Invention Grant
- Patent Title: Method for the selection of antibodies against BCMA
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Application No.: US14764967Application Date: 2014-02-05
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Publication No.: US09963513B2Publication Date: 2018-05-08
- Inventor: Minh Diem Vu , Klaus Strein , Ekkehard Moessner , Ralf Hosse , Oliver Ast , Anne Freimoser-Grundschober , Marina Bacac , Tanja Fauti , Christian Klein , Pablo Umana , Samuel Moser
- Applicant: ENGMAB AG
- Applicant Address: CH Boudry
- Assignee: ENGMAB SÀRL
- Current Assignee: ENGMAB SÀRL
- Current Assignee Address: CH Boudry
- Agency: Eckert Seamans Cherin & Mellott, LLC
- Priority: EP13000570 20130205; EP13000571 20130205
- International Application: PCT/EP2014/052189 WO 20140205
- International Announcement: WO2014/122143 WO 20140814
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/30 ; G01N33/68 ; C07K14/705 ; A61K39/00
Abstract:
An antibody specifically binding to human BCMA, characterized in that the binding of said antibody is not reduced by APRIL and not reduced by BAFF, said antibody does not alter APRIL-dependent NF-κB activation, BAFF-dependent NF-κB activation, and does not alter NF-κB activation without BAFF and APRIL is useful as a therapeutic agent.
Public/Granted literature
- US20150368351A1 METHOD FOR THE SELECTION OF ANTIBODIES AGAINST BCMA Public/Granted day:2015-12-24
Information query
