Invention Grant
- Patent Title: Identification of CD8+ T cells that are CD161hi and/or IL18Rαhi and have rapid drug efflux capacity
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Application No.: US14810286Application Date: 2015-07-27
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Publication No.: US09931384B2Publication Date: 2018-04-03
- Inventor: Cameron J. Turtle , Stanley R. Riddell
- Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
- Applicant Address: US WA Seattle
- Assignee: Fred Hutchinson Cancer Research Center
- Current Assignee: Fred Hutchinson Cancer Research Center
- Current Assignee Address: US WA Seattle
- Agency: Seed IP Law Group LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C12N5/0783 ; G01N33/50
Abstract:
This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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