As disclosed herein a method, executed by a computer, for enabling multi-tiered software stack diagnostic collection includes initiating, on a first tier of a multi-tiered software stack, a targeted diagnostics collection corresponding to a symptom of a failure, determining a symptom to a reason code mapping corresponding to the symptom in a product of a subsequent tier, and issuing a command to the product of the subsequent tier to initiate targeted diagnostics collection corresponding to the reason code. Problems or failures in a multi-tiered software stack environment may require analyses of programs or products corresponding to each tier of a multi-tiered software stack. The method described herein enables simultaneous collection of diagnostics for programs or products corresponding to each tier of a multi-tiered software stack. A computer system, and a computer program product corresponding to the method are also disclosed herein.