A tire pressure monitoring sensor includes a housing, a pressure sensor core, a PCB with a processing circuit, a battery, a transmitting antenna and a metallic cover plate. The pressure sensor core includes a tube socket, a silicon piezoresistive element, a sensor shell, a seal, a ceramic body, a pressure sensing and transferring medium, an output terminal, a metallic sensing diaphragm and a protective shield. The metallic sensing diaphragm is subjected to a pressure, which is delivered to through said pressure sensing and transferring medium, and finally a pressure signal is output by said output terminal. The tire pressure monitoring sensor meets the requirements for application in an engineering vehicle or a special vehicle, and is suitable for use in an environment in the presence of liquid.