A multi-band RF multiplexer for routing transmit and receive signals in a radio RF front end. According to one aspect, the disclosure provides a multiplexer for routing transmit signals to an antenna and routing receive signals to a receiver. The multiplexer provides a first hybrid coupler having a first frequency response and a second hybrid coupler having a second frequency response. The second hybrid coupler is coupled to the first hybrid coupler by a plurality of splitters. The second frequency response complements the first frequency response to increase cancellation of two signals arriving at an output port of the second hybrid coupler from two different paths through the first and second hybrid couplers.