The invention is a method of managing communication between a host device and a secure element comprising two virtual profiles. The method comprises the steps of: running simultaneously both virtual profiles in the secure element, generating an incoming data from the host device by multiplexing a first command targeting one virtual profile and another command targeting the other virtual profile and sending the incoming data to the secure element, demultiplexing both commands at the secure element side and sending each command to the targeted virtual profile, getting response messages generated by both virtual profiles by executing said commands, generating an outgoing data by multiplexing the response messages and sending this outgoing data to the host device, and demultiplexing the response messages at the host device side.