In one aspect, a method for tuning input parameters to a synthesis program is provided which includes the steps of: (a) selecting a subset of parameter settings for the synthesis program based on a tuning optimization cost function; (b) individually running synthesis jobs in parallel for each of the parameter settings in the subset; (c) analyzing results from a current iteration and prior iterations, if any, using the cost function; (d) using the results from the current iteration and the prior iterations, if any, to create combinations of the parameter settings; (e) running synthesis jobs in parallel for the combinations of the parameter settings in a next iteration; and (f) repeating the steps (c)-(e) for one or more additional iterations or until an exit criteria has been met.