IPC: A61F9/00 ,  A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  G02B3/00 ,  A61B90/00 ,  A61B90/20

Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, an actuation assembly, and a detection/visualization system. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis. The cannula may be inserted through a sclerotomy incision and advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer. The detection/visualization system is operable to detect or visualize penetration of the choroid of a patient's eye and provide feedback to the operator and/or automatic control of the apparatus based on penetration of the choroid.