An inbred corn line, designated XHE21, the plants and seeds of the inbred corn line XHE21, methods for producing a corn plant, either inbred or hybrid, produced by crossing the inbred corn line XHE21 with itself or with another corn plant, and hybrid corn seeds and plants produced by crossing the inbred line XHE21 with another corn line or plant and to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic corn plants produced by that method. This invention also relates to inbred corn lines derived from inbred corn line XHE21, to methods for producing other inbred corn lines derived from inbred corn line XHE21 and to the inbred corn lines derived by the use of those methods.