Invention Grant
- Patent Title: Substituted aromatic compounds for the treatment pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis
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Application No.: US14775882Application Date: 2014-03-14
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Publication No.: US09884802B2Publication Date: 2018-02-06
- Inventor: Lyne Gagnon , Pierre Laurin , Brigitte Grouix , Lilianne Geerts , François Sarra-Bournet , Martin Leduc , Shaun Abbott , Boulos Zacharie , Jean-François Bienvenu , Valérie Perron
- Applicant: PROMETIC BIOSCIENCES INC.
- Applicant Address: GB Cambridge
- Assignee: PROMETIC PHARMA SMT LIMITED
- Current Assignee: PROMETIC PHARMA SMT LIMITED
- Current Assignee Address: GB Cambridge
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/CA2014/000237 WO 20140314
- International Announcement: WO2014/138907 WO 20140918
- Main IPC: C07C57/30
- IPC: C07C57/30 ; A61K31/192 ; C07C59/52 ; C07C57/58 ; C07C57/42 ; C07C57/60 ; C07C59/84 ; A61K31/4418 ; A61K45/06

Abstract:
The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2—OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH.
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