Invention Grant
- Patent Title: Cyclic vinylogous amides as bromodomain inhibitors
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Application No.: US14914672Application Date: 2014-08-29
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Publication No.: US09884806B2Publication Date: 2018-02-06
- Inventor: Ming-Ming Zhou , Michael Ohlmeyer , Adam Vincek , Nilesh Zaware
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Agency: Heslin, Rothenberg, Farley & Mesiti, P.C.
- International Application: PCT/US2014/053527 WO 20140829
- International Announcement: WO2015/031824 WO 20150305
- Main IPC: A61K31/136
- IPC: A61K31/136 ; A61K31/166 ; A61K31/18 ; A61K31/195 ; A61K31/196 ; A61K31/245 ; A61K31/277 ; A61K31/404 ; A61K31/4184 ; A61K31/4192 ; A61K31/44 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/4468 ; A61K31/47 ; A61K31/4965 ; A61K31/498 ; A61K31/517 ; A61K31/5375 ; A61K45/06 ; C07D209/08 ; C07D209/40 ; C07D211/58 ; C07D213/74 ; C07D213/75 ; C07D213/76 ; C07D215/06 ; C07D215/38 ; C07D217/02 ; C07D239/74 ; C07D241/20 ; C07D241/42 ; C07D249/04 ; C07D249/06 ; C07D295/16 ; C07D295/21 ; C07C225/20 ; C07C229/48 ; C07C229/56 ; C07C229/60 ; C07C229/68 ; C07C237/30 ; C07C237/40 ; C07C255/58 ; C07C311/38 ; C07D235/26
Abstract:
Cyclic vinylogous amides of Formula I are disclosed The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
Public/Granted literature
- US20160200666A1 CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS Public/Granted day:2016-07-14
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