- Patent Title: Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders
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Application No.: US14196483Application Date: 2014-03-04
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Publication No.: US09724435B2Publication Date: 2017-08-08
- Inventor: Christopher R. McCurdy , Christophe Mesangeau , Frederick T. Chin , Michelle L. James , Bin Shen , Sanjiv Gambhir , Sandip Biswal , Deepak Behera
- Applicant: The University of Mississippi , The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US MS University US CA Palo Alto
- Assignee: THE UNIVERSITY OF MISSISSIPPI,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee: THE UNIVERSITY OF MISSISSIPPI,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee Address: US MS University US CA Palo Alto
- Agency: Hershkovitz & Associates, PLLC
- Agent Abraham Hershkovitz; Eugene C. Rzucidlo
- Main IPC: A61K31/428
- IPC: A61K31/428 ; C07D209/48 ; C07D235/26 ; C07D263/58 ; C07D277/68 ; C07D403/06 ; C07D405/04 ; C07D413/06 ; C07D413/12 ; C07D417/06 ; C07D491/107 ; C07D491/20 ; A61K51/04 ; C07D265/36 ; C07D209/08 ; C07D209/10 ; C07D277/70 ; C07D279/16 ; C07D295/13 ; C07D277/74
Abstract:
A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III′, or IV′:
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