Invention Grant
- Patent Title: Substituted cinnolines as inhibitors of LRRK2 kinase activity
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Application No.: US14122199Application Date: 2012-05-21
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Publication No.: US09884828B2Publication Date: 2018-02-06
- Inventor: Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
- Applicant: Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
- Applicant Address: US WY Jackson Hole
- Assignee: Imago Pharmaceuticals, Inc.
- Current Assignee: Imago Pharmaceuticals, Inc.
- Current Assignee Address: US WY Jackson Hole
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2012/038871 WO 20120521
- International Announcement: WO2012/162254 WO 20121129
- Main IPC: A61K31/502
- IPC: A61K31/502 ; C07D237/28 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/10 ; C07D405/04 ; C07D405/10 ; C07D405/12 ; C07D417/04 ; C07D413/10
Abstract:
The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
Public/Granted literature
- US20150284337A1 INHIBITORS OF LRRK2 KINASE ACTIVITY Public/Granted day:2015-10-08
Information query
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