An anomaly detection system is provided in connection with a transport service. The anomaly detection system can construct routine route profiles for individual users of the transport service using historical route data. The anomaly detection system can monitor a current route traveled by a user. The anomaly detection system can further identify a matching routine route profile of the respective user. The anomaly detection system can utilize the matching routine route profile to identify a probable anomaly in the current route. In response to detecting the probable anomaly, the anomaly detection system can enable a safety protocol to perform a number of actions.