Methods for overcoming latency and throughput degradation ensuing from packet fragmentation performed at a source node are disclosed. Some embodiments of the disclosed methods may be applicable to networks in which performance enhancement methods are used, including but not limited to TCP acceleration methods. In some embodiments, the disclosed methods may include determining an MTU for a session based on one or more fragmentation policies. Also disclosed is a satellite communication system that may be configured to resolve one or more detrimental effects on TCP spoofing resulting from the MTU discovery mechanism of IPv6.