A method for annotation of skin images includes receiving a plurality of dermatoscopic images. Each of the dermatoscopic includes a region of lesion skin and a region of normal skin. A first convolutional neural network is trained according to an interior of the region of lesion skin using each of the plurality of dermatoscopic images. A second convolutional neural network is trained according to a boundary between the region of lesion skin and the region of normal skin. An additional dermatoscopic image is acquired. The first and second convolutional neural networks are used to identify a region of lesion skin within the acquired additional dermatoscopic image.