Invention Grant
- Patent Title: KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammals
-
Application No.: US14765251Application Date: 2014-01-31
-
Publication No.: US09884891B2Publication Date: 2018-02-06
- Inventor: Massimiliano Beltramo , Vincent Aucagne , Alain Caraty , Agnes Delmas , Mathieu Galibert
- Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Applicant Address: FR Paris FR Paris
- Assignee: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: FR Paris FR Paris
- Agency: Young & Thompson
- Priority: FR1350858 20130131
- International Application: PCT/EP2014/051886 WO 20140131
- International Announcement: WO2014/118318 WO 20140807
- Main IPC: A61K38/14
- IPC: A61K38/14 ; A61K38/00 ; A61K38/04 ; A61K38/06 ; A61K38/07 ; A61K38/08 ; C07K5/00 ; C07K7/00 ; C07K9/00 ; C07K16/00 ; C07K17/00 ; C07K7/06 ; C07K5/02 ; C07K7/02 ; C07K14/575

Abstract:
A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -XaaΨ[Tz]Xaa2-Xaa3-Xaa4-NH2 (SEQ ID NO: 3), where Ψ[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic α-aminoacyl analog residue, Xaa3 is Arg, Arg(Me) or a positively charged α-aminoacyl analog residue, and Xaa4 is Tyr, Phe, Trp or an α-aminoacyl analog residue such as aryl alanine; or an analog of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.
Public/Granted literature
- US20150361138A1 KISS1R RECEPTOR AGONIST COMPOUNDS AND USE THEREOF FOR INDUCING OVULATION IN MAMMALS Public/Granted day:2015-12-17
Information query
IPC分类: