An isolation system is disclosed that contains: a lower wet connect portion, a central production tubing, an isolation device associated with the central production tubing, and at least one communication line, wherein the at least one communication line is associated with the lower wet connect portion and is disposed through an inside diameter of the isolation device. Further, a method for isolating a lower completion is disclosed that includes: conveying an isolation assembly to the lower completion, the isolation assembly including: a lower wet isolation device; and routing the at least one communication line through an inside diameter of the isolation device. Further a completion system is disclosed that contains a lower completion system and an isolation system associated with the lower completion system.