Invention Grant
- Patent Title: Molecules and compositions that inhibit gram negative bacteria and their uses
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Application No.: US15023279Application Date: 2014-09-19
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Publication No.: US09751851B2Publication Date: 2017-09-05
- Inventor: Bonnie L. Bassler , Martin F. Semmelhack , Knut Drescher , Albert Siryaporn , Laura C. Conrad-Miller , Colleen T. O'Loughlin
- Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY , Bonnie L. Bassler , Martin F. Semmelhack , Knut Drescher , Albert Siryaporn , Laura C. Miller , Colleen T. O'Loughlin
- Applicant Address: US NJ Princeton
- Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
- Current Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
- Current Assignee Address: US NJ Princeton
- Agency: Meagher Emanuel Laks Goldberg & Liao, LLP
- International Application: PCT/US2014/056497 WO 20140919
- International Announcement: WO2015/042363 WO 20150326
- Main IPC: C07D333/32
- IPC: C07D333/32 ; A61K45/06 ; C07D213/75 ; C07D239/42 ; C07D239/47 ; C07D307/33
Abstract:
Antivirulence strategies to combat Pseudomonas aeruginosa, are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.
Public/Granted literature
- US20160368892A1 MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES Public/Granted day:2016-12-22
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