Invention Grant
- Patent Title: Substituted benzooxadiazole DNA-PK inhibitors
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Application No.: US15133378Application Date: 2016-04-20
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Publication No.: US09987284B2Publication Date: 2018-06-05
- Inventor: John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K31/4245
- IPC: A61K31/4245 ; C07D271/12 ; A61K31/5377 ; C07D513/04 ; A61K31/506 ; A61K31/5386 ; C07D241/40 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/12 ; C07D405/14 ; C07D413/12 ; C07D417/12 ; C07D471/04 ; C07D473/40 ; C07D475/00 ; C07D487/04 ; C07D491/048 ; C07D498/08 ; C07D241/42 ; C07D413/04 ; C07D241/44 ; C07D491/052 ; C07D401/12 ; C07D413/14 ; C07D491/056 ; C07D491/08
Abstract:
Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.
Public/Granted literature
- US20160340341A1 DNA-PK INHIBITORS Public/Granted day:2016-11-24
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