- Patent Title: Processes for making compounds useful as inhibitors of ATR kinase
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Application No.: US14678489Application Date: 2015-04-03
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Publication No.: US09862709B2Publication Date: 2018-01-09
- Inventor: Jean-Damien Charrier , John Studley , Francoise Yvonne Theodora Marie Pierard , Steven John Durrant , Benjamin Joseph Littler , Robert Michael Hughes , David Andrew Siesel , Paul Angell , Armando Urbina , Yi Shi
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Dechert LLP
- Agent Andrea L. C. Reid
- Main IPC: C07D413/04
- IPC: C07D413/04 ; C07D413/14 ; C07C251/48 ; C07D241/20
Abstract:
The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I or II: wherein the variables are as defined herein.
Public/Granted literature
- US20150274710A1 PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Public/Granted day:2015-10-01
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