Invention Grant
- Patent Title: Aryl ethers and uses thereof
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Application No.: US14905776Application Date: 2014-09-05
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Publication No.: US09908845B2Publication Date: 2018-03-06
- Inventor: Darryl David Dixon , Jonas Grina , John A. Josey , James P. Rizzi , Stephen T. Schlachter , Eli M. Wallace , Bin Wang , Paul Wehn , Rui Xu , Hanbiao Yang
- Applicant: Peloton Therapeutics, Inc.
- Applicant Address: US TX Dallas
- Assignee: PELOTON THERAPEUTICS, INC.
- Current Assignee: PELOTON THERAPEUTICS, INC.
- Current Assignee Address: US TX Dallas
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2014/054375 WO 20140905
- International Announcement: WO2015/035223 WO 20150312
- Main IPC: C07C317/22
- IPC: C07C317/22 ; C07C43/225 ; C07C43/23 ; A61K31/09 ; A61K31/10 ; C07C311/29 ; C07C43/285 ; C07C43/205 ; C07C43/263 ; C07C255/54 ; C07C255/56 ; C07C205/22 ; C07C313/06 ; C07C317/24 ; C07C317/32 ; C07C317/34 ; C07C317/36 ; C07C317/40 ; C07C317/42 ; C07C317/44 ; C07C317/46 ; C07C317/48 ; C07C323/22 ; C07C381/10 ; C07D213/89 ; C07D231/56 ; C07D213/65 ; C07D213/85
Abstract:
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
Public/Granted literature
- US20160251307A1 ARYL ETHERS AND USES THEREOF Public/Granted day:2016-09-01
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