A system for exchanging at least one end tool includes at least one tool exchange device for retaining each of the at least one end tool and at least one operating instrument engageable with each of the at least one end tool. The tool exchange device includes a tool retaining mechanism having an opening and a plurality of engagement features to enable mutually exclusive engagement and disengagement of the tool retaining mechanism with each of the at least one tool. Each of the at least one tool is receivable in the opening and has a biasing member engageable with the plurality of engagement features for at least one of biasing to an engaged position and a disengaged position.