A system and method for using multi-axis deposition tool heads on a machine such as a three dimensional fabrication device like a 3D Printer, for novel automation and additive manufacturing techniques which offer increased output product quality and fabrication speed by introducing a novel cartridge and deposition systems and techniques. The system allows a plurality of materials, some reacted or mixed by the device, to be extruded through a deposition head, which may adaptively (and automatically) change shape and lumen size to accommodate different path widths and shapes. The cartridge system may employ pellets which may be comprised of a plurality of materials and/or colors.