A method of detecting a possible collision in a medical procedure that involves a medical system, includes: obtaining an image of a patient that is supported on a patient support; determining a first model using a processing unit based at least in part on the image, at least a part of the first model representing a surface of the patient; determining a second model using the processing unit, the second model representing a first component of the medical system; virtually moving the first model, the second model, or both, using a collision prediction mechanism to simulate a movement of the first component of the medical system to determine whether there is a possible collision between the first component and the patient; and generating an output to indicate the possible collision or an absence of the possible collision.