Invention Grant
- Patent Title: Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
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Application No.: US14418570Application Date: 2013-08-01
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Publication No.: US09908853B2Publication Date: 2018-03-06
- Inventor: Lakshmi Kotra , Mario Moscarello
- Applicant: University Health Network , The Hospital for Sick Children
- Applicant Address: CA Toronto CA Toronto
- Assignee: THE HOSPITAL FOR SICK CHILDREN,UNIVERSITY HEALTH NETWORK
- Current Assignee: THE HOSPITAL FOR SICK CHILDREN,UNIVERSITY HEALTH NETWORK
- Current Assignee Address: CA Toronto CA Toronto
- Agency: Bereskin & Parr LLP/S.E.N.C.R.L., S.R.L.
- Agent Patricia Folkins
- International Application: PCT/CA2013/050597 WO 20130801
- International Announcement: WO2014/019092 WO 20140206
- Main IPC: C07D233/74
- IPC: C07D233/74 ; C07D233/76 ; C07D233/78 ; C07D403/06
Abstract:
The present application relates to imidazolidinecliones, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes. In particular, the present application includes compounds of Formula I, and compositions and uses thereof: (I).
Public/Granted literature
- US20150252006A1 INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF Public/Granted day:2015-09-10
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