Invention Grant
- Patent Title: 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
-
Application No.: US15140350Application Date: 2016-04-27
-
Publication No.: US09751858B2Publication Date: 2017-09-05
- Inventor: Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Klaus Wirth
- Applicant: SANOFI
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP11305971 20110726
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D277/56 ; A61K31/426 ; C07D233/90 ; A61K31/4164 ; C07D261/18 ; A61K31/42 ; C07D263/34 ; A61K31/421 ; C07D231/14 ; A61K31/415 ; C07D271/06 ; A61K31/4245 ; C07D249/10 ; A61K31/4196 ; C07D307/68 ; A61K31/341 ; A61K31/454 ; A61K45/06 ; C07D271/10 ; C07D277/32 ; C07D285/08

Abstract:
The present invention relates to compounds of the formula I, wherein Ht, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20160237060A1 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2016-08-18
Information query