A drying agent cartridge is provided for detachable fastening to a compressed-air treatment installation of a vehicle. A device is also provided for the detachable fastening of a drying agent cartridge to a housing of a compressed-air treatment installation of a vehicle. The drying agent cartridge include a cartridge housing which contains a drying agent, having a cover, a carrier element, a thread, which is arranged on the carrier element, and a corresponding counterpart thread, of a compressed-air treatment installation. The drying agent cartridge furthermore includes a seal groove on the carrier element underside, a sealing element in the seal groove, and a fluidic connection between the seal groove and a pressurizable chamber within the drying agent cartridge, via which fluidic connection the sealing element can be acted on, when the drying agent cartridge is in an installed position, with a system pressure of the compressed-air treatment installation.